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2VDD

Crystal Structure of the Open State of TolC Outer Membrane Component of Mutlidrug Efflux Pumps

Functional Information from GO Data
ChainGOidnamespacecontents
A0015562molecular_functionefflux transmembrane transporter activity
A0019867cellular_componentouter membrane
A0055085biological_processtransmembrane transport
B0015562molecular_functionefflux transmembrane transporter activity
B0019867cellular_componentouter membrane
B0055085biological_processtransmembrane transport
C0015562molecular_functionefflux transmembrane transporter activity
C0019867cellular_componentouter membrane
C0055085biological_processtransmembrane transport
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL B1454
ChainResidue
BGLN316
BGLY318
BMET319
BVAL320
BASN321

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL A1454
ChainResidue
AASN321
AGLN316
AGLY318
AMET319
AVAL320

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL C1454
ChainResidue
CGLN316
CGLY318
CMET319
CVAL320

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues630
DetailsTOPO_DOM: Periplasmic
ChainResidueDetails
AGLU23-PRO62
AILE97-PRO268
BGLU23-PRO62
BILE97-PRO268
CGLU23-PRO62
CILE97-PRO268

site_idSWS_FT_FI2
Number of Residues33
DetailsTRANSMEM: Beta stranded; Name=S1
ChainResidueDetails
AGLN63-ASN74
BGLN63-ASN74
CGLN63-ASN74

site_idSWS_FT_FI3
Number of Residues81
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
AGLY75-ILE82
AASP280-ASN300
BGLY75-ILE82
BASP280-ASN300
CGLY75-ILE82
CASP280-ASN300

site_idSWS_FT_FI4
Number of Residues39
DetailsTRANSMEM: Beta stranded; Name=S2
ChainResidueDetails
AASN83-SER96
BASN83-SER96
CASN83-SER96

site_idSWS_FT_FI5
Number of Residues30
DetailsTRANSMEM: Beta stranded; Name=S4
ChainResidueDetails
ATHR269-SER279
BTHR269-SER279
CTHR269-SER279

site_idSWS_FT_FI6
Number of Residues30
DetailsTRANSMEM: Beta stranded; Name=S5
ChainResidueDetails
AMET301-SER311
BMET301-SER311
CMET301-SER311

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PDB entries from 2024-11-06

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