2VL4
Structural and biochemical evidence for a boat-like transition state in beta-mannosidases
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
A | 0004567 | molecular_function | beta-mannosidase activity |
A | 0005576 | cellular_component | extracellular region |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0006516 | biological_process | glycoprotein catabolic process |
A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
B | 0004567 | molecular_function | beta-mannosidase activity |
B | 0005576 | cellular_component | extracellular region |
B | 0005975 | biological_process | carbohydrate metabolic process |
B | 0006516 | biological_process | glycoprotein catabolic process |
B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE MNM A 1865 |
Chain | Residue |
A | TRP198 |
A | GLU555 |
A | TRP645 |
A | EDO1866 |
A | ASP199 |
A | TRP200 |
A | TRP395 |
A | CYS424 |
A | ASN461 |
A | GLU462 |
A | TRP533 |
A | TYR537 |
site_id | AC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE MNM B 1868 |
Chain | Residue |
B | TRP198 |
B | ASP199 |
B | TRP200 |
B | TRP395 |
B | CYS424 |
B | ASN461 |
B | GLU462 |
B | TRP533 |
B | TYR537 |
B | GLU555 |
B | TRP645 |
B | TRP656 |
B | EDO1882 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 1866 |
Chain | Residue |
A | ASN178 |
A | ASP199 |
A | CYS424 |
A | GLU462 |
A | TRP470 |
A | MNM1865 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B 1869 |
Chain | Residue |
B | GLN365 |
B | ASN648 |
B | ASP649 |
B | ILE659 |
B | ASP660 |
B | HOH2372 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B 1870 |
Chain | Residue |
B | TYR347 |
B | HOH2349 |
B | HOH2586 |
B | HOH2743 |
site_id | AC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO B 1871 |
Chain | Residue |
B | ILE328 |
B | GLY329 |
B | ARG449 |
B | ASN450 |
B | HIS451 |
B | ALA452 |
B | ARG507 |
B | HOH2238 |
site_id | AC7 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE EDO B 1872 |
Chain | Residue |
B | TYR661 |
site_id | AC8 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO A 1867 |
Chain | Residue |
A | ILE328 |
A | GLY329 |
A | ARG449 |
A | ASN450 |
A | HIS451 |
A | ALA452 |
A | ARG507 |
A | HOH2693 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 1868 |
Chain | Residue |
A | GLN365 |
A | ASN648 |
A | ASP649 |
A | ILE659 |
A | ASP660 |
site_id | BC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 1873 |
Chain | Residue |
B | PHE42 |
B | SER43 |
B | GLN44 |
B | THR47 |
B | LYS49 |
B | HOH2020 |
B | HOH2744 |
site_id | BC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO B 1874 |
Chain | Residue |
B | PHE356 |
B | ARG633 |
B | ARG636 |
B | ILE695 |
B | SER696 |
B | ASP697 |
B | ASN733 |
B | THR734 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 1869 |
Chain | Residue |
A | SER43 |
A | GLN44 |
A | THR47 |
A | LYS49 |
A | HOH2689 |
site_id | BC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 1875 |
Chain | Residue |
B | SER43 |
B | GLN44 |
B | SER45 |
B | GLY46 |
B | THR47 |
B | GLU48 |
B | GLU90 |
site_id | BC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 1876 |
Chain | Residue |
B | HIS326 |
B | ARG327 |
B | ASN450 |
B | HIS451 |
B | HOH2332 |
B | HOH2448 |
B | HOH2746 |
site_id | BC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 1870 |
Chain | Residue |
A | GLU608 |
A | HOH2690 |
A | ARG597 |
A | PRO607 |
site_id | BC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A 1871 |
Chain | Residue |
A | GLU465 |
A | LYS468 |
A | TYR469 |
A | PRO514 |
A | LEU516 |
A | ALA517 |
A | ASN518 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 1877 |
Chain | Residue |
B | TRP519 |
B | TRP533 |
B | TYR537 |
B | HOH2454 |
B | HOH2747 |
site_id | BC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B 1878 |
Chain | Residue |
B | ARG626 |
B | HIS774 |
B | PHE775 |
B | EDO1891 |
B | HOH2669 |
B | HOH2748 |
site_id | CC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO A 1872 |
Chain | Residue |
A | TRP525 |
A | SER530 |
A | ASN532 |
A | ASP548 |
A | LEU549 |
A | PRO550 |
A | MET553 |
A | HOH2473 |
site_id | CC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 1873 |
Chain | Residue |
A | ARG331 |
A | ARG507 |
A | HOH2691 |
A | HOH2692 |
A | HOH2693 |
site_id | CC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 1879 |
Chain | Residue |
B | ASN337 |
B | VAL510 |
B | HIS511 |
B | TYR515 |
B | HOH2361 |
B | HOH2749 |
B | HOH2750 |
site_id | CC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B 1880 |
Chain | Residue |
A | HIS157 |
A | ARG161 |
B | ASP88 |
B | HIS157 |
B | GLN162 |
B | HOH2751 |
site_id | CC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A 1874 |
Chain | Residue |
A | SER43 |
A | GLN44 |
A | SER45 |
A | GLY46 |
A | THR47 |
A | GLU48 |
A | GLU90 |
site_id | CC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B 1881 |
Chain | Residue |
B | GLU465 |
B | LYS468 |
B | TYR469 |
B | PRO514 |
B | LEU516 |
B | ALA517 |
site_id | CC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B 1882 |
Chain | Residue |
B | ASN178 |
B | ASP199 |
B | CYS424 |
B | GLU462 |
B | TRP470 |
B | MNM1868 |
site_id | CC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 1875 |
Chain | Residue |
A | GLN685 |
A | PHE775 |
A | PHE776 |
A | ARG777 |
A | LYS778 |
A | HOH2694 |
site_id | CC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 1883 |
Chain | Residue |
B | ASN300 |
B | TRP302 |
B | PHE356 |
B | LYS358 |
B | ASN390 |
B | ASP697 |
B | HOH2752 |
site_id | DC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A 1876 |
Chain | Residue |
A | ASN300 |
A | TRP302 |
A | PHE356 |
A | ASN390 |
A | ASP697 |
A | HOH2345 |
A | HOH2609 |
site_id | DC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 1877 |
Chain | Residue |
A | HIS326 |
A | ARG327 |
A | ASN450 |
A | HIS451 |
A | HOH2318 |
A | HOH2418 |
site_id | DC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE BR A 1878 |
Chain | Residue |
A | ILE107 |
A | LYS142 |
site_id | DC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE BR A 1879 |
Chain | Residue |
A | HIS284 |
site_id | DC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE BR B 1884 |
Chain | Residue |
B | ILE107 |
B | LYS142 |
site_id | DC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE BR A 1880 |
Chain | Residue |
A | HIS627 |
A | ILE684 |
A | GLN685 |
A | HIS774 |
A | HOH2579 |
site_id | DC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE BR B 1885 |
Chain | Residue |
B | GLN685 |
B | ASP688 |
site_id | DC8 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE BR A 1881 |
Chain | Residue |
A | HOH2458 |
site_id | DC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE BR B 1886 |
Chain | Residue |
B | HOH2478 |
B | HOH2480 |
B | HOH2750 |
site_id | EC1 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE BR A 1882 |
Chain | Residue |
A | GLN108 |
site_id | EC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE BR A 1883 |
Chain | Residue |
A | GLN685 |
A | ASP688 |
site_id | EC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE BR B 1887 |
Chain | Residue |
B | GLN108 |
site_id | EC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 1884 |
Chain | Residue |
A | TRP519 |
A | HOH2695 |
A | HOH2696 |
A | HOH2697 |
site_id | EC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL A 1889 |
Chain | Residue |
A | ASN77 |
A | HOH2044 |
site_id | EC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 1888 |
Chain | Residue |
A | ALA168 |
B | ARG92 |
B | TYR153 |
B | HOH2753 |
B | HOH2754 |
site_id | EC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL A 1885 |
Chain | Residue |
A | ASN402 |
A | HOH2041 |
site_id | EC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL B 1889 |
Chain | Residue |
B | ILE684 |
B | GLN685 |
B | EDO1891 |
B | HOH2609 |
site_id | EC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 1890 |
Chain | Residue |
B | ARG382 |
B | ARG823 |
B | TYR824 |
B | SER825 |
B | ILE840 |
B | THR842 |
B | HOH2755 |
site_id | FC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE BR A 1886 |
Chain | Residue |
A | PHE476 |
A | THR477 |
A | HOH2430 |
site_id | FC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 1887 |
Chain | Residue |
A | ASN293 |
A | HOH2224 |
A | HOH2698 |
B | GLY266 |
B | THR267 |
site_id | FC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 1891 |
Chain | Residue |
B | GLN685 |
B | PHE775 |
B | PHE776 |
B | ARG777 |
B | LYS778 |
B | EDO1878 |
B | CL1889 |
site_id | FC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE EDO B 1892 |
Chain | Residue |
B | SER143 |
site_id | FC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 1893 |
Chain | Residue |
B | VAL372 |
B | THR374 |
B | TYR377 |
B | ASN402 |
B | LEU404 |
B | HOH2756 |
B | HOH2757 |
site_id | FC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL B 1894 |
Chain | Residue |
B | GLN230 |
B | HOH2239 |
B | HOH2243 |
site_id | FC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO A 1888 |
Chain | Residue |
A | HIS774 |
A | PHE775 |
A | HOH2634 |
A | HOH2699 |
A | HOH2700 |
site_id | FC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO B 1895 |
Chain | Residue |
B | CYS737 |
B | ARG740 |
B | HOH2758 |
site_id | FC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL B 1896 |
Chain | Residue |
A | HOH2353 |
B | ASP797 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1bgl |
Chain | Residue | Details |
A | GLU462 | |
A | GLU555 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1bgl |
Chain | Residue | Details |
B | GLU462 | |
B | GLU555 |