Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0015036 | molecular_function | disulfide oxidoreductase activity |
| A | 0015042 | molecular_function | trypanothione-disulfide reductase (NADPH) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0015036 | molecular_function | disulfide oxidoreductase activity |
| B | 0015042 | molecular_function | trypanothione-disulfide reductase (NADPH) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE FAD A 1491 |
| Chain | Residue |
| A | ILE10 |
| A | GLY50 |
| A | THR51 |
| A | CYS52 |
| A | CYS57 |
| A | LYS60 |
| A | GLY127 |
| A | ALA159 |
| A | THR160 |
| A | GLY161 |
| A | ARG287 |
| A | GLY11 |
| A | ARG290 |
| A | GLY326 |
| A | ASP327 |
| A | MET333 |
| A | LEU334 |
| A | THR335 |
| A | PRO336 |
| A | HOH2164 |
| A | HOH2247 |
| A | HOH2269 |
| A | GLY13 |
| A | HOH2373 |
| A | HOH2374 |
| A | HOH2375 |
| A | HOH2376 |
| A | HOH2377 |
| B | HIS461 |
| A | SER14 |
| A | GLY15 |
| A | VAL34 |
| A | ASP35 |
| A | ALA46 |
| A | ALA47 |
| site_id | AC2 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE FAD B 1491 |
| Chain | Residue |
| A | HIS461 |
| A | HOH2357 |
| B | ILE10 |
| B | GLY11 |
| B | GLY13 |
| B | SER14 |
| B | GLY15 |
| B | VAL34 |
| B | ASP35 |
| B | VAL36 |
| B | ALA46 |
| B | ALA47 |
| B | GLY50 |
| B | THR51 |
| B | CYS52 |
| B | CYS57 |
| B | LYS60 |
| B | GLY125 |
| B | TRP126 |
| B | GLY127 |
| B | ALA159 |
| B | THR160 |
| B | GLY161 |
| B | ARG287 |
| B | ARG290 |
| B | GLY326 |
| B | ASP327 |
| B | MET333 |
| B | LEU334 |
| B | THR335 |
| B | PRO336 |
| B | HOH2283 |
| B | HOH2383 |
| B | HOH2384 |
| B | HOH2385 |
| B | HOH2386 |
| B | HOH2387 |
| B | HOH2388 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1492 |
| Chain | Residue |
| A | GLU18 |
| A | TYR110 |
| A | HOH2378 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 1492 |
| Chain | Residue |
| B | SER109 |
| B | TYR110 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1493 |
| Chain | Residue |
| A | SER470 |
| A | ARG472 |
| A | THR473 |
| A | HOH2368 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 1493 |
| Chain | Residue |
| B | TRP163 |
| B | ARG290 |
| B | ASP293 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1494 |
| Chain | Residue |
| B | GLU139 |
| B | PRO213 |
| B | HOH2189 |
| B | HOH2389 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 1495 |
| Chain | Residue |
| B | GLU18 |
| B | TYR110 |
| B | HOH2390 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL A 1494 |
| Chain | Residue |
| A | SER109 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1495 |
| Chain | Residue |
| A | ARG290 |
| A | ASP293 |
| A | HOH2379 |
| A | HOH2380 |
| A | HOH2381 |
| site_id | BC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE NDP B 1496 |
| Chain | Residue |
| B | GLY197 |
| B | TYR221 |
| B | ARG222 |
| B | ASN223 |
| B | ARG228 |
| B | ASN254 |
| B | ALA284 |
| B | ILE285 |
| B | GLY286 |
| B | ARG287 |
| B | HOH2391 |
| B | HOH2393 |
| B | HOH2394 |
| B | HOH2395 |
| B | HOH2396 |
| B | GLY196 |
| site_id | BC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE NDP A 1496 |
| Chain | Residue |
| A | GLY196 |
| A | GLY197 |
| A | TYR221 |
| A | ARG222 |
| A | ASN223 |
| A | ARG228 |
| A | ASN254 |
| A | ALA284 |
| A | ILE285 |
| A | GLY286 |
| A | HOH2382 |
| A | HOH2383 |
| A | HOH2384 |
| A | HOH2385 |
| A | HOH2387 |
| site_id | BC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PG4 A 1497 |
| Chain | Residue |
| A | VAL311 |
| A | ASP312 |
| A | ARG316 |
| A | THR317 |
| A | HOH2388 |
| A | HOH2389 |
| B | ASP312 |
| B | ARG316 |
| B | THR317 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1497 |
| Chain | Residue |
| B | ARG189 |
| B | ARG190 |
| B | HOH2253 |
| B | HOH2397 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1498 |
| Chain | Residue |
| A | ARG189 |
| A | ARG190 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP |
| Chain | Residue | Details |
| A | GLY49-PRO59 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 34 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | CYS52 | |
| A | CYS57 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| B | CYS52 | |
| B | CYS57 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | GLU466 | |
| A | HIS461 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| B | GLU466 | |
| B | HIS461 |
