Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2WH0

Recognition of an intrachain tandem 14-3-3 binding site within protein kinase C epsilon

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0001525	biological_process	angiogenesis
A	0003016	biological_process	respiratory system process
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0006468	biological_process	protein phosphorylation
A	0006605	biological_process	protein targeting
A	0007165	biological_process	signal transduction
A	0008039	biological_process	synaptic target recognition
A	0008104	biological_process	protein localization
A	0019901	molecular_function	protein kinase binding
A	0019904	molecular_function	protein domain specific binding
A	0030324	biological_process	lung development
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0031647	biological_process	regulation of protein stability
A	0031982	cellular_component	vesicle
A	0035148	biological_process	tube formation
A	0042149	biological_process	cellular response to glucose starvation
A	0042470	cellular_component	melanosome
A	0042802	molecular_function	identical protein binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0043067	biological_process	regulation of programmed cell death
A	0044325	molecular_function	transmembrane transporter binding
A	0045296	molecular_function	cadherin binding
A	0045824	biological_process	negative regulation of innate immune response
A	0050815	molecular_function	phosphoserine residue binding
A	0051683	biological_process	establishment of Golgi localization
A	0070062	cellular_component	extracellular exosome
A	0070371	biological_process	ERK1 and ERK2 cascade
A	0070372	biological_process	regulation of ERK1 and ERK2 cascade
A	0072562	cellular_component	blood microparticle
A	0090128	biological_process	regulation of synapse maturation
A	0090168	biological_process	Golgi reassembly
A	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
A	0098978	cellular_component	glutamatergic synapse
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0140311	molecular_function	protein sequestering activity
A	1900181	biological_process	negative regulation of protein localization to nucleus
A	1904262	biological_process	negative regulation of TORC1 signaling
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0001525	biological_process	angiogenesis
B	0003016	biological_process	respiratory system process
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005925	cellular_component	focal adhesion
B	0006468	biological_process	protein phosphorylation
B	0006605	biological_process	protein targeting
B	0007165	biological_process	signal transduction
B	0008039	biological_process	synaptic target recognition
B	0008104	biological_process	protein localization
B	0019901	molecular_function	protein kinase binding
B	0019904	molecular_function	protein domain specific binding
B	0030324	biological_process	lung development
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0031647	biological_process	regulation of protein stability
B	0031982	cellular_component	vesicle
B	0035148	biological_process	tube formation
B	0042149	biological_process	cellular response to glucose starvation
B	0042470	cellular_component	melanosome
B	0042802	molecular_function	identical protein binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0043067	biological_process	regulation of programmed cell death
B	0044325	molecular_function	transmembrane transporter binding
B	0045296	molecular_function	cadherin binding
B	0045824	biological_process	negative regulation of innate immune response
B	0050815	molecular_function	phosphoserine residue binding
B	0051683	biological_process	establishment of Golgi localization
B	0070062	cellular_component	extracellular exosome
B	0070371	biological_process	ERK1 and ERK2 cascade
B	0070372	biological_process	regulation of ERK1 and ERK2 cascade
B	0072562	cellular_component	blood microparticle
B	0090128	biological_process	regulation of synapse maturation
B	0090168	biological_process	Golgi reassembly
B	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
B	0098978	cellular_component	glutamatergic synapse
B	0140297	molecular_function	DNA-binding transcription factor binding
B	0140311	molecular_function	protein sequestering activity
B	1900181	biological_process	negative regulation of protein localization to nucleus
B	1904262	biological_process	negative regulation of TORC1 signaling
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0001525	biological_process	angiogenesis
C	0003016	biological_process	respiratory system process
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005925	cellular_component	focal adhesion
C	0006468	biological_process	protein phosphorylation
C	0006605	biological_process	protein targeting
C	0007165	biological_process	signal transduction
C	0008039	biological_process	synaptic target recognition
C	0008104	biological_process	protein localization
C	0019901	molecular_function	protein kinase binding
C	0019904	molecular_function	protein domain specific binding
C	0030324	biological_process	lung development
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0031647	biological_process	regulation of protein stability
C	0031982	cellular_component	vesicle
C	0035148	biological_process	tube formation
C	0042149	biological_process	cellular response to glucose starvation
C	0042470	cellular_component	melanosome
C	0042802	molecular_function	identical protein binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0043067	biological_process	regulation of programmed cell death
C	0044325	molecular_function	transmembrane transporter binding
C	0045296	molecular_function	cadherin binding
C	0045824	biological_process	negative regulation of innate immune response
C	0050815	molecular_function	phosphoserine residue binding
C	0051683	biological_process	establishment of Golgi localization
C	0070062	cellular_component	extracellular exosome
C	0070371	biological_process	ERK1 and ERK2 cascade
C	0070372	biological_process	regulation of ERK1 and ERK2 cascade
C	0072562	cellular_component	blood microparticle
C	0090128	biological_process	regulation of synapse maturation
C	0090168	biological_process	Golgi reassembly
C	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
C	0098978	cellular_component	glutamatergic synapse
C	0140297	molecular_function	DNA-binding transcription factor binding
C	0140311	molecular_function	protein sequestering activity
C	1900181	biological_process	negative regulation of protein localization to nucleus
C	1904262	biological_process	negative regulation of TORC1 signaling
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0001525	biological_process	angiogenesis
D	0003016	biological_process	respiratory system process
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005925	cellular_component	focal adhesion
D	0006468	biological_process	protein phosphorylation
D	0006605	biological_process	protein targeting
D	0007165	biological_process	signal transduction
D	0008039	biological_process	synaptic target recognition
D	0008104	biological_process	protein localization
D	0019901	molecular_function	protein kinase binding
D	0019904	molecular_function	protein domain specific binding
D	0030324	biological_process	lung development
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0031647	biological_process	regulation of protein stability
D	0031982	cellular_component	vesicle
D	0035148	biological_process	tube formation
D	0042149	biological_process	cellular response to glucose starvation
D	0042470	cellular_component	melanosome
D	0042802	molecular_function	identical protein binding
D	0043066	biological_process	negative regulation of apoptotic process
D	0043067	biological_process	regulation of programmed cell death
D	0044325	molecular_function	transmembrane transporter binding
D	0045296	molecular_function	cadherin binding
D	0045824	biological_process	negative regulation of innate immune response
D	0050815	molecular_function	phosphoserine residue binding
D	0051683	biological_process	establishment of Golgi localization
D	0070062	cellular_component	extracellular exosome
D	0070371	biological_process	ERK1 and ERK2 cascade
D	0070372	biological_process	regulation of ERK1 and ERK2 cascade
D	0072562	cellular_component	blood microparticle
D	0090128	biological_process	regulation of synapse maturation
D	0090168	biological_process	Golgi reassembly
D	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
D	0098978	cellular_component	glutamatergic synapse
D	0140297	molecular_function	DNA-binding transcription factor binding
D	0140311	molecular_function	protein sequestering activity
D	1900181	biological_process	negative regulation of protein localization to nucleus
D	1904262	biological_process	negative regulation of TORC1 signaling

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA D 1230

Chain	Residue
D	GLU31
D	ASP96

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE B 1229

Chain	Residue
B	PHE153
B	SER156
B	PRO162
B	ARG167
B	ALA195
B	GLU198

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG41-VAL51

site_id	PS00797
Number of Residues	20
Details	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS

Chain	Residue	Details
A	TYR211-SER230

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine; by GSK3-beta => ECO:0000305\|PubMed:19662078

Chain	Residue	Details
Q	SEP346
R	SEP346
B	ARG56
B	ARG127
C	ARG56
C	ARG127
D	ARG56
D	ARG127

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P16054

Chain	Residue	Details
Q	THR349
R	THR349
C	MET1
D	MET1

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by MAPK11 and MAPK14 => ECO:0000250\|UniProtKB:P16054, ECO:0000305

Chain	Residue	Details
Q	SER350
R	SER350
B	LYS3
B	LYS68
C	LYS3
C	LYS68
D	LYS3
D	LYS68

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000305\|PubMed:19662078, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
Q	SEP368
R	SEP368
C	SER58
D	SER58

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by MAPK8 => ECO:0000269\|PubMed:15071501, ECO:0000269\|PubMed:15696159

Chain	Residue	Details
A	SER184
B	SER184
C	SER184
D	SER184

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19690332, ECO:0007744\|PubMed:20068231

Chain	Residue	Details
A	SER207
B	SER207
C	SER207
D	SER207

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P63102

Chain	Residue	Details
A	SER210
B	SER210
C	SER210
D	SER210

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by CK1 => ECO:0000269\|PubMed:31024343, ECO:0000269\|PubMed:9360956, ECO:0007744\|PubMed:20068231

Chain	Residue	Details
A	THR232
B	THR232
C	THR232
D	THR232

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)