2VBQ
Structure of AAC(6')-Iy in complex with bisubstrate analog CoA-S- monomethyl-acetylneamine.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006084 | biological_process | acetyl-CoA metabolic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0047663 | molecular_function | aminoglycoside 6'-N-acetyltransferase activity |
| B | 0006084 | biological_process | acetyl-CoA metabolic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0047663 | molecular_function | aminoglycoside 6'-N-acetyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE BSJ A1000 |
| Chain | Residue |
| A | LEU21 |
| A | GLN89 |
| A | ARG90 |
| A | GLY91 |
| A | VAL92 |
| A | ALA93 |
| A | LYS94 |
| A | ASP115 |
| A | THR116 |
| A | ASN120 |
| A | ILE122 |
| A | TRP22 |
| A | SER123 |
| A | VAL126 |
| A | ALA129 |
| A | LEU130 |
| A | HOH2057 |
| A | HOH2094 |
| A | HOH2095 |
| A | HOH2096 |
| A | HOH2098 |
| A | HOH2099 |
| A | HIS25 |
| A | HOH2100 |
| A | HOH2101 |
| A | HOH2102 |
| A | HOH2104 |
| B | TYR66 |
| B | ASN68 |
| B | ARG110 |
| B | GLU136 |
| B | VAL138 |
| A | GLU79 |
| A | GLY80 |
| A | ILE81 |
| A | PHE82 |
| A | VAL83 |
| A | ARG88 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI A1001 |
| Chain | Residue |
| A | HIS0 |
| A | ASP2 |
| A | HIS42 |
| A | HIS64 |
| site_id | AC3 |
| Number of Residues | 41 |
| Details | BINDING SITE FOR RESIDUE BSJ B1146 |
| Chain | Residue |
| A | TYR66 |
| A | ASN68 |
| A | GLU136 |
| A | VAL138 |
| B | TRP22 |
| B | HIS25 |
| B | GLU79 |
| B | GLY80 |
| B | ILE81 |
| B | PHE82 |
| B | VAL83 |
| B | ARG88 |
| B | GLN89 |
| B | ARG90 |
| B | GLY91 |
| B | VAL92 |
| B | ALA93 |
| B | LYS94 |
| B | ASP115 |
| B | THR116 |
| B | ASN120 |
| B | ILE122 |
| B | SER123 |
| B | VAL126 |
| B | HIS127 |
| B | ALA129 |
| B | LEU130 |
| B | HOH2032 |
| B | HOH2049 |
| B | HOH2097 |
| B | HOH2098 |
| B | HOH2100 |
| B | HOH2103 |
| B | HOH2104 |
| B | HOH2105 |
| B | HOH2106 |
| B | HOH2107 |
| B | HOH2108 |
| B | HOH2109 |
| B | HOH2110 |
| B | HOH2111 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A1002 |
| Chain | Residue |
| A | GLU36 |
| A | HIS42 |
| A | LEU43 |
| A | SER61 |
| A | HOH2108 |
| B | HIS64 |
| B | ASP65 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15123251 |
| Chain | Residue | Details |
| A | TRP22 | |
| B | TRP22 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15123251, ECO:0000269|PubMed:18095712 |
| Chain | Residue | Details |
| A | HIS25 | |
| B | TYR66 | |
| B | GLU79 | |
| B | ILE81 | |
| B | GLN89 | |
| B | ASP115 | |
| B | ASN120 | |
| B | GLU136 | |
| A | TYR66 | |
| A | GLU79 | |
| A | ILE81 | |
| A | GLN89 | |
| A | ASP115 | |
| A | ASN120 | |
| A | GLU136 | |
| B | HIS25 |
