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2VQO

Structure of HDAC4 catalytic domain with a gain-of-function muation bound to a trifluoromethylketone inhbitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000118cellular_componenthistone deacetylase complex
A0004407molecular_functionhistone deacetylase activity
A0006325biological_processchromatin organization
A0016575biological_processhistone deacetylation
B0000118cellular_componenthistone deacetylase complex
B0004407molecular_functionhistone deacetylase activity
B0006325biological_processchromatin organization
B0016575biological_processhistone deacetylation
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A1406
ChainResidue
ALYS20
AARG37
AILE38
AARG154
AHOH2122

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A1407
ChainResidue
ATRP42
AGLN46
AARG51
AHOH2123

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K A1408
ChainResidue
AASP194
AASP196
AHIS198
ASER217
ALEU218

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K A1409
ChainResidue
APHE207
AASP210
AVAL213
APHE244
AHOH2069
AHOH2070

site_idAC5
Number of Residues19
DetailsBINDING SITE FOR RESIDUE TFG A1410
ChainResidue
APRO156
AHIS158
AHIS159
AGLY167
APHE168
AASP196
AHIS198
APHE227
AASP290
AGLU329
AGLY330
AZN1411
AHOH2087
AHOH2124
AHOH2125
BLEU78
BTYR79
BTHR81
BALA124

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A1411
ChainResidue
AASP196
AHIS198
AASP290
ATFG1410

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B1406
ChainResidue
BLYS20
BARG37
BILE38
BARG154
BHOH2126

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K B1407
ChainResidue
BASP194
BASP196
BHIS198
BSER217
BLEU218

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K B1408
ChainResidue
BPHE207
BASP210
BVAL213
BPHE244
BHOH2068

site_idBC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE TFG B1409
ChainResidue
ALEU78
ATYR79
ATHR81
AVAL121
AALA124
BPRO156
BHIS158
BHIS159
BGLY167
BPHE168
BASP196
BHIS198
BPHE227
BASP290
BLEU299
BGLY330
BZN1410
BHOH2092
BHOH2127

site_idBC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B1410
ChainResidue
BASP196
BHIS198
BASP290
BTFG1409

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
AHIS159
BHIS159

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ACYS23
AALA25
AHIS31
ACYS107
BCYS23
BALA25
BHIS31
BCYS107

218853

PDB entries from 2024-04-24

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