Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2VIG

Crystal structure of human short-chain acyl CoA dehydrogenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003995	molecular_function	acyl-CoA dehydrogenase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006635	biological_process	fatty acid beta-oxidation
A	0016491	molecular_function	oxidoreductase activity
A	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
A	0016937	molecular_function	short-chain fatty acyl-CoA dehydrogenase activity
A	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A	0046359	biological_process	butyrate catabolic process
A	0050660	molecular_function	flavin adenine dinucleotide binding
B	0003995	molecular_function	acyl-CoA dehydrogenase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006635	biological_process	fatty acid beta-oxidation
B	0016491	molecular_function	oxidoreductase activity
B	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
B	0016937	molecular_function	short-chain fatty acyl-CoA dehydrogenase activity
B	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B	0046359	biological_process	butyrate catabolic process
B	0050660	molecular_function	flavin adenine dinucleotide binding
C	0003995	molecular_function	acyl-CoA dehydrogenase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006635	biological_process	fatty acid beta-oxidation
C	0016491	molecular_function	oxidoreductase activity
C	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
C	0016937	molecular_function	short-chain fatty acyl-CoA dehydrogenase activity
C	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C	0046359	biological_process	butyrate catabolic process
C	0050660	molecular_function	flavin adenine dinucleotide binding
D	0003995	molecular_function	acyl-CoA dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006635	biological_process	fatty acid beta-oxidation
D	0016491	molecular_function	oxidoreductase activity
D	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
D	0016937	molecular_function	short-chain fatty acyl-CoA dehydrogenase activity
D	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D	0046359	biological_process	butyrate catabolic process
D	0050660	molecular_function	flavin adenine dinucleotide binding
E	0003995	molecular_function	acyl-CoA dehydrogenase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0006635	biological_process	fatty acid beta-oxidation
E	0016491	molecular_function	oxidoreductase activity
E	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
E	0016937	molecular_function	short-chain fatty acyl-CoA dehydrogenase activity
E	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E	0046359	biological_process	butyrate catabolic process
E	0050660	molecular_function	flavin adenine dinucleotide binding
F	0003995	molecular_function	acyl-CoA dehydrogenase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006629	biological_process	lipid metabolic process
F	0006631	biological_process	fatty acid metabolic process
F	0006635	biological_process	fatty acid beta-oxidation
F	0016491	molecular_function	oxidoreductase activity
F	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
F	0016937	molecular_function	short-chain fatty acyl-CoA dehydrogenase activity
F	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F	0046359	biological_process	butyrate catabolic process
F	0050660	molecular_function	flavin adenine dinucleotide binding
G	0003995	molecular_function	acyl-CoA dehydrogenase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0006629	biological_process	lipid metabolic process
G	0006631	biological_process	fatty acid metabolic process
G	0006635	biological_process	fatty acid beta-oxidation
G	0016491	molecular_function	oxidoreductase activity
G	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
G	0016937	molecular_function	short-chain fatty acyl-CoA dehydrogenase activity
G	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G	0046359	biological_process	butyrate catabolic process
G	0050660	molecular_function	flavin adenine dinucleotide binding
H	0003995	molecular_function	acyl-CoA dehydrogenase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0006629	biological_process	lipid metabolic process
H	0006631	biological_process	fatty acid metabolic process
H	0006635	biological_process	fatty acid beta-oxidation
H	0016491	molecular_function	oxidoreductase activity
H	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
H	0016937	molecular_function	short-chain fatty acyl-CoA dehydrogenase activity
H	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
H	0046359	biological_process	butyrate catabolic process
H	0050660	molecular_function	flavin adenine dinucleotide binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	29
Details	BINDING SITE FOR RESIDUE FAD A 600

Chain	Residue
A	PHE152
A	TYR391
A	GLU392
A	THR394
A	GLU396
A	LEU400
A	HOH711
A	HOH630
A	HOH683
A	HOH633
A	HOH639
A	LEU154
A	HOH669
B	ARG297
B	PHE300
B	LEU304
B	LEU307
B	GLN365
B	ILE366
B	GLY369
B	HOH608
C	GLN308
A	SER155
A	GLY160
A	SER161
A	TRP185
A	THR187
A	LYS230
A	ILE387

site_id	AC2
Number of Residues	29
Details	BINDING SITE FOR RESIDUE FAD B 600

Chain	Residue
A	ARG297
A	PHE300
A	LEU304
A	LEU307
A	GLN365
A	ILE366
A	GLY369
A	HOH603
B	PHE152
B	LEU154
B	SER155
B	GLY160
B	SER161
B	TRP185
B	THR187
B	LYS230
B	ILE387
B	ILE390
B	TYR391
B	GLU392
B	THR394
B	GLU396
B	COS502
B	HOH676
B	HOH634
B	HOH681
B	HOH675
B	HOH669
D	GLN308

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE COS B 605

Chain	Residue
A	PHE300
B	GLY160
B	SER161
B	PHE261
B	MET265
B	GLN266
B	LEU268
B	ASP269
B	ARG272
B	ILE342
B	GLU392
B	GLY393
B	ILE397
B	FAD501
B	HOH656
B	HOH646
B	HOH631

site_id	AC4
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAD C 600

Chain	Residue
D	PHE300
D	LEU304
D	LEU307
D	GLN365
D	ILE366
D	GLY369
D	HOH650
A	GLN308
C	PHE152
C	LEU154
C	SER155
C	GLY160
C	SER161
C	TRP185
C	THR187
C	LYS230
C	ILE387
C	ILE390
C	TYR391
C	GLU392
C	THR394
C	GLU396
C	LEU400
C	COS502
C	HOH653
C	HOH649
C	HOH625
C	HOH633
C	HOH651
C	HOH671
D	ARG297

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE COS C 605

Chain	Residue
C	SER155
C	GLY160
C	SER161
C	LEU268
C	ARG272
C	GLU392
C	GLY393
C	ILE397
C	FAD501

site_id	AC6
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAD D 600

Chain	Residue
B	GLN308
C	ARG297
C	PHE300
C	LEU304
C	LEU307
C	VAL309
C	GLN365
C	ILE366
C	GLY369
C	HOH604
D	PHE152
D	LEU154
D	SER155
D	GLY160
D	SER161
D	TRP185
D	ILE186
D	THR187
D	LYS230
D	ILE387
D	TYR391
D	GLU392
D	THR394
D	GLU396
D	LEU400
D	COS502
D	HOH652
D	HOH645
D	HOH671
D	HOH657
D	HOH619

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE COS D 605

Chain	Residue
D	SER155
D	GLY160
D	SER161
D	LEU268
D	ARG272
D	GLU392
D	GLY393
D	FAD501

site_id	AC8
Number of Residues	30
Details	BINDING SITE FOR RESIDUE FAD E 600

Chain	Residue
E	PHE152
E	LEU154
E	SER155
E	GLY160
E	SER161
E	TRP185
E	THR187
E	LYS230
E	ILE390
E	TYR391
E	GLU392
E	THR394
E	GLU396
E	LEU400
E	HOH685
E	HOH688
E	HOH616
E	HOH646
E	HOH707
E	HOH655
F	ARG297
F	PHE300
F	LEU304
F	LEU307
F	VAL309
F	GLN365
F	ILE366
F	GLY369
F	HOH604
G	GLN308

site_id	AC9
Number of Residues	28
Details	BINDING SITE FOR RESIDUE FAD F 600

Chain	Residue
E	ARG297
E	PHE300
E	LEU304
E	LEU307
E	VAL309
E	GLN365
E	ILE366
E	GLY369
E	HOH613
F	PHE152
F	LEU154
F	SER155
F	GLY160
F	SER161
F	TRP185
F	THR187
F	LYS230
F	TYR391
F	GLU392
F	THR394
F	GLU396
F	COS502
F	HOH654
F	HOH656
F	HOH647
F	HOH652
F	HOH630
H	GLN308

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE COS F 605

Chain	Residue
F	SER155
F	GLY160
F	SER161
F	LEU268
F	ARG272
F	GLU392
F	GLY393
F	FAD501
F	HOH610

site_id	BC2
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAD G 600

Chain	Residue
E	GLN308
G	PHE152
G	LEU154
G	SER155
G	GLY160
G	SER161
G	TRP185
G	ILE186
G	THR187
G	LYS230
G	ILE387
G	ILE390
G	TYR391
G	GLU392
G	THR394
G	GLU396
G	LEU400
G	COS502
G	HOH637
G	HOH662
G	HOH689
G	HOH674
G	HOH630
H	ARG297
H	PHE300
H	LEU304
H	LEU307
H	GLN365
H	ILE366
H	GLY369
H	HOH644

site_id	BC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE COS G 605

Chain	Residue
G	GLY160
G	SER161
G	ALA163
G	ASN207
G	PHE261
G	MET265
G	GLN266
G	LEU268
G	ASP269
G	ARG272
G	ILE342
G	GLU392
G	GLY393
G	VAL401
G	FAD501
G	HOH672
G	HOH642
G	HOH601
G	HOH660
H	PHE300

site_id	BC4
Number of Residues	29
Details	BINDING SITE FOR RESIDUE FAD H 600

Chain	Residue
F	GLN308
G	ARG297
G	PHE300
G	LEU307
G	GLN365
G	ILE366
G	GLY369
G	HOH611
H	PHE152
H	LEU154
H	SER155
H	GLY160
H	SER161
H	TRP185
H	ILE186
H	THR187
H	LYS230
H	ILE387
H	ILE390
H	TYR391
H	GLU392
H	THR394
H	GLU396
H	LEU400
H	HOH669
H	HOH695
H	HOH647
H	HOH614
H	HOH610

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO F1414

Chain	Residue
F	GLN59
F	PRO67
F	GLN70
F	HOH699
F	HOH704

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO D1414

Chain	Residue
D	PRO67
D	GLN70

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO E1414

Chain	Residue
E	LEU65
E	PRO67
E	GLN70
E	HOH680

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO H1414

Chain	Residue
H	GLN59
H	LEU65
H	PRO67
H	GLN70
H	HOH635

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B1412

Chain	Residue
B	GLN59
B	PRO67
B	GLN70

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D1415

Chain	Residue
B	ARG330
D	GLU322
D	ARG325
D	LEU326
D	HOH702

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A1413

Chain	Residue
A	GLU322
A	ARG325
A	LEU326
C	ARG330

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E1415

Chain	Residue
E	GLU322
E	ARG325
E	LEU326
G	ARG330
E	HOH633
E	HOH700

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO H1415

Chain	Residue
F	ARG330
H	GLU322
H	ARG325
H	LEU326
H	HOH700

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO E1416

Chain	Residue
E	GLU156
E	PRO157
E	SER167
E	GLY181
E	THR182
E	HOH706
E	HOH689

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO F1415

Chain	Residue
D	GLU134
F	GLU134
F	GLN135
F	TRP139
F	HOH702

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO F1416

Chain	Residue
F	GLU156
F	SER167
F	THR168
F	GLY181
F	THR182
F	HOH693

Functional Information from PROSITE/UniProt

site_id	PS00072
Number of Residues	13
Details	ACYL_COA_DH_1 Acyl-CoA dehydrogenases signature 1. ALSEpgNGSDagA

Chain	Residue	Details
A	ALA153-ALA165

site_id	PS00073
Number of Residues	20
Details	ACYL_COA_DH_2 Acyl-CoA dehydrogenases signature 2. QiLGGmGYvtEmpaeRhyrD

Chain	Residue	Details
A	GLN365-ASP384

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P15651","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	112
Details	Binding site: {"description":"in other chain","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human RAB14.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	40
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human RAB14.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	32
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q07417","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	13
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q07417","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
A	GLY271

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
B	GLU392

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
C	GLU392

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
D	GLU392

site_id	CSA13
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
E	GLU392

site_id	CSA14
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
F	GLU392

site_id	CSA15
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
G	GLU392

site_id	CSA16
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
H	GLU392

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
B	GLY271

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
C	GLY271

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
D	GLY271

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
E	GLY271

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
F	GLY271

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
G	GLY271

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
H	GLY271

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1ivh

Chain	Residue	Details
A	GLU392

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)