2VNT

UROKINASE-TYPE PLASMINOGEN ACTIVATOR INHIBITOR COMPLEX WITH A 1-(7- SULPHOAMIDOISOQUINOLINYL)GUANIDINE

Replaces:  2JDE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0004252	molecular_function	serine-type endopeptidase activity
D	0006508	biological_process	proteolysis
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis
F	0004252	molecular_function	serine-type endopeptidase activity
F	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE QGG D1258

Chain	Residue
A	ASP59
D	TRP227
D	GLY228
D	ARG229
D	GLY230
D	CYS231
D	LYS236
D	GLY238
D	HOH2103
D	HOH2111
D	HOH2112
A	PRO61
D	ASP201
D	SER202
D	CYS203
D	GLN204
D	SER207
D	VAL225
D	SER226

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE QGG F1258

Chain	Residue
B	ILE58
B	ASP59
B	PRO61
F	ASP201
F	SER202
F	GLN204
F	SER207
F	VAL225
F	SER226
F	TRP227
F	GLY228
F	ARG229
F	GLY230
F	CYS231
F	LYS236
F	GLY238
F	HOH2091

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE QGG E1258

Chain	Residue
C	ASP59
E	ASP201
E	SER202
E	GLN204
E	SER207
E	VAL225
E	SER226
E	TRP227
E	GLY228
E	ARG229
E	GLY230
E	CYS231
E	LYS236
E	GLY238
E	HOH2114
E	HOH2121

---

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE QGG C1258

Chain	Residue
C	ASP201
C	SER202
C	GLN204
C	SER207
C	VAL225
C	SER226
C	TRP227
C	GLY228
C	ARG229
C	GLY230
C	LYS236
C	GLY238
C	HOH2090
C	HOH2105
C	HOH2106
E	ILE58
E	ASP59
E	HOH2024

---

site_id	AC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE QGG B1258

Chain	Residue
B	ASP201
B	SER202
B	CYS203
B	GLN204
B	SER207
B	VAL225
B	SER226
B	TRP227
B	GLY228
B	ARG229
B	GLY230
B	CYS231
B	PRO237
B	GLY238
B	HOH2035
B	HOH2084
F	ASP59

---

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE QGG A1258

Chain	Residue
A	HOH2090
D	ASP59
A	ASP201
A	SER202
A	GLN204
A	SER207
A	VAL225
A	TRP227
A	GLY228
A	ARG229
A	GLY230
A	CYS231
A	LYS236
A	GLY238

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B1259

Chain	Residue
B	ARG124
B	HOH2085
C	LYS151
E	ARG29
E	TYR60

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 E1259

Chain	Residue
B	ARG124
C	THR155
C	TYR157
E	ARG29
E	HIS31
E	ARG32
E	HOH2122

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B1260

Chain	Residue
B	ARG29
B	TYR60
D	ARG124
F	TYR157

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D1259

Chain	Residue
A	LYS151
D	ARG29
D	TYR60
D	HOH2113
E	ARG124

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B1261

Chain	Residue
B	ARG74
B	ASN76
B	SER77
D	ARG74
D	SER77
E	ARG74
E	SER77

---

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 E1260

Chain	Residue
B	SER77
B	ASN78
B	HOH2026
D	SER77
D	ASN78
D	HOH2034
E	ASN78
E	HOH2123
E	HOH2124

---

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D1260

Chain	Residue
A	THR155
A	TYR157
D	ARG29
D	HIS31
D	ARG32
D	HOH2016
D	HOH2113
E	ARG124

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B1262

Chain	Residue
B	HIS31
B	ARG32
D	ARG124
F	TYR157

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D1261

Chain	Residue
C	SER214
C	GLY217
D	HIS104
D	LYS189

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC

Chain	Residue	Details
A	ILE51-CYS56

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV

Chain	Residue	Details
A	ASP201-VAL212

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
A	HIS55
D	HIS55
D	ASP106
D	SER207
E	HIS55
E	ASP106
E	SER207
F	HIS55
F	ASP106
F	SER207
A	ASP106
A	SER207
B	HIS55
B	ASP106
B	SER207
C	HIS55
C	ASP106
C	SER207

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Cleavage; during zymogen activation

Chain	Residue	Details
A	PHE9
B	PHE9
C	PHE9
D	PHE9
E	PHE9
F	PHE9

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:9151681

Chain	Residue	Details
A	SER-9
E	SER154
F	SER-9
F	SER154
A	SER154
B	SER-9
B	SER154
C	SER-9
C	SER154
D	SER-9
D	SER154
E	SER-9

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine

Chain	Residue	Details
A	ASN153
B	ASN153
C	ASN153
D	ASN153
E	ASN153
F	ASN153

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