2W5E

Structural and biochemical analysis of human pathogenic astrovirus serine protease at 2.0 Angstrom resolution

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 1587

Chain	Residue
A	HIS-5
A	HIS-3
A	CYS515
A	CL1588

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1588

Chain	Residue
A	HIS-5
A	HIS-4
A	HIS-3
A	CD1587

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 1589

Chain	Residue
A	HIS-4
B	GLU474
F	HIS500
A	HIS-2

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1590

Chain	Residue
A	SER514
A	CYS515

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 1591

Chain	Residue
B	CYS472
B	MET477
B	CL1587

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1592

Chain	Residue
A	HIS-6
A	HOH2007
B	CYS472

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 1587

Chain	Residue
A	CD1591
B	LYS446

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD B 1588

Chain	Residue
B	HIS-5
B	HIS-3
B	CYS515
B	CL1589

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 1589

Chain	Residue
B	HIS-3
B	HIS-4
B	CD1588
C	HIS500

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD B 1590

Chain	Residue
A	GLU474
B	HIS-4
B	HIS-2
C	HIS500

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 1591

Chain	Residue
A	CYS472
A	CD1593
A	HOH2031
B	HIS-6

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD A 1593

Chain	Residue
A	CYS472
A	CL1594
A	HOH2021
B	HIS-6
B	LYS-7
B	CL1591

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1594

Chain	Residue
A	CYS472
A	MET477
A	CD1593
A	HOH2021

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 1592

Chain	Residue
B	SER514
B	CYS515
B	HOH2039

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD C 1587

Chain	Residue
C	HIS-4
C	HIS-2
D	GLU474
E	HIS500

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 1588

Chain	Residue
C	HIS-5
C	HIS-4
C	HIS-3
C	CD1589

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD C 1589

Chain	Residue
C	HIS-3
C	HIS-5
C	CYS515
C	CL1588

---

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 1590

Chain	Residue
C	SER514
C	CYS515

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 1591

Chain	Residue
C	HIS-6
C	CD1592
C	HOH2005
D	CYS472
D	HOH2017

---

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD C 1592

Chain	Residue
C	HIS-6
C	CL1591
D	CYS472
D	CL1587

---

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 1587

Chain	Residue
C	CD1592
D	VAL439
D	LYS446
D	CYS472

---

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 1588

Chain	Residue
C	HOH2002
D	LYS433
D	PRO434
D	GLY435

---

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD D 1589

Chain	Residue
A	HIS500
C	GLU474
D	HIS-2
D	HIS-4

---

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 1590

Chain	Residue
D	HIS-3
D	CD1591

---

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD D 1591

Chain	Residue
D	HIS-5
D	HIS-3
D	CYS515
D	CL1590

---

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 1592

Chain	Residue
D	SER514
D	CYS515
D	HOH2010

---

site_id	CC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 1593

Chain	Residue
C	LYS446
C	CD1594

---

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD C 1594

Chain	Residue
D	HIS-6
D	CL1593
C	CYS472
C	CL1593

---

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 1593

Chain	Residue
C	CYS472
C	CD1594
D	HIS-6
D	HOH2006

---

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 1595

Chain	Residue
C	LYS433
C	PRO434
C	GLY435
D	HOH2002

---

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD E 1587

Chain	Residue
B	HIS500
E	HIS-2
E	HIS-4
F	GLU474

---

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL E 1588

Chain	Residue
B	HIS500
E	HIS-3
E	HIS-4
E	CD1590

---

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 1589

Chain	Residue
C	HOH2046
E	SER514
E	CYS515

---

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD E 1590

Chain	Residue
E	HIS-3
E	HIS-5
E	CYS515
E	CL1588

---

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL E 1591

Chain	Residue
E	HIS-6
E	CD1592
E	HOH2006
F	CYS472
F	HOH2020

---

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CD E 1592

Chain	Residue
E	HIS-6
E	CL1591
F	CYS472
F	CL1587
F	HOH2013

---

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL F 1587

Chain	Residue
E	CD1592
F	CYS472
F	MET477
F	HOH2013
F	HOH2026

---

site_id	EC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL F 1588

Chain	Residue
E	HOH2003
F	LYS433
F	PRO434
F	GLY435

---

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL F 1589

Chain	Residue
D	HIS500
F	HIS-4
F	HIS-3
F	CD1592

---

site_id	EC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD F 1590

Chain	Residue
D	HIS500
E	GLU474
F	HIS-2
F	HIS-4

---

site_id	EC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL F 1591

Chain	Residue
E	CYS472
E	MET477
E	HOH2010
F	CD1594

---

site_id	EC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD F 1592

Chain	Residue
F	HIS-3
F	HIS-5
F	CYS515
F	CL1589

---

site_id	EC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL F 1593

Chain	Residue
E	CYS472
E	HOH2016
F	HIS-6
F	CD1594

---

site_id	EC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CD F 1594

Chain	Residue
E	CYS472
E	HOH2010
F	HIS-6
F	LYS-7
F	CL1591
F	CL1593

---

site_id	EC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL F 1595

Chain	Residue
D	HOH2028
F	SER514
F	CYS515
F	HOH2044

---

site_id	FC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL E 1593

Chain	Residue
E	LYS433
E	PRO434
E	GLY435
F	HOH2003

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Active site: {"description":"Charge relay system; for serine protease activity","evidences":[{"source":"PubMed","id":"19249313","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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