2W4M
The Crystal Structure of human N-acetylneuraminic acid phosphatase, NANP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006045 | biological_process | N-acetylglucosamine biosynthetic process |
| A | 0006054 | biological_process | N-acetylneuraminate metabolic process |
| A | 0006055 | biological_process | CMP-N-acetylneuraminate biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046380 | biological_process | N-acetylneuraminate biosynthetic process |
| A | 0050124 | molecular_function | N-acylneuraminate-9-phosphatase activity |
| A | 0070085 | biological_process | glycosylation |
| A | 1901137 | biological_process | carbohydrate derivative biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A1245 |
| Chain | Residue |
| A | ASP12 |
| A | ASP14 |
| A | ASP189 |
| A | CL1246 |
| A | PO41249 |
| A | HOH2075 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A1246 |
| Chain | Residue |
| A | HOH2088 |
| A | ASN15 |
| A | THR190 |
| A | NA1245 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A1247 |
| Chain | Residue |
| A | LYS55 |
| A | LYS58 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A1248 |
| Chain | Residue |
| A | ARG72 |
| A | ARG104 |
| A | LYS141 |
| A | HOH2085 |
| A | HOH2086 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 A1249 |
| Chain | Residue |
| A | ASP12 |
| A | LEU13 |
| A | ASP14 |
| A | THR131 |
| A | ASN132 |
| A | LYS164 |
| A | NA1245 |
| A | HOH2075 |
| A | HOH2087 |
| A | HOH2088 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23747226","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KNV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KNW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23747226","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KNV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23747226","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"PDB data bank","title":"The crystal structure of human N-acetylneuraminic acid phosphatase, NANP.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"2W4M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KNV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1lvh |
| Chain | Residue | Details |
| A | GLY133 | |
| A | LYS164 |
