2VGW
Crystal structure of E53QbsSHMT obtained in the presence of glycine and 5-fomyl tetrahydrofolate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006545 | biological_process | glycine biosynthetic process |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019264 | biological_process | glycine biosynthetic process from serine |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| A | 0046653 | biological_process | tetrahydrofolate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE PLP A1407 |
| Chain | Residue |
| A | TYR51 |
| A | ALA199 |
| A | HIS200 |
| A | THR223 |
| A | HIS225 |
| A | LYS226 |
| A | GLY256 |
| A | GLY257 |
| A | GLY1408 |
| A | HOH2281 |
| A | HOH2282 |
| A | GLN53 |
| A | HOH2283 |
| A | HOH2284 |
| A | SER93 |
| A | GLY94 |
| A | ALA95 |
| A | HIS122 |
| A | ALA171 |
| A | SER172 |
| A | ASP197 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GLY A1408 |
| Chain | Residue |
| A | SER31 |
| A | TYR51 |
| A | TYR61 |
| A | SER172 |
| A | HIS200 |
| A | LYS226 |
| A | ARG357 |
| A | PLP1407 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD A1409 |
| Chain | Residue |
| A | TYR152 |
| A | ARG156 |
| A | GLU185 |
| A | LEU322 |
| A | HOH2285 |
| A | HOH2286 |
| A | HOH2287 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PO4 A1410 |
| Chain | Residue |
| A | HOH2288 |
Functional Information from PROSITE/UniProt
| site_id | PS00096 |
| Number of Residues | 17 |
| Details | SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. HFvTTTTHKTLrGPRGG |
| Chain | Residue | Details |
| A | HIS218-GLY234 |
