2VUB

CCDB, A TOPOISOMERASE POISON FROM E. COLI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0006276	biological_process	plasmid maintenance
A	0008657	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
A	0017053	cellular_component	transcription repressor complex
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0110001	cellular_component	toxin-antitoxin complex
A	2000104	biological_process	negative regulation of DNA-templated DNA replication
B	0005515	molecular_function	protein binding
B	0006276	biological_process	plasmid maintenance
B	0008657	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
B	0017053	cellular_component	transcription repressor complex
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0110001	cellular_component	toxin-antitoxin complex
B	2000104	biological_process	negative regulation of DNA-templated DNA replication
C	0005515	molecular_function	protein binding
C	0006276	biological_process	plasmid maintenance
C	0008657	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
C	0017053	cellular_component	transcription repressor complex
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0110001	cellular_component	toxin-antitoxin complex
C	2000104	biological_process	negative regulation of DNA-templated DNA replication
D	0005515	molecular_function	protein binding
D	0006276	biological_process	plasmid maintenance
D	0008657	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
D	0017053	cellular_component	transcription repressor complex
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0110001	cellular_component	toxin-antitoxin complex
D	2000104	biological_process	negative regulation of DNA-templated DNA replication
E	0005515	molecular_function	protein binding
E	0006276	biological_process	plasmid maintenance
E	0008657	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
E	0017053	cellular_component	transcription repressor complex
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0110001	cellular_component	toxin-antitoxin complex
E	2000104	biological_process	negative regulation of DNA-templated DNA replication
F	0005515	molecular_function	protein binding
F	0006276	biological_process	plasmid maintenance
F	0008657	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
F	0017053	cellular_component	transcription repressor complex
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0110001	cellular_component	toxin-antitoxin complex
F	2000104	biological_process	negative regulation of DNA-templated DNA replication
G	0005515	molecular_function	protein binding
G	0006276	biological_process	plasmid maintenance
G	0008657	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
G	0017053	cellular_component	transcription repressor complex
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0110001	cellular_component	toxin-antitoxin complex
G	2000104	biological_process	negative regulation of DNA-templated DNA replication
H	0005515	molecular_function	protein binding
H	0006276	biological_process	plasmid maintenance
H	0008657	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
H	0017053	cellular_component	transcription repressor complex
H	0045892	biological_process	negative regulation of DNA-templated transcription
H	0110001	cellular_component	toxin-antitoxin complex
H	2000104	biological_process	negative regulation of DNA-templated DNA replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 102

Chain	Residue
D	HIS55
D	ARG86
F	HIS85
F	HOH117

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 102

Chain	Residue
C	HIS55
C	HIS85
C	ARG86

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 102

Chain	Residue
E	HIS55
E	ARG86

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 102

Chain	Residue
B	HIS85
B	ARG86

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site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL F 102

Chain	Residue
A	ARG30
F	ARG30

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