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2VW0

Crystal structure of the NanB sialidase from Streptococcus pneumoniae

Functional Information from GO Data
ChainGOidnamespacecontents
A0004308molecular_functionexo-alpha-sialidase activity
A0005975biological_processcarbohydrate metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A1697
ChainResidue
ASER253
ALYS315
AHOH2424

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A1698
ChainResidue
AHOH2426
ATYR250
ATHR251
AGLN494
AILE596
ATHR657
AHOH2425

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000250
ChainResidueDetails
AASP270

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000255
ChainResidueDetails
AGLU541

site_idSWS_FT_FI3
Number of Residues1
DetailsACT_SITE: Nucleophile => ECO:0000250
ChainResidueDetails
ATYR653

site_idSWS_FT_FI4
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AARG245
AARG557
AARG619

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1sll
ChainResidueDetails
ATYR653
AGLU541
AASP270

226707

PDB entries from 2024-10-30

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