Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2VVQ

Crystal structure of Mycobacterium tuberculosis ribose-5-phosphate isomerase B in complex with the inhibitor 5-deoxy-5-phospho-D- ribonate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004751	molecular_function	ribose-5-phosphate isomerase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005975	biological_process	carbohydrate metabolic process
A	0006098	biological_process	pentose-phosphate shunt
A	0009052	biological_process	pentose-phosphate shunt, non-oxidative branch
A	0016853	molecular_function	isomerase activity
A	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
A	0019316	biological_process	D-allose catabolic process
B	0004751	molecular_function	ribose-5-phosphate isomerase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005975	biological_process	carbohydrate metabolic process
B	0006098	biological_process	pentose-phosphate shunt
B	0009052	biological_process	pentose-phosphate shunt, non-oxidative branch
B	0016853	molecular_function	isomerase activity
B	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
B	0019316	biological_process	D-allose catabolic process
C	0004751	molecular_function	ribose-5-phosphate isomerase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005975	biological_process	carbohydrate metabolic process
C	0006098	biological_process	pentose-phosphate shunt
C	0009052	biological_process	pentose-phosphate shunt, non-oxidative branch
C	0016853	molecular_function	isomerase activity
C	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
C	0019316	biological_process	D-allose catabolic process
D	0004751	molecular_function	ribose-5-phosphate isomerase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005975	biological_process	carbohydrate metabolic process
D	0006098	biological_process	pentose-phosphate shunt
D	0009052	biological_process	pentose-phosphate shunt, non-oxidative branch
D	0016853	molecular_function	isomerase activity
D	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
D	0019316	biological_process	D-allose catabolic process
E	0004751	molecular_function	ribose-5-phosphate isomerase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005975	biological_process	carbohydrate metabolic process
E	0006098	biological_process	pentose-phosphate shunt
E	0009052	biological_process	pentose-phosphate shunt, non-oxidative branch
E	0016853	molecular_function	isomerase activity
E	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
E	0019316	biological_process	D-allose catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE R10 A 200

Chain	Residue
A	ASP11
A	GLU75
A	ARG113
A	HOH2033
A	HOH2107
A	HOH2108
A	HOH2109
B	HIS102
B	ASN103
B	ARG137
B	ARG141
A	HIS12
C	HOH2084
A	TYR46
A	GLY69
A	GLY70
A	SER71
A	GLY72
A	ASN73
A	GLY74

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 300

Chain	Residue
A	HOH2110
A	HOH2111
A	HOH2112
B	HIS152
D	ARG5
D	HOH2046

site_id	AC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE R10 B 200

Chain	Residue
A	HIS102
A	ASN103
A	ARG137
A	ARG141
A	HOH2084
B	ASP11
B	HIS12
B	TYR46
B	GLY69
B	GLY70
B	SER71
B	GLY72
B	ASN73
B	GLY74
B	GLU75
B	ARG113
B	HOH2028
B	HOH2113
B	HOH2114
B	HOH2115

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE R10 C 200

Chain	Residue
C	ASP11
C	HIS12
C	TYR46
C	GLY69
C	GLY70
C	SER71
C	GLY72
C	ASN73
C	GLY74
C	GLU75
C	ARG113
C	HOH2028
C	HOH2113
C	HOH2114
C	HOH2115
D	HIS102
D	ARG137
D	ARG141
D	HOH2098

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 300

Chain	Residue
B	ARG5
C	HOH2116
D	HIS152
D	HOH2116

site_id	AC6
Number of Residues	19
Details	BINDING SITE FOR RESIDUE R10 D 200

Chain	Residue
C	HIS102
C	ASN103
C	ARG137
C	ARG141
C	HOH2087
D	ASP11
D	HIS12
D	TYR46
D	GLY69
D	GLY70
D	SER71
D	GLY72
D	ASN73
D	GLY74
D	GLU75
D	ARG113
D	HOH2027
D	HOH2121
D	HOH2122

site_id	AC7
Number of Residues	19
Details	BINDING SITE FOR RESIDUE R10 E 200

Chain	Residue
E	ASN103
E	ARG113
E	ARG137
E	ARG141
E	HOH2019
E	HOH2070
E	HOH2084
E	HOH2085
E	ASP11
E	HIS12
E	TYR46
E	GLY69
E	GLY70
E	SER71
E	GLY72
E	ASN73
E	GLY74
E	GLU75
E	HIS102

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"15590681","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18640127","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2BES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	5
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"15590681","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18640127","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2BES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14687575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15590681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18640127","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1USL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15590681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18640127","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15590681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18640127","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14687575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18640127","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1USL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)