Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2VZ9

Crystal Structure of Mammalian Fatty Acid Synthase in complex with NADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004312	molecular_function	fatty acid synthase activity
A	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
A	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0008610	biological_process	lipid biosynthetic process
A	0009058	biological_process	biosynthetic process
A	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
A	0031177	molecular_function	phosphopantetheine binding
A	0036094	molecular_function	small molecule binding
A	0046949	biological_process	fatty-acyl-CoA biosynthetic process
A	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004312	molecular_function	fatty acid synthase activity
B	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
B	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
B	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
B	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0008610	biological_process	lipid biosynthetic process
B	0009058	biological_process	biosynthetic process
B	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
B	0031177	molecular_function	phosphopantetheine binding
B	0036094	molecular_function	small molecule binding
B	0046949	biological_process	fatty-acyl-CoA biosynthetic process
B	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE NAP A3001

Chain	Residue
A	PHE1573
A	LYS1704
A	SER1723
A	ARG1724
A	ILE1769
A	ILE1794
A	LEU1796
A	MET1843
A	ALA1844
A	GLY1846
A	HIS1848
A	THR1654
A	SER1675
A	SER1677
A	GLY1678
A	GLY1679
A	VAL1680
A	VAL1699
A	GLY1700

site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE NAP A3002

Chain	Residue
A	GLY1891
A	GLY1894
A	PHE1896
A	THR1915
A	SER1916
A	ARG1917
A	SER1918
A	ARG1921
A	ASN1945
A	LEU1971
A	ALA1972
A	MET1973
A	LYS1995
A	PHE2019
A	SER2020
A	SER2021
A	TYR2034
A	GLY2061
A	ILE2063
A	GLY2067
A	VAL2068
A	VAL2069

site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR RESIDUE NAP B3001

Chain	Residue
B	PHE1573
B	THR1654
B	SER1675
B	SER1677
B	GLY1678
B	GLY1679
B	VAL1680
B	VAL1699
B	GLY1700
B	LYS1704
B	SER1723
B	ARG1724
B	ILE1769
B	LYS1771
B	ILE1794
B	LEU1796
B	ALA1844
B	GLY1846
B	HIS1848

site_id	AC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE NAP B3002

Chain	Residue
B	GLY1894
B	PHE1896
B	THR1915
B	SER1916
B	ARG1917
B	SER1918
B	ASN1945
B	LEU1971
B	ALA1972
B	MET1973
B	LYS1995
B	PHE2019
B	SER2020
B	SER2021
B	TYR2034
B	GLY2061
B	ILE2063
B	GLY2067
B	VAL2068
B	VAL2069

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLMGVEVRQIL

Chain	Residue	Details
A	ASP2152-LEU2167

site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPSitIDtACSSSllAL

Chain	Residue	Details
A	GLY152-LEU168

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1kas

Chain	Residue	Details
A	PHE395
A	HIS331
A	CYS161
A	HIS293

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1kas

Chain	Residue	Details
B	PHE395
B	HIS331
B	CYS161
B	HIS293

site_id	CSA3
Number of Residues	6
Details	Annotated By Reference To The Literature 1kas

Chain	Residue	Details
A	PHE395
A	LYS326
A	CYS161
A	HIS331
A	HIS293
A	PHE393

site_id	CSA4
Number of Residues	6
Details	Annotated By Reference To The Literature 1kas

Chain	Residue	Details
B	PHE395
B	LYS326
B	CYS161
B	HIS331
B	HIS293
B	PHE393

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1kas

Chain	Residue	Details
A	LEU1583

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1kas

Chain	Residue	Details
B	LEU1583

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1kas

Chain	Residue	Details
A	TYR2034
A	ASN2038

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1kas

Chain	Residue	Details
B	TYR2034
B	ASN2038

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)