2W73

High-resolution structure of the complex between calmodulin and a peptide from calcineurin A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000086	biological_process	G2/M transition of mitotic cell cycle
A	0000922	cellular_component	spindle pole
A	0002027	biological_process	regulation of heart rate
A	0005509	molecular_function	calcium ion binding
A	0005513	biological_process	detection of calcium ion
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005876	cellular_component	spindle microtubule
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
A	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
A	0010856	molecular_function	adenylate cyclase activator activity
A	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A	0016020	cellular_component	membrane
A	0016240	biological_process	autophagosome membrane docking
A	0019855	molecular_function	calcium channel inhibitor activity
A	0019901	molecular_function	protein kinase binding
A	0021762	biological_process	substantia nigra development
A	0030017	cellular_component	sarcomere
A	0030234	molecular_function	enzyme regulator activity
A	0031432	molecular_function	titin binding
A	0031514	cellular_component	motile cilium
A	0031954	biological_process	positive regulation of protein autophosphorylation
A	0031982	cellular_component	vesicle
A	0032465	biological_process	regulation of cytokinesis
A	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
A	0032991	cellular_component	protein-containing complex
A	0034704	cellular_component	calcium channel complex
A	0035307	biological_process	positive regulation of protein dephosphorylation
A	0035458	biological_process	cellular response to interferon-beta
A	0042995	cellular_component	cell projection
A	0043209	cellular_component	myelin sheath
A	0043539	molecular_function	protein serine/threonine kinase activator activity
A	0044325	molecular_function	transmembrane transporter binding
A	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
A	0046872	molecular_function	metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0050848	biological_process	regulation of calcium-mediated signaling
A	0051343	biological_process	positive regulation of cyclic-nucleotide phosphodiesterase activity
A	0051592	biological_process	response to calcium ion
A	0055117	biological_process	regulation of cardiac muscle contraction
A	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
A	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
A	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
A	0071346	biological_process	cellular response to type II interferon
A	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
A	0072542	molecular_function	protein phosphatase activator activity
A	0097225	cellular_component	sperm midpiece
A	0098901	biological_process	regulation of cardiac muscle cell action potential
A	0140056	biological_process	organelle localization by membrane tethering
A	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
A	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
A	1902494	cellular_component	catalytic complex
A	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
A	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
B	0000086	biological_process	G2/M transition of mitotic cell cycle
B	0000922	cellular_component	spindle pole
B	0002027	biological_process	regulation of heart rate
B	0005509	molecular_function	calcium ion binding
B	0005513	biological_process	detection of calcium ion
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005819	cellular_component	spindle
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005876	cellular_component	spindle microtubule
B	0005886	cellular_component	plasma membrane
B	0005929	cellular_component	cilium
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
B	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
B	0010856	molecular_function	adenylate cyclase activator activity
B	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B	0016020	cellular_component	membrane
B	0016240	biological_process	autophagosome membrane docking
B	0019855	molecular_function	calcium channel inhibitor activity
B	0019901	molecular_function	protein kinase binding
B	0021762	biological_process	substantia nigra development
B	0030017	cellular_component	sarcomere
B	0030234	molecular_function	enzyme regulator activity
B	0031432	molecular_function	titin binding
B	0031514	cellular_component	motile cilium
B	0031954	biological_process	positive regulation of protein autophosphorylation
B	0031982	cellular_component	vesicle
B	0032465	biological_process	regulation of cytokinesis
B	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
B	0032991	cellular_component	protein-containing complex
B	0034704	cellular_component	calcium channel complex
B	0035307	biological_process	positive regulation of protein dephosphorylation
B	0035458	biological_process	cellular response to interferon-beta
B	0042995	cellular_component	cell projection
B	0043209	cellular_component	myelin sheath
B	0043539	molecular_function	protein serine/threonine kinase activator activity
B	0044325	molecular_function	transmembrane transporter binding
B	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
B	0046872	molecular_function	metal ion binding
B	0048306	molecular_function	calcium-dependent protein binding
B	0050848	biological_process	regulation of calcium-mediated signaling
B	0051343	biological_process	positive regulation of cyclic-nucleotide phosphodiesterase activity
B	0051592	biological_process	response to calcium ion
B	0055117	biological_process	regulation of cardiac muscle contraction
B	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
B	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
B	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
B	0071346	biological_process	cellular response to type II interferon
B	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
B	0072542	molecular_function	protein phosphatase activator activity
B	0097225	cellular_component	sperm midpiece
B	0098901	biological_process	regulation of cardiac muscle cell action potential
B	0140056	biological_process	organelle localization by membrane tethering
B	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
B	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
B	1902494	cellular_component	catalytic complex
B	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
B	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
E	0000086	biological_process	G2/M transition of mitotic cell cycle
E	0000922	cellular_component	spindle pole
E	0002027	biological_process	regulation of heart rate
E	0005509	molecular_function	calcium ion binding
E	0005513	biological_process	detection of calcium ion
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005876	cellular_component	spindle microtubule
E	0005886	cellular_component	plasma membrane
E	0005929	cellular_component	cilium
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
E	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
E	0010856	molecular_function	adenylate cyclase activator activity
E	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E	0016020	cellular_component	membrane
E	0016240	biological_process	autophagosome membrane docking
E	0019855	molecular_function	calcium channel inhibitor activity
E	0019901	molecular_function	protein kinase binding
E	0021762	biological_process	substantia nigra development
E	0030017	cellular_component	sarcomere
E	0030234	molecular_function	enzyme regulator activity
E	0031432	molecular_function	titin binding
E	0031514	cellular_component	motile cilium
E	0031954	biological_process	positive regulation of protein autophosphorylation
E	0031982	cellular_component	vesicle
E	0032465	biological_process	regulation of cytokinesis
E	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
E	0032991	cellular_component	protein-containing complex
E	0034704	cellular_component	calcium channel complex
E	0035307	biological_process	positive regulation of protein dephosphorylation
E	0035458	biological_process	cellular response to interferon-beta
E	0042995	cellular_component	cell projection
E	0043209	cellular_component	myelin sheath
E	0043539	molecular_function	protein serine/threonine kinase activator activity
E	0044325	molecular_function	transmembrane transporter binding
E	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
E	0046872	molecular_function	metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0050848	biological_process	regulation of calcium-mediated signaling
E	0051343	biological_process	positive regulation of cyclic-nucleotide phosphodiesterase activity
E	0051592	biological_process	response to calcium ion
E	0055117	biological_process	regulation of cardiac muscle contraction
E	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
E	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
E	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
E	0071346	biological_process	cellular response to type II interferon
E	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
E	0072542	molecular_function	protein phosphatase activator activity
E	0097225	cellular_component	sperm midpiece
E	0098901	biological_process	regulation of cardiac muscle cell action potential
E	0140056	biological_process	organelle localization by membrane tethering
E	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
E	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
E	1902494	cellular_component	catalytic complex
E	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
E	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
F	0000086	biological_process	G2/M transition of mitotic cell cycle
F	0000922	cellular_component	spindle pole
F	0002027	biological_process	regulation of heart rate
F	0005509	molecular_function	calcium ion binding
F	0005513	biological_process	detection of calcium ion
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005876	cellular_component	spindle microtubule
F	0005886	cellular_component	plasma membrane
F	0005929	cellular_component	cilium
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0008076	cellular_component	voltage-gated potassium channel complex
F	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
F	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
F	0010856	molecular_function	adenylate cyclase activator activity
F	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F	0016020	cellular_component	membrane
F	0016240	biological_process	autophagosome membrane docking
F	0019855	molecular_function	calcium channel inhibitor activity
F	0019901	molecular_function	protein kinase binding
F	0021762	biological_process	substantia nigra development
F	0030017	cellular_component	sarcomere
F	0030234	molecular_function	enzyme regulator activity
F	0031432	molecular_function	titin binding
F	0031514	cellular_component	motile cilium
F	0031954	biological_process	positive regulation of protein autophosphorylation
F	0031982	cellular_component	vesicle
F	0032465	biological_process	regulation of cytokinesis
F	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
F	0032991	cellular_component	protein-containing complex
F	0034704	cellular_component	calcium channel complex
F	0035307	biological_process	positive regulation of protein dephosphorylation
F	0035458	biological_process	cellular response to interferon-beta
F	0042995	cellular_component	cell projection
F	0043209	cellular_component	myelin sheath
F	0043539	molecular_function	protein serine/threonine kinase activator activity
F	0044325	molecular_function	transmembrane transporter binding
F	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
F	0046872	molecular_function	metal ion binding
F	0048306	molecular_function	calcium-dependent protein binding
F	0050848	biological_process	regulation of calcium-mediated signaling
F	0051343	biological_process	positive regulation of cyclic-nucleotide phosphodiesterase activity
F	0051592	biological_process	response to calcium ion
F	0055117	biological_process	regulation of cardiac muscle contraction
F	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
F	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
F	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
F	0071346	biological_process	cellular response to type II interferon
F	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
F	0072542	molecular_function	protein phosphatase activator activity
F	0097225	cellular_component	sperm midpiece
F	0098901	biological_process	regulation of cardiac muscle cell action potential
F	0140056	biological_process	organelle localization by membrane tethering
F	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
F	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
F	1902494	cellular_component	catalytic complex
F	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
F	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1148

Chain	Residue
A	ASP20
A	ASP22
A	ASP24
A	THR26
A	GLU31
A	HOH2015

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1149

Chain	Residue
A	THR62
A	GLU67
A	HOH2049
A	ASP56
A	ASP58
A	ASN60

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1150

Chain	Residue
A	ASP93
A	ASP95
A	ASN97
A	TYR99
A	GLU104
A	HOH2066

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1151

Chain	Residue
A	ASP129
A	ASP131
A	ASP133
A	GLN135
A	GLU140
A	HOH2079

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1148

Chain	Residue
B	ASP20
B	ASP22
B	ASP24
B	THR26
B	GLU31
B	HOH2016

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1149

Chain	Residue
B	ASP56
B	ASP58
B	ASN60
B	THR62
B	GLU67
B	HOH2056

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1150

Chain	Residue
B	ASP93
B	ASP95
B	ASN97
B	TYR99
B	GLU104
B	HOH2117

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 1151

Chain	Residue
B	ASP129
B	ASP131
B	ASP133
B	GLN135
B	GLU140
B	HOH2115

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 1152

Chain	Residue
B	ASN53
B	HOH2051
B	HOH2052
B	HOH2055

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA B 1153

Chain	Residue
B	HOH2035
B	HOH2107
B	HOH2108

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA B 1154

Chain	Residue
B	HOH2031
B	HOH2092
B	HOH2094

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 1148

Chain	Residue
E	ASP20
E	ASP22
E	ASP24
E	THR26
E	GLU31
E	HOH2014

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA E 1149

Chain	Residue
E	ASP56
E	ASP58
E	ASN60
E	THR62
E	GLU67
E	HOH2028
E	HOH2031

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 1150

Chain	Residue
E	ASP93
E	ASP95
E	ASN97
E	TYR99
E	GLU104
E	HOH2036

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 1151

Chain	Residue
E	ASP129
E	ASP131
E	ASP133
E	GLN135
E	GLU140
E	HOH2038

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 1148

Chain	Residue
F	ASP20
F	ASP22
F	ASP24
F	THR26
F	GLU31
F	HOH2020

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 1149

Chain	Residue
F	ASP56
F	ASP58
F	ASN60
F	THR62
F	GLU67
F	HOH2039

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 1150

Chain	Residue
F	GLU104
F	HOH2053
F	ASP93
F	ASP95
F	ASN97
F	TYR99

---

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 1151

Chain	Residue
F	ASP129
F	ASP131
F	ASP133
F	GLN135
F	GLU140
F	HOH2069

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA F 1152

Chain	Residue
F	ASP50
F	GLU54
F	HOH2035
F	HOH2036

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
A	ASP20-LEU32
A	ASP56-PHE68
A	ASP93-LEU105
A	ASP129-PHE141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03

Chain	Residue	Details
A	LYS21
A	PHE68
B	LYS21
B	GLY23
B	GLY25
B	ILE27
B	LEU32
B	ALA57
B	GLY59
B	GLY61
B	ILE63
A	GLY23
B	PHE68
E	LYS21
E	GLY23
E	GLY25
E	ILE27
E	LEU32
E	ALA57
E	GLY59
E	GLY61
E	ILE63
A	GLY25
E	PHE68
F	LYS21
F	GLY23
F	GLY25
F	ILE27
F	LEU32
F	ALA57
F	GLY59
F	GLY61
F	ILE63
A	ILE27
F	PHE68
A	LEU32
A	ALA57
A	GLY59
A	GLY61
A	ILE63

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03

Chain	Residue	Details
A	LYS94
A	PHE141
B	LYS94
B	GLY96
B	GLY98
B	ILE100
B	LEU105
B	ILE130
B	GLY132
B	GLY134
B	VAL136
A	GLY96
B	PHE141
E	LYS94
E	GLY96
E	GLY98
E	ILE100
E	LEU105
E	ILE130
E	GLY132
E	GLY134
E	VAL136
A	GLY98
E	PHE141
F	LYS94
F	GLY96
F	GLY98
F	ILE100
F	LEU105
F	ILE130
F	GLY132
F	GLY134
F	VAL136
A	ILE100
F	PHE141
A	LEU105
A	ILE130
A	GLY132
A	GLY134
A	VAL136

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712

Chain	Residue	Details
A	ASP2
B	ASP2
E	ASP2
F	ASP2

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	ASP22
B	ASP22
E	ASP22
F	ASP22

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29

Chain	Residue	Details
A	GLU45
B	GLU45
E	GLU45
F	GLU45

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	GLU82
B	GLU82
E	GLU82
F	GLU82

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	ASP95
B	ASP95
E	ASP95
F	ASP95

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	ILE100
B	ILE100
E	ILE100
F	ILE100

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	ALA102
B	ALA102
E	ALA102
F	ALA102

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	ASN111
B	ASN111
E	ASN111
F	ASN111

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315

Chain	Residue	Details
A	LEU116
B	LEU116
E	LEU116
F	LEU116

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	GLU139
B	GLU139
E	GLU139
F	GLU139

---

site_id	SWS_FT_FI13
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157

Chain	Residue	Details
A	ASP22
B	ASP22
E	ASP22
F	ASP22

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 406

Chain

Residue

Details

---

site_id	MCSA2
Number of Residues
Details	M-CSA 406

Chain

Residue

Details

---

site_id	MCSA3
Number of Residues
Details	M-CSA 406

Chain

Residue

Details

---

site_id	MCSA4
Number of Residues
Details	M-CSA 406

Chain

Residue

Details

---