2WFP

Crystal structure of mannose 6-phosphate isomerase (apo form) from Salmonella typhimurium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004476	molecular_function	mannose-6-phosphate isomerase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0008270	molecular_function	zinc ion binding
A	0009298	biological_process	GDP-mannose biosynthetic process
A	0016853	molecular_function	isomerase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1392

Chain	Residue
A	ARG353
A	LYS354
A	ASP355
A	PRO375
A	ASN377
A	HOH2359

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1393

Chain	Residue
A	THR278
A	EDO1403
A	HOH2262
A	HOH2360
A	LYS195
A	ASP227
A	SER228

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1394

Chain	Residue
A	SER95
A	GLN97
A	HOH2106

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1395

Chain	Residue
A	ILE96
A	PHE184
A	SER228
A	GLY229
A	PHE231
A	SER232
A	ALA275

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1396

Chain	Residue
A	ASN6
A	LYS307
A	SER308
A	GLY309
A	EDO1400
A	HOH2364

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1397

Chain	Residue
A	ALA185
A	ASN189
A	ILE284

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1398

Chain	Residue
A	ARG77
A	VAL155
A	LEU172
A	PRO175
A	EDO1405
A	HOH2361
A	HOH2362

---

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 1399

Chain	Residue
A	HOH2363

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1400

Chain	Residue
A	ASN6
A	GLY364
A	EDO1396
A	HOH2014
A	HOH2364

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1401

Chain	Residue
A	ALA310
A	GLU311
A	HIS326
A	SER334
A	HOH2315
A	HOH2365

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1402

Chain	Residue
A	ASN104
A	LYS111
A	TYR126
A	GLU286
A	ASN290
A	HOH2366

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1403

Chain	Residue
A	MET190
A	GLN191
A	LYS195
A	EDO1393
A	HOH2226
A	HOH2229
A	HOH2368

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1404

Chain	Residue
A	GLN97
A	HIS99
A	GLU134
A	LEU249
A	HIS255
A	GLU264

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1405

Chain	Residue
A	ASN76
A	EDO1398
A	HOH2093
A	HOH2368
A	HOH2369
A	HOH2370

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1406

Chain	Residue
A	ALA298
A	GLY299
A	GLU300
A	LEU301
A	LEU302

---

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1407

Chain	Residue
A	ALA40
A	PRO42
A	ARG59
A	GLU80
A	LEU81
A	ASN268
A	HOH2372

---

Functional Information from PROSITE/UniProt

site_id	PS00965
Number of Residues	9
Details	PMI_I_1 Phosphomannose isomerase type I signature 1. YkDpNHKPE

Chain	Residue	Details
A	TYR126-GLU134

---

site_id	PS00966
Number of Residues	26
Details	PMI_I_2 Phosphomannose isomerase type I signature 2. HAYLqGvaLEvMAnSDNvLRAGlTPK

Chain	Residue	Details
A	HIS255-LYS280

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1pmi

Chain	Residue	Details
A	GLN97
A	GLU264
A	ARG274

---