2VJY
Pyruvate decarboxylase from Kluyveromyces lactis in complex with the substrate analogue methyl acetylphosphonate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
A | 0003824 | molecular_function | catalytic activity |
A | 0004737 | molecular_function | pyruvate decarboxylase activity |
A | 0005634 | cellular_component | nucleus |
A | 0005829 | cellular_component | cytosol |
A | 0016831 | molecular_function | carboxy-lyase activity |
A | 0030976 | molecular_function | thiamine pyrophosphate binding |
A | 0046872 | molecular_function | metal ion binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
B | 0003824 | molecular_function | catalytic activity |
B | 0004737 | molecular_function | pyruvate decarboxylase activity |
B | 0005634 | cellular_component | nucleus |
B | 0005829 | cellular_component | cytosol |
B | 0016831 | molecular_function | carboxy-lyase activity |
B | 0030976 | molecular_function | thiamine pyrophosphate binding |
B | 0046872 | molecular_function | metal ion binding |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
C | 0003824 | molecular_function | catalytic activity |
C | 0004737 | molecular_function | pyruvate decarboxylase activity |
C | 0005634 | cellular_component | nucleus |
C | 0005829 | cellular_component | cytosol |
C | 0016831 | molecular_function | carboxy-lyase activity |
C | 0030976 | molecular_function | thiamine pyrophosphate binding |
C | 0046872 | molecular_function | metal ion binding |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
D | 0003824 | molecular_function | catalytic activity |
D | 0004737 | molecular_function | pyruvate decarboxylase activity |
D | 0005634 | cellular_component | nucleus |
D | 0005829 | cellular_component | cytosol |
D | 0016831 | molecular_function | carboxy-lyase activity |
D | 0030976 | molecular_function | thiamine pyrophosphate binding |
D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE TPP A 600 |
Chain | Residue |
A | GLY389 |
A | ASN471 |
A | GLY473 |
A | TYR474 |
A | THR475 |
A | ILE476 |
A | GLU477 |
A | MG601 |
A | ALK602 |
A | HOH2209 |
A | HOH2238 |
A | THR390 |
A | HOH2298 |
B | PRO26 |
B | GLY27 |
B | GLU51 |
B | VAL76 |
B | HIS115 |
A | GLY413 |
A | SER414 |
A | ILE415 |
A | GLY443 |
A | ASP444 |
A | GLY445 |
A | SER446 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 601 |
Chain | Residue |
A | ASP444 |
A | ASN471 |
A | GLY473 |
A | TPP600 |
A | HOH2238 |
site_id | AC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE ALK A 602 |
Chain | Residue |
A | PHE292 |
A | THR388 |
A | GLU477 |
A | ILE480 |
A | TPP600 |
B | GLY27 |
B | ASP28 |
B | HIS114 |
B | HIS115 |
B | HOH2042 |
site_id | AC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE ALK A 603 |
Chain | Residue |
A | HIS92 |
A | CYS221 |
A | HIS225 |
A | GLY286 |
A | ALA287 |
A | HIS310 |
A | SER311 |
A | HOH2299 |
A | HOH2300 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ALU A 604 |
Chain | Residue |
A | GLN16 |
A | VAL17 |
A | GLU18 |
A | LYS65 |
A | TYR157 |
site_id | AC6 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE TPP B 600 |
Chain | Residue |
A | PRO26 |
A | GLY27 |
A | GLU51 |
A | VAL76 |
A | HIS115 |
B | THR390 |
B | GLY413 |
B | SER414 |
B | ILE415 |
B | GLY443 |
B | ASP444 |
B | GLY445 |
B | SER446 |
B | ASN471 |
B | GLY473 |
B | TYR474 |
B | THR475 |
B | ILE476 |
B | GLU477 |
B | MG601 |
B | ALK602 |
B | HOH2212 |
B | HOH2214 |
B | HOH2300 |
site_id | AC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG B 601 |
Chain | Residue |
B | ASP444 |
B | ASN471 |
B | GLY473 |
B | TPP600 |
B | HOH2300 |
site_id | AC8 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE ALK B 602 |
Chain | Residue |
A | GLY27 |
A | ASP28 |
A | HIS114 |
A | HIS115 |
A | HOH2014 |
B | PHE292 |
B | THR388 |
B | GLU477 |
B | ILE480 |
B | TPP600 |
site_id | AC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE ALK B 603 |
Chain | Residue |
B | SER311 |
B | HOH2161 |
B | HIS92 |
B | CYS221 |
B | HIS225 |
B | GLY286 |
B | ALA287 |
B | HIS310 |
site_id | BC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ALU B 604 |
Chain | Residue |
B | VAL17 |
B | LYS65 |
B | TYR157 |
site_id | BC2 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE TPP C 600 |
Chain | Residue |
C | THR390 |
C | GLY413 |
C | SER414 |
C | ILE415 |
C | GLY443 |
C | ASP444 |
C | GLY445 |
C | SER446 |
C | ASN471 |
C | GLY473 |
C | TYR474 |
C | THR475 |
C | ILE476 |
C | GLU477 |
C | MG601 |
C | ALK602 |
C | HOH2164 |
C | HOH2219 |
C | HOH2220 |
D | PRO26 |
D | GLY27 |
D | GLU51 |
D | VAL76 |
D | HIS115 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG C 601 |
Chain | Residue |
C | ASP444 |
C | ASN471 |
C | GLY473 |
C | TPP600 |
C | HOH2220 |
site_id | BC4 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE ALK C 602 |
Chain | Residue |
C | PHE292 |
C | THR388 |
C | GLU477 |
C | ILE480 |
C | TPP600 |
D | GLY27 |
D | ASP28 |
D | HIS114 |
D | HIS115 |
D | HOH2022 |
site_id | BC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE ALK C 603 |
Chain | Residue |
C | HIS92 |
C | CYS221 |
C | HIS225 |
C | GLY286 |
C | ALA287 |
C | HIS310 |
C | SER311 |
C | HOH2126 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ALU C 604 |
Chain | Residue |
C | GLN16 |
C | VAL17 |
C | GLU18 |
C | LYS65 |
C | TYR157 |
site_id | BC7 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE TPP D 600 |
Chain | Residue |
C | PRO26 |
C | GLY27 |
C | GLU51 |
C | VAL76 |
C | HIS115 |
D | THR390 |
D | GLY413 |
D | SER414 |
D | ILE415 |
D | GLY443 |
D | ASP444 |
D | GLY445 |
D | SER446 |
D | ASN471 |
D | GLY473 |
D | TYR474 |
D | THR475 |
D | ILE476 |
D | GLU477 |
D | MG601 |
D | ALK602 |
D | HOH2164 |
D | HOH2184 |
D | HOH2227 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG D 601 |
Chain | Residue |
D | ASP444 |
D | ASN471 |
D | GLY473 |
D | TPP600 |
D | HOH2184 |
site_id | BC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE ALK D 602 |
Chain | Residue |
C | GLY27 |
C | ASP28 |
C | HIS114 |
C | HIS115 |
D | THR388 |
D | GLU477 |
D | ILE480 |
D | TPP600 |
site_id | CC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE ALK D 603 |
Chain | Residue |
D | HIS92 |
D | CYS221 |
D | HIS225 |
D | GLY286 |
D | ALA287 |
D | HIS310 |
D | SER311 |
D | HOH2228 |
Functional Information from PROSITE/UniProt
site_id | PS00187 |
Number of Residues | 20 |
Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. FAaeeidPkkrvIlFiGDGS |
Chain | Residue | Details |
A | PHE427-SER446 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 36 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P06169 |
Chain | Residue | Details |
A | GLU477 | |
B | ASP28 | |
B | HIS115 | |
B | THR390 | |
B | GLY413 | |
B | ASP444 | |
B | GLY445 | |
B | ASN471 | |
B | GLY473 | |
B | GLU477 | |
C | ASP28 | |
C | HIS115 | |
C | THR390 | |
C | GLY413 | |
C | ASP444 | |
C | GLY445 | |
C | ASN471 | |
C | GLY473 | |
C | GLU477 | |
D | ASP28 | |
D | HIS115 | |
D | THR390 | |
D | GLY413 | |
D | ASP444 | |
D | GLY445 | |
D | ASN471 | |
D | GLY473 | |
D | GLU477 | |
A | ASP28 | |
A | HIS115 | |
A | THR390 | |
A | GLY413 | |
A | ASP444 | |
A | GLY445 | |
A | ASN471 | |
A | GLY473 |