2VIK

REFINED STRUCTURE OF THE ACTIN-SEVERING DOMAIN VILLIN 14T, DETERMINED BY SOLUTION NMR, MINIMIZED AVERAGE STRUCTURE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0051015	molecular_function	actin filament binding

Functional Information from PDB Data

site_id	ACT
Number of Residues	1
Details	CENTER OF ACTIN MONOMER BINDING SITE, BASED ON COMPARISON WITH THE GELSOLIN SEGMENT 1-ACTIN COCRYSTAL (CENTERED ON ILE 79).

Chain	Residue
A	ILE79

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site_id	CA1
Number of Residues	2
Details	SIDE CHAINS THAT PROVIDE LIGANDS TO CALCIUM IN THE STRONGER BINDING SITE, BASED ON COMPARISON TO GELSOLIN SEGMENT 1 AND CALCIUM TITRATIONS MONITORED BY NMR. NOTE THIS CORRESPONDS TO THE INTRAMOLECULAR SITE IN THE GELSOLIN SEGMENT 1-ACTIN CO-CRYSTAL (ASP 43, GLU 73).

Chain	Residue
A	ASP43
A	GLU73

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site_id	CA2
Number of Residues	1
Details	SIDE CHAIN THAT PROVIDES LIGANDS TO CALCIUM IN THE WEAKER BINDING SITE, BASED ON COMPARISON TO GELSOLIN SEGMENT 1 AND CALCIUM TITRATIONS MONITORED BY NMR. NOTE THIS CORRESPONDS TO THE INTERMOLECULAR SITE IN THE GELSOLIN SEGMENT 1-ACTIN CO-CRYSTAL (ASP 85).

Chain	Residue
A	ASP85

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	49
Details	Repeat: {"description":"Gelsolin-like 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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