2W5Y
Binary Complex of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A4970 |
| Chain | Residue |
| A | CYS3909 |
| A | CYS3957 |
| A | CYS3959 |
| A | CYS3964 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SAH A4971 |
| Chain | Residue |
| A | TYR3883 |
| A | ARG3903 |
| A | PHE3904 |
| A | ASN3906 |
| A | HIS3907 |
| A | TYR3944 |
| A | PRO3956 |
| A | ASN3958 |
| A | HOH2130 |
| A | ILE3838 |
| A | HIS3839 |
| A | GLY3840 |
| A | ARG3841 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:26886794, ECO:0007744|PDB:2W5Y, ECO:0007744|PDB:5F5E, ECO:0007744|PDB:5F6L |
| Chain | Residue | Details |
| A | HIS3839 | |
| A | ARG3841 | |
| A | ASN3958 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00190, ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:26886794, ECO:0007744|PDB:2W5Z, ECO:0007744|PDB:5F5E |
| Chain | Residue | Details |
| A | TYR3883 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:19187761, ECO:0000269|PubMed:26886794, ECO:0007744|PDB:2W5Y, ECO:0007744|PDB:5F5E, ECO:0007744|PDB:5F6L |
| Chain | Residue | Details |
| A | ASN3906 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16990798, ECO:0000269|PubMed:19187761, ECO:0007744|PDB:2W5Y, ECO:0007744|PDB:2W5Z, ECO:0007744|PDB:5F5E, ECO:0007744|PDB:5F6L |
| Chain | Residue | Details |
| A | CYS3909 | |
| A | CYS3957 | |
| A | CYS3959 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16990798, ECO:0000269|PubMed:19187761, ECO:0007744|PDB:2W5Y, ECO:0007744|PDB:2W5Z, ECO:0007744|PDB:5F6L |
| Chain | Residue | Details |
| A | CYS3964 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: S-methylcysteine; by autocatalysis => ECO:0000269|PubMed:24235145 |
| Chain | Residue | Details |
| A | CYS3882 |
