2VAV
Crystal structure of deacetylcephalosporin C acetyltransferase (DAC-Soak)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009092 | biological_process | homoserine metabolic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0017000 | biological_process | antibiotic biosynthetic process |
| A | 0033813 | molecular_function | deacetylcephalosporin-C acetyltransferase activity |
| B | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0009092 | biological_process | homoserine metabolic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0017000 | biological_process | antibiotic biosynthetic process |
| B | 0033813 | molecular_function | deacetylcephalosporin-C acetyltransferase activity |
| C | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009086 | biological_process | methionine biosynthetic process |
| C | 0009092 | biological_process | homoserine metabolic process |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0017000 | biological_process | antibiotic biosynthetic process |
| C | 0033813 | molecular_function | deacetylcephalosporin-C acetyltransferase activity |
| D | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009086 | biological_process | methionine biosynthetic process |
| D | 0009092 | biological_process | homoserine metabolic process |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0017000 | biological_process | antibiotic biosynthetic process |
| D | 0033813 | molecular_function | deacetylcephalosporin-C acetyltransferase activity |
| E | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| E | 0009058 | biological_process | biosynthetic process |
| E | 0009086 | biological_process | methionine biosynthetic process |
| E | 0009092 | biological_process | homoserine metabolic process |
| E | 0016746 | molecular_function | acyltransferase activity |
| E | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| E | 0017000 | biological_process | antibiotic biosynthetic process |
| E | 0033813 | molecular_function | deacetylcephalosporin-C acetyltransferase activity |
| F | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| F | 0009058 | biological_process | biosynthetic process |
| F | 0009086 | biological_process | methionine biosynthetic process |
| F | 0009092 | biological_process | homoserine metabolic process |
| F | 0016746 | molecular_function | acyltransferase activity |
| F | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| F | 0017000 | biological_process | antibiotic biosynthetic process |
| F | 0033813 | molecular_function | deacetylcephalosporin-C acetyltransferase activity |
| G | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| G | 0009058 | biological_process | biosynthetic process |
| G | 0009086 | biological_process | methionine biosynthetic process |
| G | 0009092 | biological_process | homoserine metabolic process |
| G | 0016746 | molecular_function | acyltransferase activity |
| G | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| G | 0017000 | biological_process | antibiotic biosynthetic process |
| G | 0033813 | molecular_function | deacetylcephalosporin-C acetyltransferase activity |
| H | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| H | 0009058 | biological_process | biosynthetic process |
| H | 0009086 | biological_process | methionine biosynthetic process |
| H | 0009092 | biological_process | homoserine metabolic process |
| H | 0016746 | molecular_function | acyltransferase activity |
| H | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| H | 0017000 | biological_process | antibiotic biosynthetic process |
| H | 0033813 | molecular_function | deacetylcephalosporin-C acetyltransferase activity |
| I | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| I | 0009058 | biological_process | biosynthetic process |
| I | 0009086 | biological_process | methionine biosynthetic process |
| I | 0009092 | biological_process | homoserine metabolic process |
| I | 0016746 | molecular_function | acyltransferase activity |
| I | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| I | 0017000 | biological_process | antibiotic biosynthetic process |
| I | 0033813 | molecular_function | deacetylcephalosporin-C acetyltransferase activity |
| J | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| J | 0009058 | biological_process | biosynthetic process |
| J | 0009086 | biological_process | methionine biosynthetic process |
| J | 0009092 | biological_process | homoserine metabolic process |
| J | 0016746 | molecular_function | acyltransferase activity |
| J | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| J | 0017000 | biological_process | antibiotic biosynthetic process |
| J | 0033813 | molecular_function | deacetylcephalosporin-C acetyltransferase activity |
| K | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| K | 0009058 | biological_process | biosynthetic process |
| K | 0009086 | biological_process | methionine biosynthetic process |
| K | 0009092 | biological_process | homoserine metabolic process |
| K | 0016746 | molecular_function | acyltransferase activity |
| K | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| K | 0017000 | biological_process | antibiotic biosynthetic process |
| K | 0033813 | molecular_function | deacetylcephalosporin-C acetyltransferase activity |
| L | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| L | 0009058 | biological_process | biosynthetic process |
| L | 0009086 | biological_process | methionine biosynthetic process |
| L | 0009092 | biological_process | homoserine metabolic process |
| L | 0016746 | molecular_function | acyltransferase activity |
| L | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| L | 0017000 | biological_process | antibiotic biosynthetic process |
| L | 0033813 | molecular_function | deacetylcephalosporin-C acetyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CSC A1383 |
| Chain | Residue |
| A | THR58 |
| A | MET367 |
| A | LEU59 |
| A | THR60 |
| A | OAS149 |
| A | ARG218 |
| A | TYR225 |
| A | LYS226 |
| A | ARG234 |
| A | ASP363 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CSC B1384 |
| Chain | Residue |
| B | THR58 |
| B | LEU59 |
| B | THR60 |
| B | OAS149 |
| B | ARG218 |
| B | TYR225 |
| B | LYS226 |
| B | ARG234 |
| B | GLN281 |
| B | ASP363 |
| B | MET367 |
| B | HOH2006 |
| B | HOH2051 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CSC C1383 |
| Chain | Residue |
| C | THR58 |
| C | LEU59 |
| C | THR60 |
| C | OAS149 |
| C | ARG218 |
| C | TYR225 |
| C | LYS226 |
| C | ARG234 |
| C | TYR277 |
| C | MET367 |
| C | HOH2006 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CSC D1383 |
| Chain | Residue |
| D | THR58 |
| D | LEU59 |
| D | THR60 |
| D | OAS149 |
| D | ARG218 |
| D | TYR225 |
| D | LYS226 |
| D | ARG234 |
| D | TYR277 |
| D | MET367 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CSC E1383 |
| Chain | Residue |
| E | THR58 |
| E | LEU59 |
| E | THR60 |
| E | OAS149 |
| E | ARG218 |
| E | TYR225 |
| E | LYS226 |
| E | ARG234 |
| E | TYR277 |
| E | GLN281 |
| E | ASP363 |
| E | MET367 |
| E | HOH2046 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CSC F1383 |
| Chain | Residue |
| F | THR58 |
| F | LEU59 |
| F | THR60 |
| F | OAS149 |
| F | MET150 |
| F | ARG218 |
| F | TYR225 |
| F | LYS226 |
| F | ARG234 |
| F | TYR277 |
| F | PHE301 |
| F | ASP363 |
| F | PHE365 |
| F | VAL366 |
| F | MET367 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CSC G1383 |
| Chain | Residue |
| G | THR58 |
| G | LEU59 |
| G | THR60 |
| G | SER61 |
| G | OAS149 |
| G | ARG218 |
| G | TYR225 |
| G | LYS226 |
| G | ARG234 |
| G | GLN281 |
| G | ASP363 |
| G | MET367 |
| G | HOH2052 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CSC H1383 |
| Chain | Residue |
| H | THR58 |
| H | LEU59 |
| H | THR60 |
| H | SER61 |
| H | OAS149 |
| H | MET150 |
| H | ARG218 |
| H | TYR225 |
| H | LYS226 |
| H | ARG234 |
| H | HIS362 |
| H | ASP363 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CSC I1383 |
| Chain | Residue |
| I | THR60 |
| I | OAS149 |
| I | ARG218 |
| I | TYR225 |
| I | LYS226 |
| I | ARG234 |
| I | GLN281 |
| I | ASP363 |
| I | THR58 |
| I | LEU59 |
| site_id | BC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CSC J1385 |
| Chain | Residue |
| J | THR58 |
| J | LEU59 |
| J | THR60 |
| J | OAS149 |
| J | ARG218 |
| J | TYR225 |
| J | LYS226 |
| J | ARG234 |
| J | TYR277 |
| J | GLN281 |
| J | ASP363 |
| J | PHE365 |
| J | VAL366 |
| site_id | BC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CSC K1385 |
| Chain | Residue |
| K | THR58 |
| K | LEU59 |
| K | THR60 |
| K | OAS149 |
| K | ARG218 |
| K | TYR225 |
| K | LYS226 |
| K | ARG234 |
| K | TYR277 |
| K | GLN281 |
| K | ASP363 |
| K | VAL366 |
| site_id | BC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE CSC L1383 |
| Chain | Residue |
| L | THR58 |
| L | LEU59 |
| L | THR60 |
| L | OAS149 |
| L | MET150 |
| L | ARG218 |
| L | TYR225 |
| L | LYS226 |
| L | ARG234 |
| L | TYR277 |
| L | GLN281 |
| L | PHE301 |
| L | HIS362 |
| L | ASP363 |
| L | VAL366 |
| L | MET367 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A1384 |
| Chain | Residue |
| A | GLU157 |
| A | PHE161 |
| B | THR25 |
| B | ILE31 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B1385 |
| Chain | Residue |
| A | THR25 |
| A | ILE31 |
| B | GLU157 |
| B | PHE161 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT E1384 |
| Chain | Residue |
| E | GLU157 |
| E | PHE161 |
| I | THR25 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT I1384 |
| Chain | Residue |
| E | THR25 |
| E | ILE31 |
| I | GLU157 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT H1384 |
| Chain | Residue |
| H | ARG128 |
| H | GLU157 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT G1384 |
| Chain | Residue |
| G | ARG128 |
| G | GLU157 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT D1384 |
| Chain | Residue |
| D | ARG128 |
| D | GLU157 |
| D | PHE161 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT F1384 |
| Chain | Residue |
| F | ARG128 |
| F | GLU157 |
| F | PHE161 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT C1384 |
| Chain | Residue |
| A | VAL47 |
| C | ARG128 |
| C | GLU157 |
| C | PHE161 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT L1384 |
| Chain | Residue |
| L | ARG128 |
| L | GLU157 |
| L | PHE161 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B1386 |
| Chain | Residue |
| A | SER22 |
| B | ARG131 |
| B | ASP135 |
| B | TYR165 |
| site_id | CC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A1385 |
| Chain | Residue |
| A | ASP135 |
| A | ARG140 |
| B | SER22 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT E1385 |
| Chain | Residue |
| E | ARG131 |
| E | ASP135 |
| E | ARG140 |
| I | SER22 |
| site_id | CC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT I1385 |
| Chain | Residue |
| E | SER22 |
| I | TYR165 |
| site_id | CC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT I1386 |
| Chain | Residue |
| I | ARG331 |
| I | PHE338 |
| K | PHE338 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255 |
| Chain | Residue | Details |
| A | OAS149 | |
| E | HIS362 | |
| F | OAS149 | |
| F | HIS362 | |
| G | OAS149 | |
| G | HIS362 | |
| H | OAS149 | |
| H | HIS362 | |
| I | OAS149 | |
| I | HIS362 | |
| J | OAS149 | |
| A | HIS362 | |
| J | HIS362 | |
| K | OAS149 | |
| K | HIS362 | |
| L | OAS149 | |
| L | HIS362 | |
| B | OAS149 | |
| B | HIS362 | |
| C | OAS149 | |
| C | HIS362 | |
| D | OAS149 | |
| D | HIS362 | |
| E | OAS149 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1azw |
| Chain | Residue | Details |
| A | HIS362 | |
| A | ASP333 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1azw |
| Chain | Residue | Details |
| J | HIS362 | |
| J | ASP333 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1azw |
| Chain | Residue | Details |
| K | HIS362 | |
| K | ASP333 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1azw |
| Chain | Residue | Details |
| L | HIS362 | |
| L | ASP333 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1azw |
| Chain | Residue | Details |
| B | HIS362 | |
| B | ASP333 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1azw |
| Chain | Residue | Details |
| C | HIS362 | |
| C | ASP333 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1azw |
| Chain | Residue | Details |
| D | HIS362 | |
| D | ASP333 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1azw |
| Chain | Residue | Details |
| E | HIS362 | |
| E | ASP333 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1azw |
| Chain | Residue | Details |
| F | HIS362 | |
| F | ASP333 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1azw |
| Chain | Residue | Details |
| G | HIS362 | |
| G | ASP333 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1azw |
| Chain | Residue | Details |
| H | HIS362 | |
| H | ASP333 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1azw |
| Chain | Residue | Details |
| I | HIS362 | |
| I | ASP333 |
