2VP5
Structural Studies of Nucleoside Analog and Feedback Inhibitor Binding to Drosophila Melanogaster Multisubstrate Deoxyribonucleoside Kinase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004136 | molecular_function | deoxyadenosine kinase activity |
| A | 0004137 | molecular_function | deoxycytidine kinase activity |
| A | 0004138 | molecular_function | deoxyguanosine kinase activity |
| A | 0004797 | molecular_function | thymidine kinase activity |
| A | 0004849 | molecular_function | uridine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006170 | biological_process | dAMP biosynthetic process |
| A | 0006222 | biological_process | UMP biosynthetic process |
| A | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| A | 0009224 | biological_process | CMP biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0019136 | molecular_function | deoxynucleoside kinase activity |
| A | 0043174 | biological_process | nucleoside salvage |
| A | 0043771 | molecular_function | cytidine kinase activity |
| A | 0071897 | biological_process | DNA biosynthetic process |
| A | 1901293 | biological_process | nucleoside phosphate biosynthetic process |
| B | 0004136 | molecular_function | deoxyadenosine kinase activity |
| B | 0004137 | molecular_function | deoxycytidine kinase activity |
| B | 0004138 | molecular_function | deoxyguanosine kinase activity |
| B | 0004797 | molecular_function | thymidine kinase activity |
| B | 0004849 | molecular_function | uridine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0006170 | biological_process | dAMP biosynthetic process |
| B | 0006222 | biological_process | UMP biosynthetic process |
| B | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| B | 0009224 | biological_process | CMP biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016310 | biological_process | phosphorylation |
| B | 0019136 | molecular_function | deoxynucleoside kinase activity |
| B | 0043174 | biological_process | nucleoside salvage |
| B | 0043771 | molecular_function | cytidine kinase activity |
| B | 0071897 | biological_process | DNA biosynthetic process |
| B | 1901293 | biological_process | nucleoside phosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A1209 |
| Chain | Residue |
| A | GLY30 |
| A | SER31 |
| A | GLY32 |
| A | LYS33 |
| A | THR34 |
| A | ARG167 |
| A | HOH2023 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B1209 |
| Chain | Residue |
| B | SER31 |
| B | GLY32 |
| B | LYS33 |
| B | THR34 |
| B | ARG167 |
| B | HOH2064 |
| B | HOH2065 |
| B | ASN28 |
| B | GLY30 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE DCZ A1210 |
| Chain | Residue |
| A | ILE29 |
| A | GLU52 |
| A | TRP57 |
| A | LEU66 |
| A | MET69 |
| A | TYR70 |
| A | PHE80 |
| A | GLN81 |
| A | VAL84 |
| A | ARG105 |
| A | ALA110 |
| A | PHE114 |
| A | GLU172 |
| A | HOH2011 |
| A | HOH2054 |
| A | HOH2055 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE DCZ B1210 |
| Chain | Residue |
| B | ILE29 |
| B | GLU52 |
| B | TRP57 |
| B | LEU66 |
| B | MET69 |
| B | TYR70 |
| B | PHE80 |
| B | GLN81 |
| B | VAL84 |
| B | ARG105 |
| B | ALA110 |
| B | PHE114 |
| B | ARG169 |
| B | GLU172 |
| B | HOH2017 |
| B | HOH2029 |
| B | HOH2055 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU104 | |
| B | GLU104 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY27 | |
| B | GLY27 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLU52 | |
| B | GLU172 | |
| A | TYR70 | |
| A | GLN81 | |
| A | ARG105 | |
| A | GLU172 | |
| B | GLU52 | |
| B | TYR70 | |
| B | GLN81 | |
| B | ARG105 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kim |
| Chain | Residue | Details |
| A | GLY30 | |
| A | ARG169 | |
| A | GLU52 | |
| A | ARG105 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kim |
| Chain | Residue | Details |
| B | GLY30 | |
| B | ARG169 | |
| B | GLU52 | |
| B | ARG105 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kim |
| Chain | Residue | Details |
| A | GLU52 | |
| A | ARG105 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1kim |
| Chain | Residue | Details |
| B | GLU52 | |
| B | ARG105 |
