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2W5X

Structure of TAB5 alkaline phosphatase mutant His 135 Glu with Mg bound in the M3 site.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004035molecular_functionalkaline phosphatase activity
A0016311biological_processdephosphorylation
A0016791molecular_functionphosphatase activity
A0046872molecular_functionmetal ion binding
B0004035molecular_functionalkaline phosphatase activity
B0016311biological_processdephosphorylation
B0016791molecular_functionphosphatase activity
B0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A 1377
ChainResidue
ASEP84
AASP259
AHIS263
AHIS337
AHOH2352

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1378
ChainResidue
AASP43
ASEP84
AASP301
AHIS302

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 1379
ChainResidue
AASP43
AGLU135
ATHR137
AGLU254
AHOH2143
AHOH2144
AHOH2263

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 1380
ChainResidue
AASN266
ASER268
AHOH2244
AHOH2270
AHOH2272
AHOH2274

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN B 1377
ChainResidue
BSEP84
BASP259
BHIS263
BHIS337
BHOH2302

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 1378
ChainResidue
BASP43
BSEP84
BASP301
BHIS302

site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG B 1379
ChainResidue
BASP43
BGLU135
BTHR137
BGLU254
BHOH2116
BHOH2218
BHOH2300

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG B 1380
ChainResidue
BASN266
BSER268
BHOH2110
BHOH2202
BHOH2226
BHOH2228

Functional Information from PROSITE/UniProt
site_idPS00123
Number of Residues9
DetailsALKALINE_PHOSPHATASE Alkaline phosphatase active site. VtDSASGAT
ChainResidueDetails
AVAL81-THR89

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1alk
ChainResidueDetails
AARG148

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1alk
ChainResidueDetails
BARG148

226707

PDB entries from 2024-10-30

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