2WG4
Crystal structure of the complex between human hedgehog-interacting protein HIP and sonic hedgehog without calcium
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1190 |
| Chain | Residue |
| A | HIS141 |
| A | ASP148 |
| A | HIS183 |
| B | ASP383 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 1667 |
| Chain | Residue |
| B | ARG410 |
| B | SER411 |
| B | ASN412 |
| B | ASP473 |
| B | TYR474 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA B 1668 |
| Chain | Residue |
| B | PRO441 |
| B | ASP443 |
| B | ILE446 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA B 1669 |
| Chain | Residue |
| B | SER286 |
| B | LEU287 |
| B | LEU357 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA B 1670 |
| Chain | Residue |
| B | HIS269 |
| B | VAL272 |
| B | GLN273 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18794898","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19561611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20519495","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18794898","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19561611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20519495","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7477329","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 27 |
| Details | Domain: {"description":"EGF-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Region: {"description":"Interaction with SHH zinc binding site"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19561611","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1c9u |
| Chain | Residue | Details |
| B | HIS352 | |
| B | ASP371 |
