Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2W4L

Human dCMP deaminase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004132	molecular_function	dCMP deaminase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006220	biological_process	pyrimidine nucleotide metabolic process
A	0006226	biological_process	dUMP biosynthetic process
A	0006231	biological_process	dTMP biosynthetic process
A	0008270	molecular_function	zinc ion binding
A	0009165	biological_process	nucleotide biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0043174	biological_process	nucleoside salvage
A	0046872	molecular_function	metal ion binding
A	0070694	molecular_function	5-hydroxymethyl-dUMP N-hydrolase activity
B	0003824	molecular_function	catalytic activity
B	0004132	molecular_function	dCMP deaminase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006220	biological_process	pyrimidine nucleotide metabolic process
B	0006226	biological_process	dUMP biosynthetic process
B	0006231	biological_process	dTMP biosynthetic process
B	0008270	molecular_function	zinc ion binding
B	0009165	biological_process	nucleotide biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0042802	molecular_function	identical protein binding
B	0043174	biological_process	nucleoside salvage
B	0046872	molecular_function	metal ion binding
B	0070694	molecular_function	5-hydroxymethyl-dUMP N-hydrolase activity
C	0003824	molecular_function	catalytic activity
C	0004132	molecular_function	dCMP deaminase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006220	biological_process	pyrimidine nucleotide metabolic process
C	0006226	biological_process	dUMP biosynthetic process
C	0006231	biological_process	dTMP biosynthetic process
C	0008270	molecular_function	zinc ion binding
C	0009165	biological_process	nucleotide biosynthetic process
C	0016787	molecular_function	hydrolase activity
C	0042802	molecular_function	identical protein binding
C	0043174	biological_process	nucleoside salvage
C	0046872	molecular_function	metal ion binding
C	0070694	molecular_function	5-hydroxymethyl-dUMP N-hydrolase activity
D	0003824	molecular_function	catalytic activity
D	0004132	molecular_function	dCMP deaminase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006220	biological_process	pyrimidine nucleotide metabolic process
D	0006226	biological_process	dUMP biosynthetic process
D	0006231	biological_process	dTMP biosynthetic process
D	0008270	molecular_function	zinc ion binding
D	0009165	biological_process	nucleotide biosynthetic process
D	0016787	molecular_function	hydrolase activity
D	0042802	molecular_function	identical protein binding
D	0043174	biological_process	nucleoside salvage
D	0046872	molecular_function	metal ion binding
D	0070694	molecular_function	5-hydroxymethyl-dUMP N-hydrolase activity
E	0003824	molecular_function	catalytic activity
E	0004132	molecular_function	dCMP deaminase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006220	biological_process	pyrimidine nucleotide metabolic process
E	0006226	biological_process	dUMP biosynthetic process
E	0006231	biological_process	dTMP biosynthetic process
E	0008270	molecular_function	zinc ion binding
E	0009165	biological_process	nucleotide biosynthetic process
E	0016787	molecular_function	hydrolase activity
E	0042802	molecular_function	identical protein binding
E	0043174	biological_process	nucleoside salvage
E	0046872	molecular_function	metal ion binding
E	0070694	molecular_function	5-hydroxymethyl-dUMP N-hydrolase activity
F	0003824	molecular_function	catalytic activity
F	0004132	molecular_function	dCMP deaminase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006220	biological_process	pyrimidine nucleotide metabolic process
F	0006226	biological_process	dUMP biosynthetic process
F	0006231	biological_process	dTMP biosynthetic process
F	0008270	molecular_function	zinc ion binding
F	0009165	biological_process	nucleotide biosynthetic process
F	0016787	molecular_function	hydrolase activity
F	0042802	molecular_function	identical protein binding
F	0043174	biological_process	nucleoside salvage
F	0046872	molecular_function	metal ion binding
F	0070694	molecular_function	5-hydroxymethyl-dUMP N-hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A1170

Chain	Residue
A	HIS84
A	CYS110
A	CYS113
A	HOH2049

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D1170

Chain	Residue
D	HIS84
D	CYS110
D	CYS113
D	HOH2036

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E1174

Chain	Residue
E	CYS110
E	CYS113
E	HOH2044
E	HIS84

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F1171

Chain	Residue
F	HIS84
F	CYS110
F	CYS113
F	HOH2051

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B1171

Chain	Residue
B	HIS84
B	CYS110
B	CYS113
B	HOH2035

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C1170

Chain	Residue
C	HIS84
C	CYS110
C	CYS113
C	HOH2037

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A1171

Chain	Residue
A	TYR132

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A1172

Chain	Residue
B	LYS74

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E1175

Chain	Residue
F	LYS74
F	LEU75

Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	34
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAElnAImnknltdvkgcsmyvalf...............PCne......CaklI

Chain	Residue	Details
A	HIS84-ILE117

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton donor => ECO:0000255\|PROSITE-ProRule:PRU01083

Chain	Residue	Details
A	GLU86
B	GLU86
C	GLU86
D	GLU86
E	GLU86
F	GLU86

site_id	SWS_FT_FI2
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269\|Ref.11, ECO:0007744\|PDB:2W4L

Chain	Residue	Details
A	HIS84
D	HIS84
D	CYS110
D	CYS113
E	HIS84
E	CYS110
E	CYS113
F	HIS84
F	CYS110
F	CYS113
A	CYS110
A	CYS113
B	HIS84
B	CYS110
B	CYS113
C	HIS84
C	CYS110
C	CYS113

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER174
B	SER174
C	SER174
D	SER174
E	SER174
F	SER174

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)