Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005829 | cellular_component | cytosol |
A | 0006749 | biological_process | glutathione metabolic process |
A | 0015036 | molecular_function | disulfide oxidoreductase activity |
A | 0015042 | molecular_function | trypanothione-disulfide reductase (NADPH) activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
A | 0034599 | biological_process | cellular response to oxidative stress |
A | 0045454 | biological_process | cell redox homeostasis |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 0098869 | biological_process | cellular oxidant detoxification |
B | 0004362 | molecular_function | glutathione-disulfide reductase (NADPH) activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005829 | cellular_component | cytosol |
B | 0006749 | biological_process | glutathione metabolic process |
B | 0015036 | molecular_function | disulfide oxidoreductase activity |
B | 0015042 | molecular_function | trypanothione-disulfide reductase (NADPH) activity |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
B | 0034599 | biological_process | cellular response to oxidative stress |
B | 0045454 | biological_process | cell redox homeostasis |
B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
B | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 35 |
Details | BINDING SITE FOR RESIDUE FAD A 1491 |
Chain | Residue |
A | ILE10 |
A | GLY50 |
A | THR51 |
A | CYS52 |
A | CYS57 |
A | LYS60 |
A | GLY127 |
A | ALA159 |
A | THR160 |
A | GLY161 |
A | ARG287 |
A | GLY11 |
A | ARG290 |
A | GLY326 |
A | ASP327 |
A | MET333 |
A | LEU334 |
A | THR335 |
A | PRO336 |
A | HOH2164 |
A | HOH2247 |
A | HOH2269 |
A | GLY13 |
A | HOH2373 |
A | HOH2374 |
A | HOH2375 |
A | HOH2376 |
A | HOH2377 |
B | HIS461 |
A | SER14 |
A | GLY15 |
A | VAL34 |
A | ASP35 |
A | ALA46 |
A | ALA47 |
site_id | AC2 |
Number of Residues | 38 |
Details | BINDING SITE FOR RESIDUE FAD B 1491 |
Chain | Residue |
A | HIS461 |
A | HOH2357 |
B | ILE10 |
B | GLY11 |
B | GLY13 |
B | SER14 |
B | GLY15 |
B | VAL34 |
B | ASP35 |
B | VAL36 |
B | ALA46 |
B | ALA47 |
B | GLY50 |
B | THR51 |
B | CYS52 |
B | CYS57 |
B | LYS60 |
B | GLY125 |
B | TRP126 |
B | GLY127 |
B | ALA159 |
B | THR160 |
B | GLY161 |
B | ARG287 |
B | ARG290 |
B | GLY326 |
B | ASP327 |
B | MET333 |
B | LEU334 |
B | THR335 |
B | PRO336 |
B | HOH2283 |
B | HOH2383 |
B | HOH2384 |
B | HOH2385 |
B | HOH2386 |
B | HOH2387 |
B | HOH2388 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 1492 |
Chain | Residue |
A | GLU18 |
A | TYR110 |
A | HOH2378 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL B 1492 |
Chain | Residue |
B | SER109 |
B | TYR110 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL A 1493 |
Chain | Residue |
A | SER470 |
A | ARG472 |
A | THR473 |
A | HOH2368 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 1493 |
Chain | Residue |
B | TRP163 |
B | ARG290 |
B | ASP293 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL B 1494 |
Chain | Residue |
B | GLU139 |
B | PRO213 |
B | HOH2189 |
B | HOH2389 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL B 1495 |
Chain | Residue |
B | GLU18 |
B | TYR110 |
B | HOH2390 |
site_id | AC9 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE GOL A 1494 |
Chain | Residue |
A | SER109 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 1495 |
Chain | Residue |
A | ARG290 |
A | ASP293 |
A | HOH2379 |
A | HOH2380 |
A | HOH2381 |
site_id | BC2 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE NDP B 1496 |
Chain | Residue |
B | GLY197 |
B | TYR221 |
B | ARG222 |
B | ASN223 |
B | ARG228 |
B | ASN254 |
B | ALA284 |
B | ILE285 |
B | GLY286 |
B | ARG287 |
B | HOH2391 |
B | HOH2393 |
B | HOH2394 |
B | HOH2395 |
B | HOH2396 |
B | GLY196 |
site_id | BC3 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE NDP A 1496 |
Chain | Residue |
A | GLY196 |
A | GLY197 |
A | TYR221 |
A | ARG222 |
A | ASN223 |
A | ARG228 |
A | ASN254 |
A | ALA284 |
A | ILE285 |
A | GLY286 |
A | HOH2382 |
A | HOH2383 |
A | HOH2384 |
A | HOH2385 |
A | HOH2387 |
site_id | BC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PG4 A 1497 |
Chain | Residue |
A | VAL311 |
A | ASP312 |
A | ARG316 |
A | THR317 |
A | HOH2388 |
A | HOH2389 |
B | ASP312 |
B | ARG316 |
B | THR317 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 1497 |
Chain | Residue |
B | ARG189 |
B | ARG190 |
B | HOH2253 |
B | HOH2397 |
site_id | BC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 1498 |
Chain | Residue |
A | ARG189 |
A | ARG190 |
Functional Information from PROSITE/UniProt
site_id | PS00076 |
Number of Residues | 11 |
Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP |
Chain | Residue | Details |
A | GLY49-PRO59 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000250 |
Chain | Residue | Details |
A | HIS461 | |
B | HIS461 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | ASP35 | |
B | ASP35 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
A | CYS52 | |
A | CYS57 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
B | CYS52 | |
B | CYS57 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
A | GLU466 | |
A | HIS461 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1get |
Chain | Residue | Details |
B | GLU466 | |
B | HIS461 |