2WEA

ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE INHIBITOR: METHYL[CYCLO-7[(2R)-((N-VALYL) AMINO)-2-(HYDROXYL-(1S)-1-METHYOXYCARBONYL-2-PHENYLETHOXY) PHOSPHINYLOXY-ETHYL]-1-NAPHTHALENEACETAMIDE], SODIUM SALT

Replaces:  1WEA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	CIC
Number of Residues	2
Details	CATALYTIC SITE.

Chain	Residue
A	ASP33
A	ASP213

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LNFDTGSADLWV

Chain	Residue	Details
A	LEU30-VAL41
A	GLY210-LEU221

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01103, ECO:0000269|PubMed:5475460

Chain	Residue	Details
A	ASP33
A	ASP213

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: O-linked (Man...) serine => ECO:0000269|PubMed:9836576, ECO:0000269|DOI:10.1021/ja973714r

Chain	Residue	Details
A	SER3

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: O-linked (Man...) threonine => ECO:0000269|PubMed:9836576, ECO:0000269|DOI:10.1021/ja973714r

Chain	Residue	Details
A	THR7

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