2VK3

Crystal structure of rat profilin 2a

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0003785	molecular_function	actin monomer binding
A	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0010633	biological_process	negative regulation of epithelial cell migration
A	0016887	molecular_function	ATP hydrolysis activity
A	0030036	biological_process	actin cytoskeleton organization
A	0030833	biological_process	regulation of actin filament polymerization
A	0030837	biological_process	negative regulation of actin filament polymerization
A	0030838	biological_process	positive regulation of actin filament polymerization
A	0032233	biological_process	positive regulation of actin filament bundle assembly
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0050821	biological_process	protein stabilization
A	0051496	biological_process	positive regulation of stress fiber assembly
A	0098685	cellular_component	Schaffer collateral - CA1 synapse
A	0098793	cellular_component	presynapse
A	0098794	cellular_component	postsynapse
A	0098885	biological_process	modification of postsynaptic actin cytoskeleton
A	0098978	cellular_component	glutamatergic synapse
A	0099140	biological_process	presynaptic actin cytoskeleton organization
A	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
A	1900028	biological_process	negative regulation of ruffle assembly
A	2000300	biological_process	regulation of synaptic vesicle exocytosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DTU A 1140

Chain	Residue
A	CYS25
A	GLY106
A	HOH2217

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DTU A 1141

Chain	Residue
A	CYS12
A	PHE59
A	THR60
A	HOH2218

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site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 1142

Chain	Residue
A	GLY2
A	TRP3
A	TYR6
A	TYR133
A	LEU134
A	GOL1143
A	HOH2050
A	HOH2219
A	HOH2220
A	GLY-2
A	SER-1

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site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1143

Chain	Residue
A	GLY-2
A	GLN17
A	GLU95
A	TYR98
A	MET113
A	SER137
A	GOL1142
A	HOH2050

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site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1144

Chain	Residue
A	ARG104
A	ARG135

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P35080","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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