Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2VUS

Crystal structure of unliganded NmrA-AreA zinc finger complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001081	biological_process	nitrogen catabolite repression of transcription from RNA polymerase II promoter
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006808	biological_process	regulation of nitrogen utilization
A	0016491	molecular_function	oxidoreductase activity
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0051287	molecular_function	NAD binding
A	0070401	molecular_function	NADP+ binding
A	0070402	molecular_function	NADPH binding
A	0070403	molecular_function	NAD+ binding
A	0070404	molecular_function	NADH binding
A	0070405	molecular_function	ammonium ion binding
A	0070406	molecular_function	glutamine binding
A	0090295	biological_process	nitrogen catabolite repression of transcription
B	0001081	biological_process	nitrogen catabolite repression of transcription from RNA polymerase II promoter
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006808	biological_process	regulation of nitrogen utilization
B	0016491	molecular_function	oxidoreductase activity
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0051287	molecular_function	NAD binding
B	0070401	molecular_function	NADP+ binding
B	0070402	molecular_function	NADPH binding
B	0070403	molecular_function	NAD+ binding
B	0070404	molecular_function	NADH binding
B	0070405	molecular_function	ammonium ion binding
B	0070406	molecular_function	glutamine binding
B	0090295	biological_process	nitrogen catabolite repression of transcription
C	0001081	biological_process	nitrogen catabolite repression of transcription from RNA polymerase II promoter
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006808	biological_process	regulation of nitrogen utilization
C	0016491	molecular_function	oxidoreductase activity
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0051287	molecular_function	NAD binding
C	0070401	molecular_function	NADP+ binding
C	0070402	molecular_function	NADPH binding
C	0070403	molecular_function	NAD+ binding
C	0070404	molecular_function	NADH binding
C	0070405	molecular_function	ammonium ion binding
C	0070406	molecular_function	glutamine binding
C	0090295	biological_process	nitrogen catabolite repression of transcription
D	0001081	biological_process	nitrogen catabolite repression of transcription from RNA polymerase II promoter
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006808	biological_process	regulation of nitrogen utilization
D	0016491	molecular_function	oxidoreductase activity
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0051287	molecular_function	NAD binding
D	0070401	molecular_function	NADP+ binding
D	0070402	molecular_function	NADPH binding
D	0070403	molecular_function	NAD+ binding
D	0070404	molecular_function	NADH binding
D	0070405	molecular_function	ammonium ion binding
D	0070406	molecular_function	glutamine binding
D	0090295	biological_process	nitrogen catabolite repression of transcription
E	0001081	biological_process	nitrogen catabolite repression of transcription from RNA polymerase II promoter
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0006808	biological_process	regulation of nitrogen utilization
E	0016491	molecular_function	oxidoreductase activity
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0051287	molecular_function	NAD binding
E	0070401	molecular_function	NADP+ binding
E	0070402	molecular_function	NADPH binding
E	0070403	molecular_function	NAD+ binding
E	0070404	molecular_function	NADH binding
E	0070405	molecular_function	ammonium ion binding
E	0070406	molecular_function	glutamine binding
E	0090295	biological_process	nitrogen catabolite repression of transcription
F	0001081	biological_process	nitrogen catabolite repression of transcription from RNA polymerase II promoter
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0006808	biological_process	regulation of nitrogen utilization
F	0016491	molecular_function	oxidoreductase activity
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0051287	molecular_function	NAD binding
F	0070401	molecular_function	NADP+ binding
F	0070402	molecular_function	NADPH binding
F	0070403	molecular_function	NAD+ binding
F	0070404	molecular_function	NADH binding
F	0070405	molecular_function	ammonium ion binding
F	0070406	molecular_function	glutamine binding
F	0090295	biological_process	nitrogen catabolite repression of transcription
G	0001081	biological_process	nitrogen catabolite repression of transcription from RNA polymerase II promoter
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0006808	biological_process	regulation of nitrogen utilization
G	0016491	molecular_function	oxidoreductase activity
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0051287	molecular_function	NAD binding
G	0070401	molecular_function	NADP+ binding
G	0070402	molecular_function	NADPH binding
G	0070403	molecular_function	NAD+ binding
G	0070404	molecular_function	NADH binding
G	0070405	molecular_function	ammonium ion binding
G	0070406	molecular_function	glutamine binding
G	0090295	biological_process	nitrogen catabolite repression of transcription
H	0001081	biological_process	nitrogen catabolite repression of transcription from RNA polymerase II promoter
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0006808	biological_process	regulation of nitrogen utilization
H	0016491	molecular_function	oxidoreductase activity
H	0045892	biological_process	negative regulation of DNA-templated transcription
H	0051287	molecular_function	NAD binding
H	0070401	molecular_function	NADP+ binding
H	0070402	molecular_function	NADPH binding
H	0070403	molecular_function	NAD+ binding
H	0070404	molecular_function	NADH binding
H	0070405	molecular_function	ammonium ion binding
H	0070406	molecular_function	glutamine binding
H	0090295	biological_process	nitrogen catabolite repression of transcription
I	0003700	molecular_function	DNA-binding transcription factor activity
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0008270	molecular_function	zinc ion binding
I	0043565	molecular_function	sequence-specific DNA binding
J	0003700	molecular_function	DNA-binding transcription factor activity
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0008270	molecular_function	zinc ion binding
J	0043565	molecular_function	sequence-specific DNA binding
K	0003700	molecular_function	DNA-binding transcription factor activity
K	0006355	biological_process	regulation of DNA-templated transcription
K	0006357	biological_process	regulation of transcription by RNA polymerase II
K	0008270	molecular_function	zinc ion binding
K	0043565	molecular_function	sequence-specific DNA binding
L	0003700	molecular_function	DNA-binding transcription factor activity
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0008270	molecular_function	zinc ion binding
L	0043565	molecular_function	sequence-specific DNA binding
M	0003700	molecular_function	DNA-binding transcription factor activity
M	0006355	biological_process	regulation of DNA-templated transcription
M	0006357	biological_process	regulation of transcription by RNA polymerase II
M	0008270	molecular_function	zinc ion binding
M	0043565	molecular_function	sequence-specific DNA binding
N	0003700	molecular_function	DNA-binding transcription factor activity
N	0006355	biological_process	regulation of DNA-templated transcription
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0008270	molecular_function	zinc ion binding
N	0043565	molecular_function	sequence-specific DNA binding
O	0003700	molecular_function	DNA-binding transcription factor activity
O	0006355	biological_process	regulation of DNA-templated transcription
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0008270	molecular_function	zinc ion binding
O	0043565	molecular_function	sequence-specific DNA binding
P	0003700	molecular_function	DNA-binding transcription factor activity
P	0006355	biological_process	regulation of DNA-templated transcription
P	0006357	biological_process	regulation of transcription by RNA polymerase II
P	0008270	molecular_function	zinc ion binding
P	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A1353

Chain	Residue
A	ARG16
A	TYR153
A	HOH2147

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B1353

Chain	Residue
B	GLY15
B	ARG16
B	TYR153
B	HOH2013
B	HOH2181

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C1353

Chain	Residue
C	ARG16
C	GLN17
C	TYR153
C	HOH2190
C	HOH2191
C	GLY15

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D1353

Chain	Residue
D	GLY15
D	ARG16
D	TYR153
D	HOH2019

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E1353

Chain	Residue
E	GLY15
E	ARG16
E	TYR153
E	HOH2070
E	HOH2206

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F1353

Chain	Residue
F	GLY15
F	ARG16
F	TYR153
F	HOH2089

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 G1353

Chain	Residue
G	ARG16
G	TYR153
G	HOH2108

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 H1353

Chain	Residue
H	GLY15
H	ARG16
H	TYR153
H	HOH2176
H	HOH2177

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A1354

Chain	Residue
A	ASN12
A	ALA13
A	THR14
A	HIS37

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C1354

Chain	Residue
C	THR14
C	HIS37

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL F1354

Chain	Residue
F	ASN12
F	ALA13
F	THR14
F	VAL36
F	HIS37

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL G1354

Chain	Residue
G	ASN12
G	ALA13
G	THR14
G	HIS37

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL G1355

Chain	Residue
A	HIS214
G	HIS214
G	ARG215
G	HOH2147

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL H1354

Chain	Residue
H	ASN12
H	THR14
H	HIS37

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D1354

Chain	Residue
D	ASN12
D	ALA13
D	THR14
D	HIS37

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN I1713

Chain	Residue
I	CYS673
I	CYS676
I	CYS694
I	CYS697
I	ARG708

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J1713

Chain	Residue
J	CYS673
J	CYS676
J	CYS694
J	CYS697

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K1712

Chain	Residue
K	CYS673
K	CYS676
K	CYS694
K	CYS697

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L1713

Chain	Residue
L	CYS673
L	CYS676
L	CYS694
L	CYS697

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN M1713

Chain	Residue
M	CYS673
M	CYS676
M	CYS694
M	CYS697

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN N1713

Chain	Residue
N	CYS673
N	CYS676
N	CYS694
N	CYS697

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN O1712

Chain	Residue
O	CYS673
O	CYS676
O	CYS694
O	CYS697

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P1713

Chain	Residue
P	CYS673
P	CYS676
P	CYS694
P	CYS697

Functional Information from PROSITE/UniProt

site_id	PS00344
Number of Residues	25
Details	GATA_ZN_FINGER_1 GATA-type zinc finger domain. CtNCftqt..TplWRRnpe.Gqpl...CNAC

Chain	Residue	Details
I	CYS673-CYS697

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12764138","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TI7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11726498","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1K6X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	192
Details	Zinc finger: {"description":"GATA-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00094","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)