Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2VNT

Urokinase-Type Plasminogen Activator Inhibitor Complex with a 1-(7- SULPHOAMIDOISOQUINOLINYL)GUANIDINE

Replaces: 2JDE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0004252	molecular_function	serine-type endopeptidase activity
D	0006508	biological_process	proteolysis
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis
F	0004252	molecular_function	serine-type endopeptidase activity
F	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE QGG D1258

Chain	Residue
A	ASP59
D	TRP227
D	GLY228
D	ARG229
D	GLY230
D	CYS231
D	LYS236
D	GLY238
D	HOH2103
D	HOH2111
D	HOH2112
A	PRO61
D	ASP201
D	SER202
D	CYS203
D	GLN204
D	SER207
D	VAL225
D	SER226

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE QGG F1258

Chain	Residue
B	ILE58
B	ASP59
B	PRO61
F	ASP201
F	SER202
F	GLN204
F	SER207
F	VAL225
F	SER226
F	TRP227
F	GLY228
F	ARG229
F	GLY230
F	CYS231
F	LYS236
F	GLY238
F	HOH2091

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE QGG E1258

Chain	Residue
C	ASP59
E	ASP201
E	SER202
E	GLN204
E	SER207
E	VAL225
E	SER226
E	TRP227
E	GLY228
E	ARG229
E	GLY230
E	CYS231
E	LYS236
E	GLY238
E	HOH2114
E	HOH2121

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE QGG C1258

Chain	Residue
C	ASP201
C	SER202
C	GLN204
C	SER207
C	VAL225
C	SER226
C	TRP227
C	GLY228
C	ARG229
C	GLY230
C	LYS236
C	GLY238
C	HOH2090
C	HOH2105
C	HOH2106
E	ILE58
E	ASP59
E	HOH2024

site_id	AC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE QGG B1258

Chain	Residue
B	ASP201
B	SER202
B	CYS203
B	GLN204
B	SER207
B	VAL225
B	SER226
B	TRP227
B	GLY228
B	ARG229
B	GLY230
B	CYS231
B	PRO237
B	GLY238
B	HOH2035
B	HOH2084
F	ASP59

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE QGG A1258

Chain	Residue
A	HOH2090
D	ASP59
A	ASP201
A	SER202
A	GLN204
A	SER207
A	VAL225
A	TRP227
A	GLY228
A	ARG229
A	GLY230
A	CYS231
A	LYS236
A	GLY238

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B1259

Chain	Residue
B	ARG124
B	HOH2085
C	LYS151
E	ARG29
E	TYR60

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 E1259

Chain	Residue
B	ARG124
C	THR155
C	TYR157
E	ARG29
E	HIS31
E	ARG32
E	HOH2122

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B1260

Chain	Residue
B	ARG29
B	TYR60
D	ARG124
F	TYR157

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D1259

Chain	Residue
A	LYS151
D	ARG29
D	TYR60
D	HOH2113
E	ARG124

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B1261

Chain	Residue
B	ARG74
B	ASN76
B	SER77
D	ARG74
D	SER77
E	ARG74
E	SER77

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 E1260

Chain	Residue
B	SER77
B	ASN78
B	HOH2026
D	SER77
D	ASN78
D	HOH2034
E	ASN78
E	HOH2123
E	HOH2124

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D1260

Chain	Residue
A	THR155
A	TYR157
D	ARG29
D	HIS31
D	ARG32
D	HOH2016
D	HOH2113
E	ARG124

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B1262

Chain	Residue
B	HIS31
B	ARG32
D	ARG124
F	TYR157

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D1261

Chain	Residue
C	SER214
C	GLY217
D	HIS104
D	LYS189

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC

Chain	Residue	Details
A	ILE51-CYS56

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV

Chain	Residue	Details
A	ASP201-VAL212

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1470
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	18
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"9151681","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000026"}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	SER207
A	ASP106
A	HIS55
A	GLY205

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	SER207
A	GLY205

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
B	SER207
B	GLY205

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
C	SER207
C	GLY205

site_id	CSA13
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
D	SER207
D	GLY205

site_id	CSA14
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
E	SER207
E	GLY205

site_id	CSA15
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
F	SER207
F	GLY205

site_id	CSA16
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	SER207
A	GLY208

site_id	CSA17
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
B	SER207
B	GLY208

site_id	CSA18
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
C	SER207
C	GLY208

site_id	CSA19
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
D	SER207
D	GLY208

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
B	SER207
B	ASP106
B	HIS55
B	GLY205

site_id	CSA20
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
E	SER207
E	GLY208

site_id	CSA21
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
F	SER207
F	GLY208

site_id	CSA22
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
D	SER207
D	ASP106
D	HIS55
D	GLY205

site_id	CSA23
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
E	SER207
E	ASP106
E	HIS55
E	GLY205

site_id	CSA24
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
F	SER207
F	ASP106
F	HIS55
F	GLY205

site_id	CSA25
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	SER207
A	ASP106
A	HIS55

site_id	CSA26
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
B	SER207
B	ASP106
B	HIS55

site_id	CSA27
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
C	SER207
C	ASP106
C	HIS55

site_id	CSA28
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
D	SER207
D	ASP106
D	HIS55

site_id	CSA29
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
E	SER207
E	ASP106
E	HIS55

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
C	SER207
C	ASP106
C	HIS55
C	GLY205

site_id	CSA30
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
F	SER207
F	ASP106
F	HIS55

site_id	CSA31
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	SER207
A	GLY208
A	ASP106
A	HIS55

site_id	CSA32
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
B	SER207
B	GLY208
B	ASP106
B	HIS55

site_id	CSA33
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
C	SER207
C	GLY208
C	ASP106
C	HIS55

site_id	CSA34
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
D	SER207
D	GLY208
D	ASP106
D	HIS55

site_id	CSA35
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
E	SER207
E	GLY208
E	ASP106
E	HIS55

site_id	CSA36
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
F	SER207
F	GLY208
F	ASP106
F	HIS55

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
A	ASP106
A	HIS55

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
B	ASP106
B	HIS55

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
C	ASP106
C	HIS55

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
D	ASP106
D	HIS55

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
E	ASP106
E	HIS55

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
F	ASP106
F	HIS55

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)