Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2VCV

Glutathione transferase A3-3 in complex with glutathione and delta-4- androstene-3-17-dione

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0016740	molecular_function	transferase activity
A	0070062	cellular_component	extracellular exosome
B	0004364	molecular_function	glutathione transferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006749	biological_process	glutathione metabolic process
B	0006805	biological_process	xenobiotic metabolic process
B	0016740	molecular_function	transferase activity
B	0070062	cellular_component	extracellular exosome
C	0004364	molecular_function	glutathione transferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006749	biological_process	glutathione metabolic process
C	0006805	biological_process	xenobiotic metabolic process
C	0016740	molecular_function	transferase activity
C	0070062	cellular_component	extracellular exosome
D	0004364	molecular_function	glutathione transferase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0006749	biological_process	glutathione metabolic process
D	0006805	biological_process	xenobiotic metabolic process
D	0016740	molecular_function	transferase activity
D	0070062	cellular_component	extracellular exosome
E	0004364	molecular_function	glutathione transferase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006629	biological_process	lipid metabolic process
E	0006749	biological_process	glutathione metabolic process
E	0006805	biological_process	xenobiotic metabolic process
E	0016740	molecular_function	transferase activity
E	0070062	cellular_component	extracellular exosome
F	0004364	molecular_function	glutathione transferase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006629	biological_process	lipid metabolic process
F	0006749	biological_process	glutathione metabolic process
F	0006805	biological_process	xenobiotic metabolic process
F	0016740	molecular_function	transferase activity
F	0070062	cellular_component	extracellular exosome
G	0004364	molecular_function	glutathione transferase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006629	biological_process	lipid metabolic process
G	0006749	biological_process	glutathione metabolic process
G	0006805	biological_process	xenobiotic metabolic process
G	0016740	molecular_function	transferase activity
G	0070062	cellular_component	extracellular exosome
H	0004364	molecular_function	glutathione transferase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006629	biological_process	lipid metabolic process
H	0006749	biological_process	glutathione metabolic process
H	0006805	biological_process	xenobiotic metabolic process
H	0016740	molecular_function	transferase activity
H	0070062	cellular_component	extracellular exosome
I	0004364	molecular_function	glutathione transferase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006629	biological_process	lipid metabolic process
I	0006749	biological_process	glutathione metabolic process
I	0006805	biological_process	xenobiotic metabolic process
I	0016740	molecular_function	transferase activity
I	0070062	cellular_component	extracellular exosome
J	0004364	molecular_function	glutathione transferase activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006629	biological_process	lipid metabolic process
J	0006749	biological_process	glutathione metabolic process
J	0006805	biological_process	xenobiotic metabolic process
J	0016740	molecular_function	transferase activity
J	0070062	cellular_component	extracellular exosome
K	0004364	molecular_function	glutathione transferase activity
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006629	biological_process	lipid metabolic process
K	0006749	biological_process	glutathione metabolic process
K	0006805	biological_process	xenobiotic metabolic process
K	0016740	molecular_function	transferase activity
K	0070062	cellular_component	extracellular exosome
L	0004364	molecular_function	glutathione transferase activity
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006629	biological_process	lipid metabolic process
L	0006749	biological_process	glutathione metabolic process
L	0006805	biological_process	xenobiotic metabolic process
L	0016740	molecular_function	transferase activity
L	0070062	cellular_component	extracellular exosome
M	0004364	molecular_function	glutathione transferase activity
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006629	biological_process	lipid metabolic process
M	0006749	biological_process	glutathione metabolic process
M	0006805	biological_process	xenobiotic metabolic process
M	0016740	molecular_function	transferase activity
M	0070062	cellular_component	extracellular exosome
N	0004364	molecular_function	glutathione transferase activity
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006629	biological_process	lipid metabolic process
N	0006749	biological_process	glutathione metabolic process
N	0006805	biological_process	xenobiotic metabolic process
N	0016740	molecular_function	transferase activity
N	0070062	cellular_component	extracellular exosome
O	0004364	molecular_function	glutathione transferase activity
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006629	biological_process	lipid metabolic process
O	0006749	biological_process	glutathione metabolic process
O	0006805	biological_process	xenobiotic metabolic process
O	0016740	molecular_function	transferase activity
O	0070062	cellular_component	extracellular exosome
P	0004364	molecular_function	glutathione transferase activity
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006629	biological_process	lipid metabolic process
P	0006749	biological_process	glutathione metabolic process
P	0006805	biological_process	xenobiotic metabolic process
P	0016740	molecular_function	transferase activity
P	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GSH A 1223

Chain	Residue
A	TYR9
A	ASD1224
A	HOH2207
B	ASP101
B	ARG131
A	ARG15
A	ARG45
A	GLN54
A	VAL55
A	PRO56
A	GLN67
A	THR68
A	PHE220

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ASD A 1224

Chain	Residue
A	PHE10
A	PRO110
A	ALA208
A	ALA212
A	LEU213
A	ALA216
A	GSH1223

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GSH B 1223

Chain	Residue
A	ASP101
A	ARG131
A	HOH2111
B	TYR9
B	GLN54
B	VAL55
B	PRO56
B	GLN67
B	THR68
B	ASD1224
B	HOH2067
B	HOH2214

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ASD B 1224

Chain	Residue
B	PHE10
B	PRO110
B	ALA208
B	LEU213
B	ALA216
B	GSH1223
B	HOH2215

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GSH C 1223

Chain	Residue
C	TYR9
C	ARG15
C	ARG45
C	GLN54
C	VAL55
C	GLN67
C	THR68
C	HOH2171
D	ASP101
D	ARG131
D	HOH2085

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GSH D 1223

Chain	Residue
C	ASP101
C	ARG131
D	TYR9
D	ARG15
D	ARG45
D	GLN54
D	VAL55
D	PRO56
D	GLN67
D	THR68
D	PHE220
D	ASD1224
D	HOH2053
D	HOH2179

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ASD D 1224

Chain	Residue
D	PHE10
D	LEU107
D	PRO110
D	ALA208
D	LEU213
D	GSH1223

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GSH E 1223

Chain	Residue
E	TYR9
E	ARG15
E	ARG45
E	GLN54
E	VAL55
E	GLN67
E	THR68
E	PHE220
E	ASD1224
E	HOH2063
F	ASP101
F	ARG131

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ASD E 1224

Chain	Residue
E	PHE10
E	PRO110
E	ALA208
E	LEU213
E	ALA216
E	PHE222
E	GSH1223

site_id	BC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GSH F 1223

Chain	Residue
F	ASD1224
F	HOH2214
F	HOH2215
E	ASP101
E	ARG131
F	TYR9
F	ARG45
F	GLN54
F	VAL55
F	PRO56
F	GLN67
F	THR68
F	PHE220

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ASD F 1224

Chain	Residue
F	PHE10
F	PRO110
F	ALA208
F	GSH1223

site_id	BC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GSH G 1223

Chain	Residue
G	TYR9
G	ARG15
G	ARG45
G	GLN54
G	VAL55
G	PRO56
G	GLN67
G	THR68
G	PHE220
G	ASD1224
G	HOH2228
G	HOH2229
H	ASP101
H	ARG131
H	HOH2101

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ASD G 1224

Chain	Residue
G	PHE10
G	PRO110
G	ALA208
G	GSH1223
G	HOH2230

site_id	BC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GSH H 1223

Chain	Residue
G	ASP101
G	ARG131
H	TYR9
H	ARG15
H	ARG45
H	GLN54
H	VAL55
H	GLN67
H	THR68
H	ASD1224
H	HOH2194

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ASD H 1224

Chain	Residue
H	PHE10
H	PRO110
H	ALA208
H	LEU213
H	PHE222
H	GSH1223

site_id	BC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GSH I 1223

Chain	Residue
I	TYR9
I	ARG15
I	ARG45
I	GLN54
I	VAL55
I	GLN67
I	THR68
I	PHE220
I	ASD1224
I	HOH2071
J	ASP101
J	ARG131

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ASD I 1224

Chain	Residue
I	PHE10
I	PRO110
I	ALA208
I	LEU213
I	ALA216
I	GSH1223

site_id	BC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GSH J 1223

Chain	Residue
I	ASP101
I	ARG131
J	TYR9
J	ARG15
J	ARG45
J	GLN54
J	VAL55
J	GLN67
J	THR68
J	HOH2186
J	HOH2187

site_id	CC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GSH K 1223

Chain	Residue
K	TYR9
K	ARG15
K	ARG45
K	GLN54
K	VAL55
K	GLN67
K	THR68
K	PHE220
K	ASD1224
K	HOH2061
K	HOH2074
L	ASP101
L	ARG131

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ASD K 1224

Chain	Residue
K	PHE10
K	LEU107
K	PRO110
K	ALA208
K	LEU213
K	ALA216
K	GSH1223

site_id	CC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GSH L 1223

Chain	Residue
K	ASP101
K	ARG131
K	HOH2112
L	TYR9
L	ARG45
L	GLN54
L	VAL55
L	PRO56
L	GLN67
L	THR68
L	ASD1224
L	HOH2226
L	HOH2227

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ASD L 1224

Chain	Residue
L	PHE10
L	PRO110
L	ALA208
L	ALA216
L	PHE222
L	GSH1223
L	HOH2228

site_id	CC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GSH M 1223

Chain	Residue
M	TYR9
M	ARG15
M	ARG45
M	GLN54
M	VAL55
M	GLN67
M	THR68
M	PHE220
M	HOH2224
N	ASP101
N	ARG131

site_id	CC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GSH N 1223

Chain	Residue
M	ASP101
M	ARG131
N	TYR9
N	ARG15
N	ARG45
N	GLN54
N	VAL55
N	PRO56
N	GLN67
N	THR68
N	HOH2011
N	HOH2213

site_id	CC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GSH O 1223

Chain	Residue
O	TYR9
O	ARG45
O	GLN54
O	VAL55
O	GLN67
O	THR68
O	PHE220
O	HOH2198
O	HOH2199
P	ASP101
P	ARG131

site_id	CC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GSH P 1223

Chain	Residue
O	ASP101
O	ARG131
P	TYR9
P	ARG15
P	ARG45
P	GLN54
P	VAL55
P	GLN67
P	THR68
P	PHE220
P	ASD1224

site_id	CC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ASD P 1224

Chain	Residue
P	PHE10
P	PRO110
P	ALA208
P	LEU213
P	ALA216
P	PHE220
P	GSH1223

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	BINDING: BINDING => ECO:0000269\|PubMed:15595823, ECO:0000269\|PubMed:20083122

Chain	Residue	Details
A	TYR9
C	ARG45
C	GLN54
C	GLN67
D	TYR9
D	ARG45
D	GLN54
D	GLN67
E	TYR9
E	ARG45
E	GLN54
A	ARG45
E	GLN67
F	TYR9
F	ARG45
F	GLN54
F	GLN67
G	TYR9
G	ARG45
G	GLN54
G	GLN67
H	TYR9
A	GLN54
H	ARG45
H	GLN54
H	GLN67
I	TYR9
I	ARG45
I	GLN54
I	GLN67
J	TYR9
J	ARG45
J	GLN54
A	GLN67
J	GLN67
K	TYR9
K	ARG45
K	GLN54
K	GLN67
L	TYR9
L	ARG45
L	GLN54
L	GLN67
M	TYR9
B	TYR9
M	ARG45
M	GLN54
M	GLN67
N	TYR9
N	ARG45
N	GLN54
N	GLN67
O	TYR9
O	ARG45
O	GLN54
B	ARG45
O	GLN67
P	TYR9
P	ARG45
P	GLN54
P	GLN67
B	GLN54
B	GLN67
C	TYR9

site_id	SWS_FT_FI2
Number of Residues	16
Details	MOD_RES: N-acetylalanine => ECO:0000250\|UniProtKB:P30115

Chain	Residue	Details
A	ALA2
J	ALA2
K	ALA2
L	ALA2
M	ALA2
N	ALA2
O	ALA2
P	ALA2
B	ALA2
C	ALA2
D	ALA2
E	ALA2
F	ALA2
G	ALA2
H	ALA2
I	ALA2

site_id	SWS_FT_FI3
Number of Residues	16
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P30115

Chain	Residue	Details
A	LYS4
J	LYS4
K	LYS4
L	LYS4
M	LYS4
N	LYS4
O	LYS4
P	LYS4
B	LYS4
C	LYS4
D	LYS4
E	LYS4
F	LYS4
G	LYS4
H	LYS4
I	LYS4

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)