2VPE

Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003713	molecular_function	transcription coactivator activity
B	0008013	molecular_function	beta-catenin binding
B	0060070	biological_process	canonical Wnt signaling pathway
D	0003713	molecular_function	transcription coactivator activity
D	0008013	molecular_function	beta-catenin binding
D	0060070	biological_process	canonical Wnt signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A1399

Chain	Residue
A	GLN354
A	HIS368
A	HOH2076
A	HOH2077
A	HOH2078
C	GLY336
C	ASN348

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C1398

Chain	Residue
C	HIS368
C	CYS371
C	CYS343
C	CYS346

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C1399

Chain	Residue
C	CYS359
C	CYS363
C	CYS392
C	CYS395

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A1400

Chain	Residue
A	CYS343
A	CYS346
A	HIS368
A	CYS371

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A1401

Chain	Residue
A	CYS359
A	CYS363
A	CYS392
A	CYS395

---

Functional Information from PROSITE/UniProt

site_id	PS01359
Number of Residues	53
Details	ZF_PHD_1 Zinc finger PHD-type signature. CgiCtnevnddqda...................................IlCeas.Cqkw.FHriCtgmtetayglltaeasav...........................WgCdtC

Chain	Residue	Details
A	CYS343-CYS395

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	58
Details	Zinc finger: {"description":"PHD-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00146","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	94
Details	Region: {"description":"Interaction with H3K4me2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Region: {"description":"Interaction with BCL9","evidences":[{"source":"PubMed","id":"18498752","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---