2WEU
Crystal structure of tryptophan 5-halogenase (PyrH) complex with substrate tryptophan
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0017000 | biological_process | antibiotic biosynthetic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0017000 | biological_process | antibiotic biosynthetic process |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0017000 | biological_process | antibiotic biosynthetic process |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004497 | molecular_function | monooxygenase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0017000 | biological_process | antibiotic biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE TRP A 1512 |
| Chain | Residue |
| A | PHE49 |
| A | GLY450 |
| A | TYR454 |
| A | HOH2114 |
| A | HOH2341 |
| A | SER50 |
| A | THR51 |
| A | HIS92 |
| A | PRO93 |
| A | PHE94 |
| A | GLN160 |
| A | GLN163 |
| A | GLU354 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TRP B 1512 |
| Chain | Residue |
| B | PHE49 |
| B | SER50 |
| B | THR51 |
| B | HIS92 |
| B | PRO93 |
| B | PHE94 |
| B | GLN160 |
| B | GLN163 |
| B | GLU354 |
| B | GLY450 |
| B | PHE451 |
| B | TYR454 |
| B | HOH2105 |
| B | HOH2112 |
| B | HOH2341 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TRP C 1512 |
| Chain | Residue |
| C | PHE49 |
| C | SER50 |
| C | THR51 |
| C | HIS92 |
| C | PRO93 |
| C | PHE94 |
| C | GLN160 |
| C | GLN163 |
| C | GLU354 |
| C | GLY450 |
| C | TYR454 |
| C | HOH2115 |
| C | HOH2332 |
| C | HOH2336 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TRP D 1512 |
| Chain | Residue |
| D | PHE49 |
| D | SER50 |
| D | THR51 |
| D | HIS92 |
| D | PRO93 |
| D | PHE94 |
| D | GLN160 |
| D | GLN163 |
| D | GLU354 |
| D | GLY450 |
| D | PHE451 |
| D | TYR454 |
| D | HOH2091 |
| D | HOH2095 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"P95480","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 37 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19501593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WET","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19501593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WET","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19501593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WEU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for activity","evidences":[{"source":"UniProtKB","id":"P95480","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
