Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2VDK

Re-refinement of Integrin AlphaIIbBeta3 Headpiece

Replaces: 1TY3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007155	biological_process	cell adhesion
A	0008305	cellular_component	integrin complex
L	0002250	biological_process	adaptive immune response
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005886	cellular_component	plasma membrane
L	0030183	biological_process	B cell differentiation
L	0042105	cellular_component	alpha-beta T cell receptor complex
L	0071735	cellular_component	IgG immunoglobulin complex

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR192-HIS198

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	61
Details	Repeat: {"description":"FG-GAP 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	63
Details	Repeat: {"description":"FG-GAP 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	51
Details	Repeat: {"description":"FG-GAP 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	54
Details	Repeat: {"description":"FG-GAP 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	65
Details	Repeat: {"description":"FG-GAP 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	59
Details	Repeat: {"description":"FG-GAP 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00803","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2775232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2775232","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	46
Details	Domain: {"description":"PSI","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	242
Details	Domain: {"description":"VWFA","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	7
Details	Region: {"description":"Involved in CX3CL1-, NRG1-, FGF1- and IGF1-binding","evidences":[{"source":"PubMed","id":"18441324","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19578119","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20682778","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23125415","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	20
Details	Region: {"description":"CX3CL1-binding","evidences":[{"source":"PubMed","id":"24789099","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Binding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Binding site: {"description":"in MIDAS binding site","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	2
Details	Binding site: {"description":"in ADMIDAS binding site","evidences":[{"source":"PubMed","id":"11546839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	4
Details	Binding site: {"description":"in LIMBS binding site","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	1
Details	Binding site: {"description":"in LIMBS binding site","evidences":[{"source":"PDB","id":"4G1M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Binding site: {"description":"in ADMIDAS binding site and unliganded-closed conformation","evidences":[{"source":"PubMed","id":"11546839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FCS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11546839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15378069","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19111664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19704023","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IJE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)