2VOE

Crystal structure of Rv2780 from M. tuberculosis H37Rv

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000286	molecular_function	L-alanine dehydrogenase (NAD+) activity
A	0001666	biological_process	response to hypoxia
A	0005576	cellular_component	extracellular region
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006524	biological_process	obsolete alanine catabolic process
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016491	molecular_function	oxidoreductase activity
A	0042853	biological_process	L-alanine catabolic process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000286	molecular_function	L-alanine dehydrogenase (NAD+) activity
B	0001666	biological_process	response to hypoxia
B	0005576	cellular_component	extracellular region
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006524	biological_process	obsolete alanine catabolic process
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0016491	molecular_function	oxidoreductase activity
B	0042853	biological_process	L-alanine catabolic process
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000286	molecular_function	L-alanine dehydrogenase (NAD+) activity
C	0001666	biological_process	response to hypoxia
C	0005576	cellular_component	extracellular region
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006524	biological_process	obsolete alanine catabolic process
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0016491	molecular_function	oxidoreductase activity
C	0042853	biological_process	L-alanine catabolic process
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000286	molecular_function	L-alanine dehydrogenase (NAD+) activity
D	0001666	biological_process	response to hypoxia
D	0005576	cellular_component	extracellular region
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006524	biological_process	obsolete alanine catabolic process
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0016491	molecular_function	oxidoreductase activity
D	0042853	biological_process	L-alanine catabolic process
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0000286	molecular_function	L-alanine dehydrogenase (NAD+) activity
E	0001666	biological_process	response to hypoxia
E	0005576	cellular_component	extracellular region
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006524	biological_process	obsolete alanine catabolic process
E	0009274	cellular_component	peptidoglycan-based cell wall
E	0016491	molecular_function	oxidoreductase activity
E	0042853	biological_process	L-alanine catabolic process
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0000286	molecular_function	L-alanine dehydrogenase (NAD+) activity
F	0001666	biological_process	response to hypoxia
F	0005576	cellular_component	extracellular region
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006524	biological_process	obsolete alanine catabolic process
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0016491	molecular_function	oxidoreductase activity
F	0042853	biological_process	L-alanine catabolic process
F	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00836
Number of Residues	27
Details	ALADH_PNT_1 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1. GIPtEtknNEf..RVAiTPaGVaeLtRrG

Chain	Residue	Details
A	GLY4-GLY30

---

site_id	PS00837
Number of Residues	26
Details	ALADH_PNT_2 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. VIGAGtAGynAariAnGMGAtVtvlD

Chain	Residue	Details
A	VAL173-ASP198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"18304579","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18304579","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	78
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18304579","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18491387","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18304579","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VHX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1pjb

Chain	Residue	Details
A	GLU118
A	LYS75
A	ASP270
A	HIS96

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1pjb

Chain	Residue	Details
B	GLU118
B	LYS75
B	ASP270
B	HIS96

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1pjb

Chain	Residue	Details
C	GLU118
C	LYS75
C	ASP270
C	HIS96

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1pjb

Chain	Residue	Details
D	GLU118
D	LYS75
D	ASP270
D	HIS96

---

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1pjb

Chain	Residue	Details
E	GLU118
E	LYS75
E	ASP270
E	HIS96

---

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1pjb

Chain	Residue	Details
F	GLU118
F	LYS75
F	ASP270
F	HIS96

---