2VXO
Human GMP synthetase in complex with XMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003921 | molecular_function | GMP synthase activity |
| A | 0003922 | molecular_function | GMP synthase (glutamine-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006541 | biological_process | glutamine metabolic process |
| A | 0009113 | biological_process | purine nucleobase biosynthetic process |
| A | 0009168 | biological_process | purine ribonucleoside monophosphate biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046037 | biological_process | GMP metabolic process |
| B | 0003921 | molecular_function | GMP synthase activity |
| B | 0003922 | molecular_function | GMP synthase (glutamine-hydrolyzing) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006177 | biological_process | GMP biosynthetic process |
| B | 0006541 | biological_process | glutamine metabolic process |
| B | 0009113 | biological_process | purine nucleobase biosynthetic process |
| B | 0009168 | biological_process | purine ribonucleoside monophosphate biosynthetic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0046037 | biological_process | GMP metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE XMP A 1694 |
| Chain | Residue |
| A | ARG337 |
| A | THR689 |
| A | THR690 |
| A | GLU691 |
| A | HOH2066 |
| A | HOH2067 |
| B | ASP522 |
| A | GLY383 |
| A | LYS384 |
| A | PRO439 |
| A | GLY440 |
| A | PRO441 |
| A | GLN610 |
| A | PHE645 |
| A | LYS685 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE XMP B 1694 |
| Chain | Residue |
| A | ASP522 |
| B | ARG337 |
| B | GLY383 |
| B | LYS384 |
| B | PRO439 |
| B | GLY440 |
| B | PRO441 |
| B | ARG524 |
| B | GLN610 |
| B | PHE645 |
| B | LYS685 |
| B | THR689 |
| B | THR690 |
| B | GLU691 |
| B | HOH2029 |
| B | HOH2057 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1695 |
| Chain | Residue |
| A | ARG276 |
| A | GLU279 |
| A | ARG435 |
| A | HIS436 |
| A | HIS596 |
| A | ARG600 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1696 |
| Chain | Residue |
| A | THR581 |
| A | GLY583 |
| A | VAL584 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1695 |
| Chain | Residue |
| B | THR581 |
| B | GLY583 |
| B | VAL584 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1696 |
| Chain | Residue |
| B | ARG276 |
| B | ARG435 |
| B | HIS436 |
| B | HIS596 |
| B | ARG600 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1697 |
| Chain | Residue |
| A | SER244 |
| A | GLY246 |
| A | VAL247 |
| A | ASP248 |
| A | SER249 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1697 |
| Chain | Residue |
| B | SER244 |
| B | GLY246 |
| B | ASP248 |
| B | SER249 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: For GATase activity => ECO:0000255|PROSITE-ProRule:PRU00605, ECO:0000269|PubMed:23816837 |
| Chain | Residue | Details |
| A | GLU192 | |
| B | CYS104 | |
| B | HIS190 | |
| B | GLU192 | |
| A | CYS104 | |
| A | HIS190 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00886 |
| Chain | Residue | Details |
| A | SER244 | |
| B | SER244 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23816837 |
| Chain | Residue | Details |
| A | ARG337 | |
| A | ASP522 | |
| A | GLN610 | |
| A | LYS685 | |
| A | GLU691 | |
| B | ARG337 | |
| B | ASP522 | |
| B | GLN610 | |
| B | LYS685 | |
| B | GLU691 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | THR318 | |
| B | THR318 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER332 | |
| B | SER332 |
