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2WC8

S100A12 complex with zinc in the absence of calcium

Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0002548biological_processmonocyte chemotaxis
A0005507molecular_functioncopper ion binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006805biological_processxenobiotic metabolic process
A0006954biological_processinflammatory response
A0008270molecular_functionzinc ion binding
A0016020cellular_componentmembrane
A0030593biological_processneutrophil chemotaxis
A0031640biological_processkilling of cells of another organism
A0034774cellular_componentsecretory granule lumen
A0042742biological_processdefense response to bacterium
A0042802molecular_functionidentical protein binding
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043406biological_processpositive regulation of MAP kinase activity
A0043542biological_processendothelial cell migration
A0045087biological_processinnate immune response
A0045576biological_processmast cell activation
A0046872molecular_functionmetal ion binding
A0048306molecular_functioncalcium-dependent protein binding
A0050729biological_processpositive regulation of inflammatory response
A0050786molecular_functionRAGE receptor binding
A0050832biological_processdefense response to fungus
A0051092biological_processpositive regulation of NF-kappaB transcription factor activity
A0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
B0002376biological_processimmune system process
B0002548biological_processmonocyte chemotaxis
B0005507molecular_functioncopper ion binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0006805biological_processxenobiotic metabolic process
B0006954biological_processinflammatory response
B0008270molecular_functionzinc ion binding
B0016020cellular_componentmembrane
B0030593biological_processneutrophil chemotaxis
B0031640biological_processkilling of cells of another organism
B0034774cellular_componentsecretory granule lumen
B0042742biological_processdefense response to bacterium
B0042802molecular_functionidentical protein binding
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043406biological_processpositive regulation of MAP kinase activity
B0043542biological_processendothelial cell migration
B0045087biological_processinnate immune response
B0045576biological_processmast cell activation
B0046872molecular_functionmetal ion binding
B0048306molecular_functioncalcium-dependent protein binding
B0050729biological_processpositive regulation of inflammatory response
B0050786molecular_functionRAGE receptor binding
B0050832biological_processdefense response to fungus
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
C0002376biological_processimmune system process
C0002548biological_processmonocyte chemotaxis
C0005507molecular_functioncopper ion binding
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0006805biological_processxenobiotic metabolic process
C0006954biological_processinflammatory response
C0008270molecular_functionzinc ion binding
C0016020cellular_componentmembrane
C0030593biological_processneutrophil chemotaxis
C0031640biological_processkilling of cells of another organism
C0034774cellular_componentsecretory granule lumen
C0042742biological_processdefense response to bacterium
C0042802molecular_functionidentical protein binding
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043406biological_processpositive regulation of MAP kinase activity
C0043542biological_processendothelial cell migration
C0045087biological_processinnate immune response
C0045576biological_processmast cell activation
C0046872molecular_functionmetal ion binding
C0048306molecular_functioncalcium-dependent protein binding
C0050729biological_processpositive regulation of inflammatory response
C0050786molecular_functionRAGE receptor binding
C0050832biological_processdefense response to fungus
C0051092biological_processpositive regulation of NF-kappaB transcription factor activity
C0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
D0002376biological_processimmune system process
D0002548biological_processmonocyte chemotaxis
D0005507molecular_functioncopper ion binding
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0006805biological_processxenobiotic metabolic process
D0006954biological_processinflammatory response
D0008270molecular_functionzinc ion binding
D0016020cellular_componentmembrane
D0030593biological_processneutrophil chemotaxis
D0031640biological_processkilling of cells of another organism
D0034774cellular_componentsecretory granule lumen
D0042742biological_processdefense response to bacterium
D0042802molecular_functionidentical protein binding
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0043406biological_processpositive regulation of MAP kinase activity
D0043542biological_processendothelial cell migration
D0045087biological_processinnate immune response
D0045576biological_processmast cell activation
D0046872molecular_functionmetal ion binding
D0048306molecular_functioncalcium-dependent protein binding
D0050729biological_processpositive regulation of inflammatory response
D0050786molecular_functionRAGE receptor binding
D0050832biological_processdefense response to fungus
D0051092biological_processpositive regulation of NF-kappaB transcription factor activity
D0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA A 92
ChainResidue
ASER18
ALYS21
AHIS23
ATHR26
AHOH2042
AHOH2063

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 95
ChainResidue
BHIS89
AHIS15
AASP25
BHIS85

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA B 92
ChainResidue
CSER18
CLYS21
CHIS23
CTHR26
CHOH2051
CHOH2092

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 95
ChainResidue
AHIS85
AHIS89
BHIS15
BASP25

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA C 92
ChainResidue
BSER18
BLYS21
BHIS23
BTHR26
BHOH2055
BHOH2108

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 95
ChainResidue
CHIS15
CASP25
DHIS85
DHIS89

site_idAC7
Number of Residues9
DetailsBINDING SITE FOR RESIDUE CIT C 1092
ChainResidue
CILE74
CSER75
CHOH2115
CHOH2116
CHOH2117
CHOH2118
CHOH2119
DLYS50
DSER75

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA D 92
ChainResidue
DSER18
DLYS21
DHIS23
DTHR26
DHOH2057
DHOH2110

site_idAC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 95
ChainResidue
CHIS85
CHIS89
DHIS15
DASP25

Functional Information from PROSITE/UniProt
site_idPS00303
Number of Residues22
DetailsS100_CABP S-100/ICaBP type calcium binding protein signature. IFqgLDanqDeqvDFqEFisLV
ChainResidueDetails
AILE56-VAL77

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:19501594, ECO:0007744|PDB:2WC8, ECO:0007744|PDB:2WCB
ChainResidueDetails
AHIS15
CASP25
CHIS85
CHIS89
DHIS15
DASP25
DHIS85
DHIS89
AASP25
AHIS85
AHIS89
BHIS15
BASP25
BHIS85
BHIS89
CHIS15

site_idSWS_FT_FI2
Number of Residues40
DetailsBINDING: BINDING => ECO:0000269|PubMed:11134923, ECO:0000269|PubMed:12777802, ECO:0007744|PDB:1E8A, ECO:0007744|PDB:1ODB
ChainResidueDetails
ASER18
AGLU72
BSER18
BLYS21
BHIS23
BTHR26
BGLU31
BASP61
BASN63
BASP65
BGLN67
ALYS21
BGLU72
CSER18
CLYS21
CHIS23
CTHR26
CGLU31
CASP61
CASN63
CASP65
CGLN67
AHIS23
CGLU72
DSER18
DLYS21
DHIS23
DTHR26
DGLU31
DASP61
DASN63
DASP65
DGLN67
ATHR26
DGLU72
AGLU31
AASP61
AASN63
AASP65
AGLN67

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PDB entries from 2025-06-11

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