2VC4

Ricin A-Chain (Recombinant) E177D Mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017148	biological_process	negative regulation of translation
A	0030598	molecular_function	rRNA N-glycosylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A1268

Chain	Residue
A	TYR80
A	VAL81
A	PHE93
A	GLY121
A	ASN122
A	HOH2168
A	HOH2397
A	HOH2398
A	HOH2399

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A1269

Chain	Residue
A	PHE119
A	GLY120
A	ASN122
A	ARG125
A	HOH2228
A	HOH2400

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A1270

Chain	Residue
A	THR17
A	GLN19
A	HIS65
A	HOH2401
A	HOH2402
A	HOH2403
A	HOH2404

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P84531

Chain	Residue	Details
A	ASP177
A	ARG180
A	TYR80
A	TYR123

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ILE8

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	GLY15
A	GLY50
A	ASN141
A	ASN195

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site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8780513, ECO:0007744|PDB:1OBT

Chain	Residue	Details
A	GLY121
A	TYR80

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1368517

Chain	Residue	Details
A	ASN10

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:1368517

Chain	Residue	Details
A	ASN236

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