Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2VG2

Rv2361 with IPP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004659	molecular_function	prenyltransferase activity
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0008834	molecular_function	ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity
A	0016094	biological_process	polyprenol biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0030145	molecular_function	manganese ion binding
A	0033850	molecular_function	Z-farnesyl diphosphate synthase activity
A	0045547	molecular_function	ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity
A	0046872	molecular_function	metal ion binding
A	0052923	molecular_function	all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity
B	0000287	molecular_function	magnesium ion binding
B	0004659	molecular_function	prenyltransferase activity
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0008834	molecular_function	ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity
B	0016094	biological_process	polyprenol biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0030145	molecular_function	manganese ion binding
B	0033850	molecular_function	Z-farnesyl diphosphate synthase activity
B	0045547	molecular_function	ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity
B	0046872	molecular_function	metal ion binding
B	0052923	molecular_function	all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity
C	0000287	molecular_function	magnesium ion binding
C	0004659	molecular_function	prenyltransferase activity
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0008834	molecular_function	ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity
C	0016094	biological_process	polyprenol biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0030145	molecular_function	manganese ion binding
C	0033850	molecular_function	Z-farnesyl diphosphate synthase activity
C	0045547	molecular_function	ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity
C	0046872	molecular_function	metal ion binding
C	0052923	molecular_function	all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity
D	0000287	molecular_function	magnesium ion binding
D	0004659	molecular_function	prenyltransferase activity
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0008834	molecular_function	ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity
D	0016094	biological_process	polyprenol biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0030145	molecular_function	manganese ion binding
D	0033850	molecular_function	Z-farnesyl diphosphate synthase activity
D	0045547	molecular_function	ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity
D	0046872	molecular_function	metal ion binding
D	0052923	molecular_function	all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE DPO A1297

Chain	Residue
A	MET75
A	IPE1298
C	ARG292
C	ALA296
A	ASP76
A	GLY77
A	ASN78
A	GLY79
A	ARG80
A	ARG89
A	HIS93
A	ARG127

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE DPO B1296

Chain	Residue
B	MET75
B	ASP76
B	GLY77
B	ASN78
B	GLY79
B	ARG80
B	ARG89
B	HIS93
B	ARG127
B	IPE1297
B	HOH2176
D	ARG292

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE DPO C1297

Chain	Residue
C	MET75
C	ASP76
C	GLY77
C	ASN78
C	GLY79
C	ARG80
C	ARG89
C	HIS93
C	ARG127
C	GOL1301
C	HOH2176

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 C1298

Chain	Residue
C	SER121
C	GLU123
C	ASN124
C	SER252
C	HOH2177
C	HOH2178
C	HOH2179

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 D1297

Chain	Residue
D	ASP76
D	GLY77
D	ASN78
D	GLY79
D	ARG89
D	HIS93
D	ARG127
D	HOH2061
D	HOH2162

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE IPE A1298

Chain	Residue
A	VAL74
A	MET75
A	ASP76
A	TYR118
A	SER121
A	ASN124
A	ARG244
A	ARG250
A	SER252
A	DPO1297
A	HOH2225
A	HOH2226
C	TYR261
C	ARG292
C	PHE293
C	GLY294

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE IPE B1297

Chain	Residue
B	TYR118
B	ALA119
B	SER121
B	ASN124
B	ARG127
B	ARG244
B	ARG250
B	SER252
B	DPO1296
B	HOH2067
B	HOH2176
B	HOH2177
D	TYR261
D	ARG292
D	PHE293
D	GLY294

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL B1298

Chain	Residue
B	THR29
B	TRP32
B	PRO33
B	VAL34
B	LYS94
B	MET95
B	GLU97
B	ALA98
B	ARG146
B	HOH2015
B	HOH2054

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A1299

Chain	Residue
A	TRP125
A	PRO164
A	ARG165
A	HOH2227

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A1300

Chain	Residue
A	LYS126
A	ARG127
A	SER128
A	HOH2228
A	HOH2229
A	TRP125

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B1299

Chain	Residue
A	GOL1305
B	THR122
B	TRP125
B	ARG165
B	HOH2178

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B1300

Chain	Residue
B	LYS126
B	ARG127
B	SER128

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL C1299

Chain	Residue
C	ALA228
C	LEU231
C	ARG233
C	PRO234
C	ILE236
C	GLN258
C	GOL1300
C	HOH2180
C	HOH2181

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C1300

Chain	Residue
A	ARG198
C	ALA228
C	ASP238
C	TRP257
C	GOL1299
C	HOH2181
C	HOH2182

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C1301

Chain	Residue
C	MET75
C	ASN78
C	TYR118
C	ALA119
C	ASN124
C	DPO1297
C	HOH2177

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B1301

Chain	Residue
B	GLY294
B	SER295
B	HOH2179

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A1301

Chain	Residue
A	ALA64
A	LEU67
A	ASN69
A	HOH2062
A	HOH2230
B	PRO129
B	GLU130
B	HOH2076

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A1305

Chain	Residue
B	PRO164
B	GOL1299

site_id	CC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A1302

Chain	Residue
A	THR29
A	TRP32
A	PRO33
A	VAL34
A	LYS94
A	MET95
A	GLU97
A	ALA98
A	ARG146
A	HOH2077
A	HOH2231

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A1303

Chain	Residue
A	ARG66
A	THR290
A	ARG291
B	SER169

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 C1302

Chain	Residue
A	PRO20
A	ASP21
A	HOH2009
C	ARG168
C	HOH2183

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 A1304

Chain	Residue
A	ASP273
A	ASP275
A	ARG277

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 D1298

Chain	Residue
C	GLY215
D	LYS113
D	TRP114
D	ASP185
D	THR188
D	HOH2027

Functional Information from PROSITE/UniProt

site_id	PS01066
Number of Residues	18
Details	UPP_SYNTHASE Undecaprenyl pyrophosphate synthase family signature. DLFLRTSGeqRsSnFMLW

Chain	Residue	Details
A	ASP240-TRP257

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	60
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	20
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1f75

Chain	Residue	Details
A	ARG80
A	ARG244
A	ARG250
A	ARG89

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1f75

Chain	Residue	Details
B	ARG80
B	ARG244
B	ARG250
B	ARG89

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1f75

Chain	Residue	Details
C	ARG80
C	ARG244
C	ARG250
C	ARG89

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1f75

Chain	Residue	Details
D	ARG80
D	ARG244
D	ARG250
D	ARG89

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)