2WGW
Crystal structure of the OXA-10 V117T mutant at pH 8.0
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008658 | molecular_function | penicillin binding |
| A | 0008800 | molecular_function | beta-lactamase activity |
| A | 0017001 | biological_process | antibiotic catabolic process |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0071555 | biological_process | cell wall organization |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008658 | molecular_function | penicillin binding |
| B | 0008800 | molecular_function | beta-lactamase activity |
| B | 0017001 | biological_process | antibiotic catabolic process |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0071555 | biological_process | cell wall organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1266 |
| Chain | Residue |
| B | SER67 |
| B | HOH2237 |
| B | SER115 |
| B | LYS205 |
| B | THR206 |
| B | GLY207 |
| B | PHE208 |
| B | ARG250 |
| B | HOH2186 |
| B | HOH2236 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1265 |
| Chain | Residue |
| A | SER67 |
| A | SER115 |
| A | LYS205 |
| A | THR206 |
| A | GLY207 |
| A | PHE208 |
| A | ARG250 |
| A | HOH2208 |
| A | HOH2263 |
| A | HOH2264 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1266 |
| Chain | Residue |
| A | LYS134 |
| A | LYS138 |
| A | LYS152 |
| A | HOH2155 |
| A | HOH2265 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1267 |
| Chain | Residue |
| B | ARG131 |
| B | LYS134 |
| B | TYR135 |
| B | HOH2238 |
| B | HOH2239 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1267 |
| Chain | Residue |
| A | LYS138 |
| A | PHE139 |
| A | SER140 |
| A | GLU168 |
| A | SER172 |
| A | HOH2266 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1268 |
| Chain | Residue |
| A | ARG125 |
| A | GLY128 |
| A | GLU129 |
| A | PHE208 |
| A | GLU244 |
| A | HOH2239 |
| A | HOH2267 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 1268 |
| Chain | Residue |
| B | LEU43 |
| B | SER50 |
| B | ALA52 |
| B | TYR233 |
| B | HOH2231 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 1269 |
| Chain | Residue |
| A | PRO198 |
| A | GLU199 |
| A | GLU227 |
| A | GLU229 |
| B | THR107 |
| B | ARG109 |
| B | GLY110 |
| B | HOH2240 |
| B | HOH2241 |
| B | HOH2242 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL B 1270 |
| Chain | Residue |
| A | THR107 |
| A | ARG109 |
| A | GLY110 |
| B | GLU199 |
| B | TYR200 |
| B | LEU201 |
| B | GLU227 |
| B | GLU229 |
| B | HOH2195 |
| B | HOH2243 |
| B | HOH2244 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1269 |
| Chain | Residue |
| A | TRP92 |
| A | GLY94 |
| A | PRO96 |
| A | ASN145 |
| A | HOH2268 |
| A | HOH2269 |
| A | HOH2270 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1270 |
| Chain | Residue |
| A | THR80 |
| A | GLY81 |
| A | ARG131 |
| A | HOH2070 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1271 |
| Chain | Residue |
| B | LYS138 |
| B | PHE139 |
| B | SER140 |
| B | GLU168 |
| B | SER172 |
| B | HOH2246 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1271 |
| Chain | Residue |
| A | MET99 |
| A | LYS100 |
| A | SER147 |
| A | GLY148 |
| A | GLY149 |
Functional Information from PROSITE/UniProt
| site_id | PS00337 |
| Number of Residues | 11 |
| Details | BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnAI |
| Chain | Residue | Details |
| B | PRO65-ILE75 | |
| A | PRO65-ILE75 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"11724923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WGI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"11188693","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11724923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E4D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K55","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2RL3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
