2VJA
Torpedo Californica Acetylcholinesterase In Complex With A Non Hydrolysable Substrate Analogue, 4-Oxo-N,N,N- Trimethylpentanaminium - Orthorhombic space group - Dataset A at 100K
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001507 | biological_process | acetylcholine catabolic process in synaptic cleft |
| A | 0003990 | molecular_function | acetylcholinesterase activity |
| A | 0004104 | molecular_function | cholinesterase activity |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006581 | biological_process | acetylcholine catabolic process |
| A | 0019695 | biological_process | choline metabolic process |
| A | 0043083 | cellular_component | synaptic cleft |
| A | 0045202 | cellular_component | synapse |
| A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| A | 0098552 | cellular_component | side of membrane |
| B | 0001507 | biological_process | acetylcholine catabolic process in synaptic cleft |
| B | 0003990 | molecular_function | acetylcholinesterase activity |
| B | 0004104 | molecular_function | cholinesterase activity |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006581 | biological_process | acetylcholine catabolic process |
| B | 0019695 | biological_process | choline metabolic process |
| B | 0043083 | cellular_component | synaptic cleft |
| B | 0045202 | cellular_component | synapse |
| B | 0052689 | molecular_function | carboxylic ester hydrolase activity |
| B | 0098552 | cellular_component | side of membrane |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Acyl-ester intermediate |
| Chain | Residue | Details |
| A | SER200 | |
| B | SER200 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | GLU327 | |
| A | HIS440 | |
| B | GLU327 | |
| B | HIS440 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299, ECO:0000269|PubMed:16763558 |
| Chain | Residue | Details |
| A | ASN59 | |
| B | ASN59 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299, ECO:0000269|PubMed:16763558, ECO:0000269|PubMed:1678899 |
| Chain | Residue | Details |
| A | ASN416 | |
| B | ASN416 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10368299 |
| Chain | Residue | Details |
| A | ASN457 | |
| A | ASN533 | |
| B | ASN457 | |
| B | ASN533 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qe3 |
| Chain | Residue | Details |
| A | SER200 | |
| A | HIS440 | |
| A | GLU327 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qe3 |
| Chain | Residue | Details |
| B | SER200 | |
| B | HIS440 | |
| B | GLU327 |
