2VRR
Structure of SUMO modified Ubc9
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001221 | molecular_function | transcription coregulator binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005643 | cellular_component | nuclear pore |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0007059 | biological_process | chromosome segregation |
| A | 0016604 | cellular_component | nuclear body |
| A | 0016605 | cellular_component | PML body |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016925 | biological_process | protein sumoylation |
| A | 0019789 | molecular_function | SUMO transferase activity |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0030335 | biological_process | positive regulation of cell migration |
| A | 0036211 | biological_process | protein modification process |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0043398 | molecular_function | HLH domain binding |
| A | 0044388 | molecular_function | small protein activating enzyme binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0050804 | biological_process | modulation of chemical synaptic transmission |
| A | 0051168 | biological_process | nuclear export |
| A | 0051301 | biological_process | cell division |
| A | 0061656 | molecular_function | SUMO conjugating enzyme activity |
| A | 0071535 | molecular_function | RING-like zinc finger domain binding |
| A | 0098685 | cellular_component | Schaffer collateral - CA1 synapse |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0099523 | cellular_component | presynaptic cytosol |
| A | 0099524 | cellular_component | postsynaptic cytosol |
| A | 0106068 | cellular_component | SUMO ligase complex |
| A | 1990234 | cellular_component | transferase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE FMT B1098 |
| Chain | Residue |
| B | ARG70 |
| B | GLU93 |
| B | FMT1099 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT B1099 |
| Chain | Residue |
| B | GLU33 |
| B | FMT1098 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT A1159 |
| Chain | Residue |
| A | ALA15 |
| A | HOH2012 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT A1160 |
| Chain | Residue |
| A | LYS59 |
| A | PHE155 |
| A | HOH2136 |
| A | LEU57 |
| A | PHE58 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA A1161 |
| Chain | Residue |
| A | GLU99 |
| A | ALA106 |
Functional Information from PROSITE/UniProt
| site_id | PS00183 |
| Number of Residues | 16 |
| Details | UBC_1 Ubiquitin-conjugating (UBC) active site signature. FHPNVyps.GtVCLsiL |
| Chain | Residue | Details |
| A | PHE82-LEU97 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | SITE: Interaction with PIAS2 |
| Chain | Residue | Details |
| B | PHE36 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER32 | |
| A | VAL25 | |
| A | LEU57 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS23 | |
| B | LYS39 | |
| B | LYS45 | |
| B | LYS46 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000269|PubMed:27068747 |
| Chain | Residue | Details |
| A | SER2 | |
| B | GLY97 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) |
| Chain | Residue | Details |
| B | LYS25 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS37 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P63279 |
| Chain | Residue | Details |
| A | LYS18 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:P63279 |
| Chain | Residue | Details |
| A | LYS48 | |
| A | LYS101 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P63279 |
| Chain | Residue | Details |
| A | LYS49 |
