2VOE
Crystal structure of Rv2780 from M. tuberculosis H37Rv
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000286 | molecular_function | L-alanine dehydrogenase (NAD+) activity |
| A | 0001666 | biological_process | response to hypoxia |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042853 | biological_process | L-alanine catabolic process |
| B | 0000286 | molecular_function | L-alanine dehydrogenase (NAD+) activity |
| B | 0001666 | biological_process | response to hypoxia |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042853 | biological_process | L-alanine catabolic process |
| C | 0000286 | molecular_function | L-alanine dehydrogenase (NAD+) activity |
| C | 0001666 | biological_process | response to hypoxia |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0042853 | biological_process | L-alanine catabolic process |
| D | 0000286 | molecular_function | L-alanine dehydrogenase (NAD+) activity |
| D | 0001666 | biological_process | response to hypoxia |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0042853 | biological_process | L-alanine catabolic process |
| E | 0000286 | molecular_function | L-alanine dehydrogenase (NAD+) activity |
| E | 0001666 | biological_process | response to hypoxia |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0042853 | biological_process | L-alanine catabolic process |
| F | 0000286 | molecular_function | L-alanine dehydrogenase (NAD+) activity |
| F | 0001666 | biological_process | response to hypoxia |
| F | 0005576 | cellular_component | extracellular region |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0042853 | biological_process | L-alanine catabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00836 |
| Number of Residues | 27 |
| Details | ALADH_PNT_1 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1. GIPtEtknNEf..RVAiTPaGVaeLtRrG |
| Chain | Residue | Details |
| A | GLY4-GLY30 |
| site_id | PS00837 |
| Number of Residues | 26 |
| Details | ALADH_PNT_2 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. VIGAGtAGynAariAnGMGAtVtvlD |
| Chain | Residue | Details |
| A | VAL173-ASP198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"18304579","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18304579","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 78 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18304579","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18491387","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18304579","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VHX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1pjb |
| Chain | Residue | Details |
| A | GLU118 | |
| A | LYS75 | |
| A | ASP270 | |
| A | HIS96 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1pjb |
| Chain | Residue | Details |
| B | GLU118 | |
| B | LYS75 | |
| B | ASP270 | |
| B | HIS96 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1pjb |
| Chain | Residue | Details |
| C | GLU118 | |
| C | LYS75 | |
| C | ASP270 | |
| C | HIS96 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1pjb |
| Chain | Residue | Details |
| D | GLU118 | |
| D | LYS75 | |
| D | ASP270 | |
| D | HIS96 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1pjb |
| Chain | Residue | Details |
| E | GLU118 | |
| E | LYS75 | |
| E | ASP270 | |
| E | HIS96 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1pjb |
| Chain | Residue | Details |
| F | GLU118 | |
| F | LYS75 | |
| F | ASP270 | |
| F | HIS96 |
