2WGE

Crystal structure of KasA of Mycobacterium tuberculosis with bound TLM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006633	biological_process	fatty acid biosynthetic process
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0019367	biological_process	fatty acid elongation, saturated fatty acid
A	0030497	biological_process	fatty acid elongation
A	0042802	molecular_function	identical protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1417

Chain	Residue
A	GLY92
A	GLN93
A	GLU96
A	HOH2089
A	HOH2278

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1418

Chain	Residue
A	ARG363
A	HOH2268
A	HOH2269
A	HOH2270
A	ALA18
A	VAL19
A	GLU30
A	SER97

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1419

Chain	Residue
A	PHE275
A	ALA282
A	ASP283
A	HOH2271
A	HOH2272
A	HOH2273

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1420

Chain	Residue
A	TRP95
A	PRO101
A	VAL103
A	LEU158
A	HOH2127
A	HOH2274
A	HOH2275

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1421

Chain	Residue
A	GLU199
A	GLY200
A	PRO201
A	ILE202
A	GLU203
A	PRO206
A	PHE239
A	ILE347
A	HOH2276

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1422

Chain	Residue
A	PRO27
A	ASP28
A	GLN93
A	HOH2277
A	HOH2278
A	HOH2279

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IPA A 1423

Chain	Residue
A	MET213
A	VAL278
A	HOH2280

---

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TLM A 1424

Chain	Residue
A	CYS171
A	PHE237
A	VAL278
A	ALA279
A	PRO280
A	HIS311
A	THR313
A	HIS345
A	PHE402
A	GLY403
A	PHE404
A	GLY406
A	HOH2265

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1425

Chain	Residue
A	ASP283
A	VAL285
A	HOH2104
A	HOH2105
A	HOH2272
A	HOH2281

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 1426

Chain	Residue
A	ASN309
A	ALA310
A	GLU354
A	ASN399
A	ASN400

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348, ECO:0000305|PubMed:19604480, ECO:0000305|PubMed:24108128, ECO:0000305|PubMed:24479625

Chain	Residue	Details
A	CYS171

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348

Chain	Residue	Details
A	HIS311
A	HIS345

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305|PubMed:19604480, ECO:0000305|PubMed:24108128

Chain	Residue	Details
A	HIS311
A	HIS345

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	SITE: Interacts with the inhibitor thiolactomycin => ECO:0000269|PubMed:19604480, ECO:0000269|PubMed:24108128

Chain	Residue	Details
A	CYS171
A	HIS311
A	HIS345

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1kas

Chain	Residue	Details
A	HIS345
A	HIS311
A	PHE404
A	CYS171

---

site_id	CSA2
Number of Residues	6
Details	Annotated By Reference To The Literature 1kas

Chain	Residue	Details
A	HIS345
A	HIS311
A	PHE404
A	LYS340
A	CYS171
A	PHE402

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