2W2L
Crystal structure of the holo forms of Rhodotorula graminis D- mandelate dehydrogenase at 2.5A.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| A | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| B | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| B | 0051287 | molecular_function | NAD binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| C | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| C | 0051287 | molecular_function | NAD binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| D | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NAD A 1347 |
| Chain | Residue |
| A | THR117 |
| A | THR234 |
| A | THR255 |
| A | ALA256 |
| A | ARG257 |
| A | ASP281 |
| A | HIS304 |
| A | GLY306 |
| A | GLY307 |
| A | HOH2076 |
| A | HOH2088 |
| A | LEU171 |
| A | GLY172 |
| A | ALA173 |
| A | ILE174 |
| A | ASP194 |
| A | VAL228 |
| A | PRO229 |
| A | MET231 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1348 |
| Chain | Residue |
| A | VAL60 |
| A | ALA89 |
| A | GLY90 |
| A | ARG257 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NAD B 1347 |
| Chain | Residue |
| B | THR117 |
| B | GLY172 |
| B | ALA173 |
| B | ILE174 |
| B | TYR193 |
| B | ASP194 |
| B | VAL195 |
| B | VAL228 |
| B | PRO229 |
| B | THR255 |
| B | ALA256 |
| B | ARG257 |
| B | ASP281 |
| B | HIS304 |
| B | GLY306 |
| B | GLY307 |
| B | HOH2024 |
| B | HOH2042 |
| B | HOH2058 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1348 |
| Chain | Residue |
| B | GLY88 |
| B | ALA89 |
| B | GLY90 |
| B | ARG257 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE NAD C 1346 |
| Chain | Residue |
| C | THR117 |
| C | GLY170 |
| C | GLY172 |
| C | ALA173 |
| C | ILE174 |
| C | TYR193 |
| C | ASP194 |
| C | VAL195 |
| C | VAL228 |
| C | PRO229 |
| C | THR234 |
| C | THR255 |
| C | ALA256 |
| C | HIS304 |
| C | GLY306 |
| C | GLY307 |
| C | SO41347 |
| C | HOH2095 |
| C | HOH2096 |
| C | HOH2131 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1347 |
| Chain | Residue |
| C | GLY88 |
| C | ALA89 |
| C | GLY90 |
| C | ARG257 |
| C | NAD1346 |
| site_id | AC7 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NAD D 1346 |
| Chain | Residue |
| C | HOH2012 |
| C | HOH2013 |
| D | THR117 |
| D | GLY172 |
| D | ALA173 |
| D | ILE174 |
| D | ASP194 |
| D | VAL195 |
| D | VAL228 |
| D | PRO229 |
| D | MET231 |
| D | THR234 |
| D | THR255 |
| D | ALA256 |
| D | ARG257 |
| D | ASP281 |
| D | HIS304 |
| D | GLY306 |
| D | GLY307 |
| D | SO41347 |
| D | HOH2035 |
| D | HOH2081 |
| D | HOH2082 |
| D | HOH2083 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1347 |
| Chain | Residue |
| D | NAD1346 |
| D | GLY88 |
| D | ALA89 |
| D | GLY90 |
| D | ARG257 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1gdh |
| Chain | Residue | Details |
| A | GLU286 | |
| A | PRO259 | |
| A | HIS304 | |
| A | ASP281 | |
| A | ARG257 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1gdh |
| Chain | Residue | Details |
| B | GLU286 | |
| B | PRO259 | |
| B | HIS304 | |
| B | ASP281 | |
| B | ARG257 |
| site_id | CSA3 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1gdh |
| Chain | Residue | Details |
| C | GLU286 | |
| C | PRO259 | |
| C | HIS304 | |
| C | ASP281 | |
| C | ARG257 |
| site_id | CSA4 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1gdh |
| Chain | Residue | Details |
| D | GLU286 | |
| D | PRO259 | |
| D | HIS304 | |
| D | ASP281 | |
| D | ARG257 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gdh |
| Chain | Residue | Details |
| A | GLU286 | |
| A | HIS304 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gdh |
| Chain | Residue | Details |
| B | GLU286 | |
| B | HIS304 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gdh |
| Chain | Residue | Details |
| C | GLU286 | |
| C | HIS304 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1gdh |
| Chain | Residue | Details |
| D | GLU286 | |
| D | HIS304 |
