2WEF

Human 3'(2'), 5'-bisphosphate nucleotidase 1 (BPNT1) in complex with AMP, PO4 and Magnesium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004441	molecular_function	inositol-1,4-bisphosphate 1-phosphatase activity
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0007399	biological_process	nervous system development
A	0008441	molecular_function	3'(2'),5'-bisphosphate nucleotidase activity
A	0016787	molecular_function	hydrolase activity
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 401

Chain	Residue
A	ASP117
A	ASP120
A	ASP247
A	MG402
A	PO4501
A	AMP601
A	HOH2206

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 402

Chain	Residue
A	LEU119
A	MG401
A	PO4501
A	HOH2038
A	GLU74
A	ASP117

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 403

Chain	Residue
A	GLU74
A	PO4501
A	HOH2033
A	HOH2035
A	HOH2064
A	HOH2249

---

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE PO4 A 501

Chain	Residue
A	ASP51
A	GLU74
A	ASP117
A	LEU119
A	ASP120
A	GLY121
A	THR122
A	MG401
A	MG402
A	MG403
A	AMP601
A	HOH2035
A	HOH2038
A	HOH2064
A	HOH2206
A	HOH2248
A	HOH2249

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE AMP A 601

Chain	Residue
A	ASP120
A	THR195
A	HIS198
A	GLY220
A	LYS224
A	PHE238
A	GLY242
A	CYS243
A	ASP247
A	MG401
A	PO4501
A	HOH2118
A	HOH2206
A	HOH2249
A	HOH2250
A	HOH2251

---

Functional Information from PROSITE/UniProt

site_id	PS00629
Number of Residues	13
Details	IMP_1 Inositol monophosphatase family signature 1. VwVDPLDGTkeY.T

Chain	Residue	Details
A	VAL114-THR126

---

site_id	PS00630
Number of Residues	15
Details	IMP_2 Inositol monophosphatase family signature 2. WDtCAPeVILhavGG

Chain	Residue	Details
A	TRP246-GLY260

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"Q9Z1N4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2009","submissionDatabase":"PDB data bank","title":"Human 3'(2'), 5'-bisphosphate nucleotidase 1 (BPNT1) in complex with AMP, PO4 and magnesium.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"2WEF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9Z0S1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ima

Chain	Residue	Details
A	GLU74
A	THR122

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1ima

Chain	Residue	Details
A	ASP51
A	THR122
A	ASP247

---