Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0006508 | biological_process | proteolysis |
| F | 0004252 | molecular_function | serine-type endopeptidase activity |
| F | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE QGG D1258 |
| Chain | Residue |
| A | ASP59 |
| D | TRP227 |
| D | GLY228 |
| D | ARG229 |
| D | GLY230 |
| D | CYS231 |
| D | LYS236 |
| D | GLY238 |
| D | HOH2103 |
| D | HOH2111 |
| D | HOH2112 |
| A | PRO61 |
| D | ASP201 |
| D | SER202 |
| D | CYS203 |
| D | GLN204 |
| D | SER207 |
| D | VAL225 |
| D | SER226 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE QGG F1258 |
| Chain | Residue |
| B | ILE58 |
| B | ASP59 |
| B | PRO61 |
| F | ASP201 |
| F | SER202 |
| F | GLN204 |
| F | SER207 |
| F | VAL225 |
| F | SER226 |
| F | TRP227 |
| F | GLY228 |
| F | ARG229 |
| F | GLY230 |
| F | CYS231 |
| F | LYS236 |
| F | GLY238 |
| F | HOH2091 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE QGG E1258 |
| Chain | Residue |
| C | ASP59 |
| E | ASP201 |
| E | SER202 |
| E | GLN204 |
| E | SER207 |
| E | VAL225 |
| E | SER226 |
| E | TRP227 |
| E | GLY228 |
| E | ARG229 |
| E | GLY230 |
| E | CYS231 |
| E | LYS236 |
| E | GLY238 |
| E | HOH2114 |
| E | HOH2121 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE QGG C1258 |
| Chain | Residue |
| C | ASP201 |
| C | SER202 |
| C | GLN204 |
| C | SER207 |
| C | VAL225 |
| C | SER226 |
| C | TRP227 |
| C | GLY228 |
| C | ARG229 |
| C | GLY230 |
| C | LYS236 |
| C | GLY238 |
| C | HOH2090 |
| C | HOH2105 |
| C | HOH2106 |
| E | ILE58 |
| E | ASP59 |
| E | HOH2024 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE QGG B1258 |
| Chain | Residue |
| B | ASP201 |
| B | SER202 |
| B | CYS203 |
| B | GLN204 |
| B | SER207 |
| B | VAL225 |
| B | SER226 |
| B | TRP227 |
| B | GLY228 |
| B | ARG229 |
| B | GLY230 |
| B | CYS231 |
| B | PRO237 |
| B | GLY238 |
| B | HOH2035 |
| B | HOH2084 |
| F | ASP59 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE QGG A1258 |
| Chain | Residue |
| A | HOH2090 |
| D | ASP59 |
| A | ASP201 |
| A | SER202 |
| A | GLN204 |
| A | SER207 |
| A | VAL225 |
| A | TRP227 |
| A | GLY228 |
| A | ARG229 |
| A | GLY230 |
| A | CYS231 |
| A | LYS236 |
| A | GLY238 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B1259 |
| Chain | Residue |
| B | ARG124 |
| B | HOH2085 |
| C | LYS151 |
| E | ARG29 |
| E | TYR60 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 E1259 |
| Chain | Residue |
| B | ARG124 |
| C | THR155 |
| C | TYR157 |
| E | ARG29 |
| E | HIS31 |
| E | ARG32 |
| E | HOH2122 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B1260 |
| Chain | Residue |
| B | ARG29 |
| B | TYR60 |
| D | ARG124 |
| F | TYR157 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D1259 |
| Chain | Residue |
| A | LYS151 |
| D | ARG29 |
| D | TYR60 |
| D | HOH2113 |
| E | ARG124 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B1261 |
| Chain | Residue |
| B | ARG74 |
| B | ASN76 |
| B | SER77 |
| D | ARG74 |
| D | SER77 |
| E | ARG74 |
| E | SER77 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 E1260 |
| Chain | Residue |
| B | SER77 |
| B | ASN78 |
| B | HOH2026 |
| D | SER77 |
| D | ASN78 |
| D | HOH2034 |
| E | ASN78 |
| E | HOH2123 |
| E | HOH2124 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 D1260 |
| Chain | Residue |
| A | THR155 |
| A | TYR157 |
| D | ARG29 |
| D | HIS31 |
| D | ARG32 |
| D | HOH2016 |
| D | HOH2113 |
| E | ARG124 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B1262 |
| Chain | Residue |
| B | HIS31 |
| B | ARG32 |
| D | ARG124 |
| F | TYR157 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D1261 |
| Chain | Residue |
| C | SER214 |
| C | GLY217 |
| D | HIS104 |
| D | LYS189 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC |
| Chain | Residue | Details |
| A | ILE51-CYS56 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV |
| Chain | Residue | Details |
| A | ASP201-VAL212 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | HIS55 | |
| D | HIS55 | |
| D | ASP106 | |
| D | SER207 | |
| E | HIS55 | |
| E | ASP106 | |
| E | SER207 | |
| F | HIS55 | |
| F | ASP106 | |
| F | SER207 | |
| A | ASP106 | |
| A | SER207 | |
| B | HIS55 | |
| B | ASP106 | |
| B | SER207 | |
| C | HIS55 | |
| C | ASP106 | |
| C | SER207 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | SITE: Cleavage; during zymogen activation |
| Chain | Residue | Details |
| A | PHE9 | |
| B | PHE9 | |
| C | PHE9 | |
| D | PHE9 | |
| E | PHE9 | |
| F | PHE9 | |
| Chain | Residue | Details |
| A | SER-9 | |
| E | SER154 | |
| F | SER-9 | |
| F | SER154 | |
| A | SER154 | |
| B | SER-9 | |
| B | SER154 | |
| C | SER-9 | |
| C | SER154 | |
| D | SER-9 | |
| D | SER154 | |
| E | SER-9 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine |
| Chain | Residue | Details |
| A | ASN153 | |
| B | ASN153 | |
| C | ASN153 | |
| D | ASN153 | |
| E | ASN153 | |
| F | ASN153 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER207 | |
| A | ASP106 | |
| A | HIS55 | |
| A | GLY205 | |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER207 | |
| A | GLY205 | |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER207 | |
| B | GLY205 | |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | SER207 | |
| C | GLY205 | |
| site_id | CSA13 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | SER207 | |
| D | GLY205 | |
| site_id | CSA14 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| E | SER207 | |
| E | GLY205 | |
| site_id | CSA15 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| F | SER207 | |
| F | GLY205 | |
| site_id | CSA16 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER207 | |
| A | GLY208 | |
| site_id | CSA17 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER207 | |
| B | GLY208 | |
| site_id | CSA18 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | SER207 | |
| C | GLY208 | |
| site_id | CSA19 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | SER207 | |
| D | GLY208 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER207 | |
| B | ASP106 | |
| B | HIS55 | |
| B | GLY205 | |
| site_id | CSA20 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| E | SER207 | |
| E | GLY208 | |
| site_id | CSA21 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| F | SER207 | |
| F | GLY208 | |
| site_id | CSA22 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | SER207 | |
| D | ASP106 | |
| D | HIS55 | |
| D | GLY205 | |
| site_id | CSA23 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| E | SER207 | |
| E | ASP106 | |
| E | HIS55 | |
| E | GLY205 | |
| site_id | CSA24 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| F | SER207 | |
| F | ASP106 | |
| F | HIS55 | |
| F | GLY205 | |
| site_id | CSA25 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER207 | |
| A | ASP106 | |
| A | HIS55 | |
| site_id | CSA26 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER207 | |
| B | ASP106 | |
| B | HIS55 | |
| site_id | CSA27 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | SER207 | |
| C | ASP106 | |
| C | HIS55 | |
| site_id | CSA28 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | SER207 | |
| D | ASP106 | |
| D | HIS55 | |
| site_id | CSA29 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| E | SER207 | |
| E | ASP106 | |
| E | HIS55 | |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | SER207 | |
| C | ASP106 | |
| C | HIS55 | |
| C | GLY205 | |
| site_id | CSA30 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| F | SER207 | |
| F | ASP106 | |
| F | HIS55 | |
| site_id | CSA31 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER207 | |
| A | GLY208 | |
| A | ASP106 | |
| A | HIS55 | |
| site_id | CSA32 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER207 | |
| B | GLY208 | |
| B | ASP106 | |
| B | HIS55 | |
| site_id | CSA33 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | SER207 | |
| C | GLY208 | |
| C | ASP106 | |
| C | HIS55 | |
| site_id | CSA34 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | SER207 | |
| D | GLY208 | |
| D | ASP106 | |
| D | HIS55 | |
| site_id | CSA35 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| E | SER207 | |
| E | GLY208 | |
| E | ASP106 | |
| E | HIS55 | |
| site_id | CSA36 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| F | SER207 | |
| F | GLY208 | |
| F | ASP106 | |
| F | HIS55 | |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP106 | |
| A | HIS55 | |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP106 | |
| B | HIS55 | |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| C | ASP106 | |
| C | HIS55 | |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | ASP106 | |
| D | HIS55 | |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| E | ASP106 | |
| E | HIS55 | |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| F | ASP106 | |
| F | HIS55 | |
