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2W9F

Crystal Structure of CDK4 in complex with a D-type cyclin

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
A0000320biological_processre-entry into mitotic cell cycle
A0001934biological_processpositive regulation of protein phosphorylation
A0003714molecular_functiontranscription corepressor activity
A0004672molecular_functionprotein kinase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005923cellular_componentbicellular tight junction
A0006974biological_processDNA damage response
A0007595biological_processlactation
A0008283biological_processcell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0010971biological_processpositive regulation of G2/M transition of mitotic cell cycle
A0016020cellular_componentmembrane
A0016055biological_processWnt signaling pathway
A0016301molecular_functionkinase activity
A0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
A0017053cellular_componenttranscription repressor complex
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0030182biological_processneuron differentiation
A0030857biological_processnegative regulation of epithelial cell differentiation
A0030968biological_processendoplasmic reticulum unfolded protein response
A0031571biological_processmitotic G1 DNA damage checkpoint signaling
A0031965cellular_componentnuclear membrane
A0033598biological_processmammary gland epithelial cell proliferation
A0033601biological_processpositive regulation of mammary gland epithelial cell proliferation
A0042826molecular_functionhistone deacetylase binding
A0043524biological_processnegative regulation of neuron apoptotic process
A0044321biological_processresponse to leptin
A0045444biological_processfat cell differentiation
A0045737biological_processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
A0051301biological_processcell division
A0051726biological_processregulation of cell cycle
A0060749biological_processmammary gland alveolus development
A0061575molecular_functioncyclin-dependent protein serine/threonine kinase activator activity
A0070064molecular_functionproline-rich region binding
A0070141biological_processresponse to UV-A
A0097128cellular_componentcyclin D1-CDK4 complex
A0097131cellular_componentcyclin D1-CDK6 complex
A0097421biological_processliver regeneration
A1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
A2000045biological_processregulation of G1/S transition of mitotic cell cycle
B0000082biological_processG1/S transition of mitotic cell cycle
B0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
B0000785cellular_componentchromatin
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005667cellular_componenttranscription regulator complex
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005923cellular_componentbicellular tight junction
B0006468biological_processprotein phosphorylation
B0007165biological_processsignal transduction
B0008284biological_processpositive regulation of cell population proliferation
B0009410biological_processresponse to xenobiotic stimulus
B0010389biological_processregulation of G2/M transition of mitotic cell cycle
B0010468biological_processregulation of gene expression
B0010971biological_processpositive regulation of G2/M transition of mitotic cell cycle
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
B0030332molecular_functioncyclin binding
B0031965cellular_componentnuclear membrane
B0048146biological_processpositive regulation of fibroblast proliferation
B0051301biological_processcell division
B0051726biological_processregulation of cell cycle
B0060260biological_processregulation of transcription initiation by RNA polymerase II
B0061469biological_processregulation of type B pancreatic cell proliferation
B0071222biological_processcellular response to lipopolysaccharide
B0071353biological_processcellular response to interleukin-4
B0097128cellular_componentcyclin D1-CDK4 complex
B0097129cellular_componentcyclin D2-CDK4 complex
B0097130cellular_componentcyclin D3-CDK4 complex
B0106310molecular_functionprotein serine kinase activity
B1904628biological_processcellular response to phorbol 13-acetate 12-myristate
B1904637biological_processcellular response to ionomycin
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGVGAYGTVYkArdphsghf..........VALK
ChainResidueDetails
BILE12-LYS35

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNILV
ChainResidueDetails
BILE136-VAL148

site_idPS00292
Number of Residues32
DetailsCYCLINS Cyclins signature. RkiVatWMlevceeqkCeeevFplAMnYLDRF
ChainResidueDetails
AARG57-PHE88

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
BASP140

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
BILE12
BLYS35

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330
ChainResidueDetails
BALA2

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:16782892, ECO:0000269|PubMed:19237555, ECO:0000269|PubMed:19237565, ECO:0000269|PubMed:19487459, ECO:0007744|PubMed:19369195
ChainResidueDetails
BPHE172

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BASP140
BGLU144

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BLYS142
BASP140

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BLYS142
BTHR177
BASP140

site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
BLYS142
BASN145
BASP140

226707

PDB entries from 2024-10-30

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