2VKH
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LETHAL TOXIN FROM CLOSTRIDIUM SORDELLII IN COMPLEX WITH UDP-GLC AND CALCIUM ION
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A1543 |
| Chain | Residue |
| A | ASP288 |
| A | GLU515 |
| A | SER518 |
| A | UPG1544 |
| A | HOH2064 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE UPG A1544 |
| Chain | Residue |
| A | LEU265 |
| A | ALA266 |
| A | SER269 |
| A | ASP270 |
| A | ARG273 |
| A | TYR284 |
| A | ASP286 |
| A | VAL287 |
| A | ASP288 |
| A | ASN384 |
| A | GLN385 |
| A | THR465 |
| A | SER518 |
| A | CA1543 |
| A | HOH2034 |
| A | HOH2064 |
| A | ILE101 |
| A | TRP102 |
| A | ILE103 |
| A | ASN139 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B1543 |
| Chain | Residue |
| B | ASP288 |
| B | GLU515 |
| B | SER518 |
| B | UPG1544 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE UPG B1544 |
| Chain | Residue |
| B | ILE101 |
| B | TRP102 |
| B | ILE103 |
| B | ASN139 |
| B | ALA266 |
| B | SER269 |
| B | ASP270 |
| B | ARG273 |
| B | TYR284 |
| B | ASP286 |
| B | VAL287 |
| B | ASP288 |
| B | ASN384 |
| B | GLN385 |
| B | THR465 |
| B | GLY470 |
| B | SER518 |
| B | CA1543 |
| B | HOH2031 |
| B | HOH2060 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA C1543 |
| Chain | Residue |
| C | ASP288 |
| C | GLU515 |
| C | SER518 |
| C | UPG1544 |
| C | HOH2044 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE UPG C1544 |
| Chain | Residue |
| C | ILE101 |
| C | TRP102 |
| C | ILE103 |
| C | ASN139 |
| C | LEU265 |
| C | ALA266 |
| C | SER269 |
| C | ASP270 |
| C | ARG273 |
| C | TYR284 |
| C | ASP286 |
| C | VAL287 |
| C | ASP288 |
| C | ASN384 |
| C | GLN385 |
| C | THR465 |
| C | SER518 |
| C | CA1543 |
| C | HOH2042 |
| C | HOH2044 |
| C | HOH2075 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18325534, ECO:0000269|PubMed:18505687, ECO:0007744|PDB:2VKD, ECO:0007744|PDB:2VKH, ECO:0007744|PDB:2VL8 |
| Chain | Residue | Details |
| A | ILE101 | |
| C | ASN139 | |
| C | LEU265 | |
| C | ASP286 | |
| A | ASN139 | |
| A | LEU265 | |
| A | ASP286 | |
| B | ILE101 | |
| B | ASN139 | |
| B | LEU265 | |
| B | ASP286 | |
| C | ILE101 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18325534, ECO:0007744|PDB:2VKD, ECO:0007744|PDB:2VKH |
| Chain | Residue | Details |
| A | ASP288 | |
| A | GLU515 | |
| B | ASP288 | |
| B | GLU515 | |
| C | ASP288 | |
| C | GLU515 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18325534, ECO:0000269|PubMed:18505687, ECO:0007744|PDB:2VKH, ECO:0007744|PDB:2VL8 |
| Chain | Residue | Details |
| A | SER518 | |
| B | SER518 | |
| C | SER518 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P16154 |
| Chain | Residue | Details |
| A | GLU545 | |
| B | GLU545 | |
| C | GLU545 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P18177 |
| Chain | Residue | Details |
| A | ASP546 | |
| B | ASP546 | |
| C | ASP546 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P18177 |
| Chain | Residue | Details |
| A | LEU543 | |
| B | LEU543 | |
| C | LEU543 |
