2VO5
Structural and biochemical evidence for a boat-like transition state in beta-mannosidases
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
A | 0004567 | molecular_function | beta-mannosidase activity |
A | 0005576 | cellular_component | extracellular region |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0006516 | biological_process | glycoprotein catabolic process |
A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
B | 0004567 | molecular_function | beta-mannosidase activity |
B | 0005576 | cellular_component | extracellular region |
B | 0005975 | biological_process | carbohydrate metabolic process |
B | 0006516 | biological_process | glycoprotein catabolic process |
B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE VBZ A1865 |
Chain | Residue |
A | TRP198 |
A | TYR537 |
A | GLU555 |
A | TRP645 |
A | TRP656 |
A | EDO1872 |
A | ASP199 |
A | TRP200 |
A | TRP395 |
A | CYS424 |
A | ASN461 |
A | GLU462 |
A | TRP470 |
A | TRP533 |
site_id | AC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE VBZ B1868 |
Chain | Residue |
B | TRP198 |
B | ASP199 |
B | TRP200 |
B | TRP395 |
B | CYS424 |
B | ASN461 |
B | GLU462 |
B | TRP470 |
B | TRP533 |
B | TYR537 |
B | GLU555 |
B | TRP645 |
B | TRP656 |
B | EDO1869 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B1869 |
Chain | Residue |
B | TRP519 |
B | VBZ1868 |
B | HOH2280 |
B | HOH2475 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A1866 |
Chain | Residue |
A | ARG597 |
A | PRO607 |
A | GLU608 |
A | PHE610 |
A | PHE613 |
A | HOH2459 |
A | HOH2460 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A1867 |
Chain | Residue |
A | PHE42 |
A | GLN44 |
A | LYS49 |
A | MET51 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B1870 |
Chain | Residue |
B | GLN230 |
B | ARG331 |
B | HOH2205 |
B | HOH2476 |
site_id | AC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A1868 |
Chain | Residue |
A | ILE328 |
A | GLY329 |
A | ARG449 |
A | ASN450 |
A | HIS451 |
A | ALA452 |
A | ARG507 |
site_id | AC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO B1871 |
Chain | Residue |
B | ARG376 |
B | TYR661 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B1872 |
Chain | Residue |
B | ILE328 |
B | GLY329 |
B | ARG331 |
B | ASN450 |
B | HIS451 |
B | ALA452 |
site_id | BC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO B1873 |
Chain | Residue |
B | TYR347 |
B | HOH2328 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B1874 |
Chain | Residue |
B | GLN365 |
B | ASN648 |
B | ASP649 |
B | ILE659 |
B | ASP660 |
B | HOH2223 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A1869 |
Chain | Residue |
A | GLU465 |
A | LYS468 |
A | TYR469 |
A | PRO514 |
A | LEU516 |
A | ALA517 |
site_id | BC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO B1875 |
Chain | Residue |
A | THR432 |
B | LEU126 |
B | HOH2478 |
site_id | BC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO A1870 |
Chain | Residue |
A | TRP525 |
A | SER530 |
A | ASN532 |
A | ASP548 |
A | LEU549 |
A | PRO550 |
A | MET553 |
A | HOH2461 |
site_id | BC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B1876 |
Chain | Residue |
B | HIS326 |
B | ARG327 |
B | ASN450 |
B | HIS451 |
B | HOH2201 |
B | HOH2257 |
B | HOH2479 |
site_id | BC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A1871 |
Chain | Residue |
A | GLU816 |
A | LYS857 |
A | GLU563 |
A | MET564 |
A | GLU611 |
A | TYR615 |
A | PHE814 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B1877 |
Chain | Residue |
B | LEU164 |
B | HIS181 |
B | LYS183 |
B | HOH2043 |
site_id | BC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B1878 |
Chain | Residue |
B | TRP519 |
B | TRP525 |
B | ASN532 |
B | ASP548 |
B | MET553 |
B | HOH2314 |
site_id | CC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B1879 |
Chain | Residue |
B | SER43 |
B | GLN44 |
B | SER45 |
B | GLY46 |
B | GLU48 |
B | GLU90 |
site_id | CC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B1880 |
Chain | Residue |
B | GLU465 |
B | LYS468 |
B | TYR469 |
B | PRO514 |
B | LEU516 |
B | ALA517 |
B | ASN518 |
site_id | CC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B1881 |
Chain | Residue |
B | PHE42 |
B | SER43 |
B | GLN44 |
B | LYS49 |
B | MET51 |
B | HOH2012 |
site_id | CC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO B1882 |
Chain | Residue |
B | ARG626 |
B | PRO683 |
B | SER772 |
B | VAL773 |
B | HIS774 |
B | HOH2361 |
B | HOH2384 |
B | HOH2427 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A1872 |
Chain | Residue |
A | TRP519 |
A | TRP533 |
A | VBZ1865 |
A | HOH2280 |
site_id | CC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B1883 |
Chain | Residue |
B | ASN337 |
B | HIS511 |
B | TYR515 |
B | HOH2480 |
site_id | CC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A1873 |
Chain | Residue |
A | ARG626 |
A | VAL773 |
A | HIS774 |
A | PHE775 |
A | HOH2422 |
A | HOH2450 |
site_id | CC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE BR A1874 |
Chain | Residue |
A | ILE107 |
A | LYS142 |
site_id | CC9 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE BR A1875 |
Chain | Residue |
A | HIS284 |
site_id | DC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE BR B1884 |
Chain | Residue |
B | ILE107 |
B | LYS142 |
site_id | DC2 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE BR A1895 |
Chain | Residue |
B | HOH2294 |
site_id | DC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE BR B1885 |
Chain | Residue |
B | GLN685 |
B | ASP688 |
site_id | DC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE CL B1886 |
Chain | Residue |
B | GLN108 |
site_id | DC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL A1876 |
Chain | Residue |
A | GLN685 |
A | ASP688 |
site_id | DC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL B1887 |
Chain | Residue |
B | GLN685 |
B | HIS774 |
B | HOH2384 |
site_id | DC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A1877 |
Chain | Residue |
A | GLN685 |
A | HIS774 |
A | HOH2392 |
site_id | DC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL B1888 |
Chain | Residue |
B | PHE476 |
B | THR477 |
B | VAL480 |
site_id | DC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A1878 |
Chain | Residue |
A | ASN337 |
A | VAL510 |
A | HIS511 |
A | TYR515 |
A | HOH2216 |
A | HOH2463 |
site_id | EC1 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE CL B1896 |
Chain | Residue |
B | HOH2275 |
site_id | EC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO B1889 |
Chain | Residue |
B | GLN577 |
B | ILE578 |
B | ARG597 |
site_id | EC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A1879 |
Chain | Residue |
A | LEU244 |
A | HIS284 |
A | ILE285 |
A | THR286 |
A | HOH2464 |
site_id | EC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO B1890 |
Chain | Residue |
B | TYR863 |
B | LYS864 |
site_id | EC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B1891 |
Chain | Residue |
B | GLU48 |
B | TRP50 |
B | ARG92 |
B | HOH2481 |
site_id | EC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B1892 |
Chain | Residue |
B | PHE356 |
B | ARG633 |
B | ARG636 |
B | ILE695 |
B | SER696 |
B | ASP697 |
B | THR734 |
site_id | EC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A1880 |
Chain | Residue |
A | PRO70 |
A | ASN71 |
A | TYR74 |
A | ASN77 |
site_id | EC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A1881 |
Chain | Residue |
A | ASN518 |
A | TRP519 |
A | HOH2466 |
site_id | EC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE BR B1893 |
Chain | Residue |
B | ASN300 |
B | ASN390 |
site_id | FC1 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE BR A1882 |
Chain | Residue |
A | THR477 |
site_id | FC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A1883 |
Chain | Residue |
A | HIS326 |
A | ARG327 |
A | ASN450 |
A | HIS451 |
A | HOH2467 |
A | HOH2468 |
site_id | FC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE BR A1884 |
Chain | Residue |
A | GLN108 |
site_id | FC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A1885 |
Chain | Residue |
A | TYR74 |
A | ALA568 |
A | ALA571 |
A | ALA572 |
A | PRO573 |
A | TYR576 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1bgl |
Chain | Residue | Details |
A | GLU462 | |
A | GLU555 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1bgl |
Chain | Residue | Details |
B | GLU462 | |
B | GLU555 |