Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004326 | molecular_function | tetrahydrofolylpolyglutamate synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006761 | biological_process | dihydrofolate biosynthetic process |
| A | 0008841 | molecular_function | dihydrofolate synthase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0016881 | molecular_function | acid-amino acid ligase activity |
| A | 0043531 | molecular_function | ADP binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046901 | biological_process | tetrahydrofolylpolyglutamate biosynthetic process |
| A | 0050897 | molecular_function | cobalt ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ACP A1490 |
| Chain | Residue |
| A | THR74 |
| A | HIS299 |
| A | ASN303 |
| A | ARG340 |
| A | ASP353 |
| A | ALA354 |
| A | HIS356 |
| A | GLY360 |
| A | ALA363 |
| A | VAL474 |
| A | CO1492 |
| A | ASN75 |
| A | HOH2096 |
| A | HOH2114 |
| A | GLY76 |
| A | LYS77 |
| A | THR78 |
| A | SER79 |
| A | SER100 |
| A | PRO101 |
| A | GLU176 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CO A1491 |
| Chain | Residue |
| A | ASP326 |
| A | HOH2116 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CO A1492 |
| Chain | Residue |
| A | THR78 |
| A | SER100 |
| A | GLU176 |
| A | ACP1490 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CO A1493 |
| Chain | Residue |
| A | HIS203 |
| A | ASP205 |
| A | HOH2117 |
| A | HOH2118 |
| A | HOH2119 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CO A1494 |
| Chain | Residue |
| A | HIS370 |
| A | ASP455 |
| A | ASP457 |
| A | HOH2120 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A1495 |
| Chain | Residue |
| A | THR74 |
| A | SER200 |
| A | ASP202 |
| A | HIS203 |
| A | LYS218 |
| A | HOH2121 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A1496 |
| Chain | Residue |
| A | ARG82 |
| A | ARG97 |
| A | GLY114 |
| A | ALA334 |
| A | THR336 |
| A | HOH2011 |
| A | HOH2122 |
Functional Information from PROSITE/UniProt
| site_id | PS01012 |
| Number of Residues | 16 |
| Details | FOLYLPOLYGLU_SYNT_2 Folylpolyglutamate synthase signature 2. VVEvGMGGrwDaTnVI |
| Chain | Residue | Details |
| A | VAL174-ILE189 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1p3d |
| Chain | Residue | Details |
| A | LYS77 | |
