2VN8
Crystal structure of human Reticulon 4 interacting protein 1 in complex with NADPH
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NDP A 600 |
| Chain | Residue |
| A | PRO85 |
| A | SER237 |
| A | TYR255 |
| A | ASN276 |
| A | VAL277 |
| A | LEU300 |
| A | VAL301 |
| A | ALA341 |
| A | PHE342 |
| A | PHE343 |
| A | HIS386 |
| A | TYR183 |
| A | ALA387 |
| A | ARG388 |
| A | HOH2078 |
| A | HOH2086 |
| A | HOH2087 |
| A | HOH2103 |
| A | HOH2118 |
| A | HOH2168 |
| A | HOH2169 |
| A | HOH2170 |
| A | THR187 |
| A | HOH2171 |
| A | HOH2172 |
| A | HOH2173 |
| A | HOH2174 |
| A | GLY212 |
| A | SER214 |
| A | GLY215 |
| A | GLY216 |
| A | VAL217 |
| A | VAL235 |
| site_id | AC2 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NDP B 600 |
| Chain | Residue |
| B | PRO85 |
| B | TYR183 |
| B | THR187 |
| B | GLY212 |
| B | SER214 |
| B | GLY215 |
| B | GLY216 |
| B | VAL217 |
| B | SER237 |
| B | TYR255 |
| B | ASN276 |
| B | VAL277 |
| B | LEU300 |
| B | VAL301 |
| B | ALA341 |
| B | PHE342 |
| B | PHE343 |
| B | HIS386 |
| B | ALA387 |
| B | ARG388 |
| B | HOH2042 |
| B | HOH2064 |
| B | HOH2096 |
| B | HOH2097 |
| B | HOH2099 |
| B | HOH2100 |
| B | HOH2101 |
| B | HOH2102 |
| B | HOH2103 |
| B | HOH2104 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A1397 |
| Chain | Residue |
| A | THR176 |
| A | ASN394 |
| A | CIT1398 |
| A | HOH2167 |
| A | HOH2177 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B1397 |
| Chain | Residue |
| A | MET128 |
| B | TRP292 |
| B | PHE332 |
| B | GLY335 |
| B | VAL336 |
| B | HIS337 |
| B | HOH2078 |
| B | HOH2105 |
| B | HOH2106 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CIT A1398 |
| Chain | Residue |
| A | HIS79 |
| A | THR174 |
| A | HIS175 |
| A | THR176 |
| A | NA1397 |
| A | HOH2167 |
| A | HOH2175 |
| A | HOH2176 |
| A | HOH2177 |
| A | HOH2178 |
Functional Information from PROSITE/UniProt
| site_id | PS01162 |
| Number of Residues | 22 |
| Details | QOR_ZETA_CRYSTAL Quinone oxidoreductase / zeta-crystallin signature. GKrvLilgASGGvGtfaiQvmK |
| Chain | Residue | Details |
| A | GLY205-LYS226 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 682 |
| Details | Domain: {"description":"Enoyl reductase (ER)","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2008","submissionDatabase":"PDB data bank","title":"Crystal Structure of Human Reticulon 4 Interacting Protein 1 in Complex with Nadph.","authors":["Pike A.C.W.","Guo K.","Elkins J.","Ugochukwu E.","Roos A.K.","Filippakopoulos P.","von Delft F.","Edwards A.","Arrowsmith C.H.","Weigelt J.","Bountra C.","Oppermann U."]}},{"source":"PDB","id":"2VN8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1guf |
| Chain | Residue | Details |
| A | ASN100 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1guf |
| Chain | Residue | Details |
| B | ASN100 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1guf |
| Chain | Residue | Details |
| A | MET101 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1guf |
| Chain | Residue | Details |
| B | MET101 |
