2WDZ
Crystal structure of the short chain dehydrogenase Galactitol- Dehydrogenase (GatDH) of Rhodobacter sphaeroides in complex with NAD+ and 1,2-Pentandiol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG A 255 |
| Chain | Residue |
| A | TRP254 |
| A | TRP254 |
| A | HOH2143 |
| A | HOH2143 |
| A | HOH2145 |
| A | HOH2145 |
| A | HOH2146 |
| A | HOH2146 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAD A 257 |
| Chain | Residue |
| A | SER21 |
| A | GLY22 |
| A | ILE23 |
| A | ASP42 |
| A | ARG43 |
| A | ALA65 |
| A | ASP66 |
| A | VAL67 |
| A | SER92 |
| A | ALA93 |
| A | LEU142 |
| A | GLY143 |
| A | SER144 |
| A | TYR159 |
| A | LYS163 |
| A | PRO189 |
| A | GLY190 |
| A | VAL192 |
| A | THR194 |
| A | MET196 |
| A | THR197 |
| A | 1SP258 |
| A | HOH2147 |
| A | HOH2148 |
| A | HOH2149 |
| A | HOH2150 |
| A | GLY18 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 1SP A 258 |
| Chain | Residue |
| A | SER144 |
| A | SER146 |
| A | ASN151 |
| A | TYR159 |
| A | THR197 |
| A | NAD257 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1SP A 259 |
| Chain | Residue |
| A | ALA45 |
| A | ASP49 |
| A | ARG62 |
| D | ALA45 |
| D | LEU48 |
| D | ASP49 |
| D | ARG62 |
| D | VAL64 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG B 255 |
| Chain | Residue |
| B | TRP254 |
| B | TRP254 |
| B | HOH2111 |
| B | HOH2111 |
| B | HOH2114 |
| B | HOH2114 |
| B | HOH2116 |
| B | HOH2116 |
| site_id | AC6 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAD B 257 |
| Chain | Residue |
| B | GLY18 |
| B | SER21 |
| B | GLY22 |
| B | ILE23 |
| B | ASP42 |
| B | ARG43 |
| B | ALA65 |
| B | ASP66 |
| B | VAL67 |
| B | SER92 |
| B | ALA93 |
| B | GLY94 |
| B | VAL115 |
| B | LEU142 |
| B | GLY143 |
| B | SER144 |
| B | TYR159 |
| B | LYS163 |
| B | PRO189 |
| B | GLY190 |
| B | VAL192 |
| B | THR194 |
| B | GLU195 |
| B | MET196 |
| B | THR197 |
| B | 1SP258 |
| B | HOH2013 |
| B | HOH2117 |
| B | HOH2119 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE 1SP B 258 |
| Chain | Residue |
| B | SER144 |
| B | SER146 |
| B | ASN151 |
| B | TYR159 |
| B | NAD257 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 256 |
| Chain | Residue |
| C | TRP254 |
| C | HOH2101 |
| C | HOH2104 |
| C | HOH2105 |
| C | HOH2106 |
| D | TRP254 |
| site_id | AC9 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAD C 257 |
| Chain | Residue |
| D | GLY18 |
| D | SER21 |
| D | GLY22 |
| D | ILE23 |
| D | ASP42 |
| D | ARG43 |
| D | ALA65 |
| D | ASP66 |
| D | VAL67 |
| D | SER92 |
| D | ALA93 |
| D | ILE95 |
| D | VAL115 |
| D | LEU142 |
| D | GLY143 |
| D | SER144 |
| D | TYR159 |
| D | LYS163 |
| D | PRO189 |
| D | GLY190 |
| D | VAL192 |
| D | THR194 |
| D | GLU195 |
| D | MET196 |
| D | THR197 |
| C | 1SP258 |
| C | HOH2108 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 1SP C 258 |
| Chain | Residue |
| C | NAD257 |
| D | SER144 |
| D | MET145 |
| D | SER146 |
| D | ASN151 |
| D | TYR159 |
| D | THR197 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 256 |
| Chain | Residue |
| C | TRP254 |
| C | HOH2101 |
| C | HOH2104 |
| C | HOH2105 |
| C | HOH2106 |
| D | TRP254 |
| site_id | BC3 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAD D 257 |
| Chain | Residue |
| C | GLY18 |
| C | SER21 |
| C | GLY22 |
| C | ILE23 |
| C | ASP42 |
| C | ARG43 |
| C | ALA65 |
| C | ASP66 |
| C | VAL67 |
| C | SER92 |
| C | ALA93 |
| C | GLY94 |
| C | VAL115 |
| C | LEU142 |
| C | GLY143 |
| C | SER144 |
| C | TYR159 |
| C | LYS163 |
| C | PRO189 |
| C | GLY190 |
| C | VAL192 |
| C | THR194 |
| C | GLU195 |
| C | MET196 |
| C | THR197 |
| C | HOH2041 |
| D | 1SP258 |
| D | HOH2116 |
| D | HOH2117 |
| D | HOH2118 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE 1SP D 258 |
| Chain | Residue |
| C | SER144 |
| C | SER146 |
| C | TYR159 |
| D | NAD257 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"20410293","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20410293","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WSB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
