2VKQ

Crystal structure of human cytosolic 5'-nucleotidase III (cN-III, NT5C3) in complex with beryllium trifluoride

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005737	cellular_component	cytoplasm
A	0008253	molecular_function	5'-nucleotidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BEF A 1287

Chain	Residue
A	ASP38
A	PHE39
A	ASP40
A	SER153
A	ALA154
A	LYS202
A	MG1288
A	HOH2003

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1288

Chain	Residue
A	ASP40
A	ASP227
A	BEF1287
A	HOH2021
A	ASP38

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:17405878

Chain	Residue	Details
A	VAL89

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000269|PubMed:17405878

Chain	Residue	Details
A	THR91

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:17405878

Chain	Residue	Details
A	VAL89
A	THR91
A	ASP204
A	ALA278

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9W197

Chain	Residue	Details
A	GLU136
A	GLY157

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9D020

Chain	Residue	Details
A	ARG253

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9D020

Chain	Residue	Details
A	ASN279

---