2VZ9
Crystal Structure of Mammalian Fatty Acid Synthase in complex with NADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004312 | molecular_function | fatty acid synthase activity |
| A | 0004313 | molecular_function | [acyl-carrier-protein] S-acetyltransferase activity |
| A | 0004314 | molecular_function | [acyl-carrier-protein] S-malonyltransferase activity |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005835 | cellular_component | fatty acid synthase complex |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0008610 | biological_process | lipid biosynthetic process |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0016297 | molecular_function | fatty acyl-[ACP] hydrolase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| A | 0031177 | molecular_function | phosphopantetheine binding |
| A | 0036094 | molecular_function | small molecule binding |
| A | 0046949 | biological_process | fatty-acyl-CoA biosynthetic process |
| A | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 0004312 | molecular_function | fatty acid synthase activity |
| B | 0004313 | molecular_function | [acyl-carrier-protein] S-acetyltransferase activity |
| B | 0004314 | molecular_function | [acyl-carrier-protein] S-malonyltransferase activity |
| B | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| B | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0005835 | cellular_component | fatty acid synthase complex |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0008610 | biological_process | lipid biosynthetic process |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0016297 | molecular_function | fatty acyl-[ACP] hydrolase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| B | 0031177 | molecular_function | phosphopantetheine binding |
| B | 0036094 | molecular_function | small molecule binding |
| B | 0046949 | biological_process | fatty-acyl-CoA biosynthetic process |
| B | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NAP A3001 |
| Chain | Residue |
| A | PHE1573 |
| A | LYS1704 |
| A | SER1723 |
| A | ARG1724 |
| A | ILE1769 |
| A | ILE1794 |
| A | LEU1796 |
| A | MET1843 |
| A | ALA1844 |
| A | GLY1846 |
| A | HIS1848 |
| A | THR1654 |
| A | SER1675 |
| A | SER1677 |
| A | GLY1678 |
| A | GLY1679 |
| A | VAL1680 |
| A | VAL1699 |
| A | GLY1700 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE NAP A3002 |
| Chain | Residue |
| A | GLY1891 |
| A | GLY1894 |
| A | PHE1896 |
| A | THR1915 |
| A | SER1916 |
| A | ARG1917 |
| A | SER1918 |
| A | ARG1921 |
| A | ASN1945 |
| A | LEU1971 |
| A | ALA1972 |
| A | MET1973 |
| A | LYS1995 |
| A | PHE2019 |
| A | SER2020 |
| A | SER2021 |
| A | TYR2034 |
| A | GLY2061 |
| A | ILE2063 |
| A | GLY2067 |
| A | VAL2068 |
| A | VAL2069 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NAP B3001 |
| Chain | Residue |
| B | PHE1573 |
| B | THR1654 |
| B | SER1675 |
| B | SER1677 |
| B | GLY1678 |
| B | GLY1679 |
| B | VAL1680 |
| B | VAL1699 |
| B | GLY1700 |
| B | LYS1704 |
| B | SER1723 |
| B | ARG1724 |
| B | ILE1769 |
| B | LYS1771 |
| B | ILE1794 |
| B | LEU1796 |
| B | ALA1844 |
| B | GLY1846 |
| B | HIS1848 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE NAP B3002 |
| Chain | Residue |
| B | GLY1894 |
| B | PHE1896 |
| B | THR1915 |
| B | SER1916 |
| B | ARG1917 |
| B | SER1918 |
| B | ASN1945 |
| B | LEU1971 |
| B | ALA1972 |
| B | MET1973 |
| B | LYS1995 |
| B | PHE2019 |
| B | SER2020 |
| B | SER2021 |
| B | TYR2034 |
| B | GLY2061 |
| B | ILE2063 |
| B | GLY2067 |
| B | VAL2068 |
| B | VAL2069 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| A | PHE395 | |
| A | HIS331 | |
| A | CYS161 | |
| A | HIS293 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| B | PHE395 | |
| B | HIS331 | |
| B | CYS161 | |
| B | HIS293 |
| site_id | CSA3 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| A | PHE395 | |
| A | LYS326 | |
| A | CYS161 | |
| A | HIS331 | |
| A | HIS293 | |
| A | PHE393 |
| site_id | CSA4 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| B | PHE395 | |
| B | LYS326 | |
| B | CYS161 | |
| B | HIS331 | |
| B | HIS293 | |
| B | PHE393 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| A | LEU1583 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| B | LEU1583 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| A | TYR2034 | |
| A | ASN2038 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kas |
| Chain | Residue | Details |
| B | TYR2034 | |
| B | ASN2038 |
